Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts

Detalhes bibliográficos
Autor(a) principal: Neto, Conrado M. S.
Data de Publicação: 2021
Outros Autores: Lima, Felipe C., Morais, Renata P., de Andrade, Lucas R. M., de Lima, Renata, Chaud, Marco V., Pereira, Matheus M., de Albuquerque Júnior, Ricardo L. C., Cardoso, Juliana C., Zielinska, Aleksandra, Souto, Eliana B., Lima, Álvaro S., Severino, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/73775
Resumo: Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.
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spelling Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblastsMulti-walled carbon nanotubesRutinFlavonoidsDrug deliveryCytotoxicityScience & TechnologyMulti-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.The authors acknowledge Classius Ferreira da Silva, from the Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, for the scanning electron microscopy analyses.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoNeto, Conrado M. S.Lima, Felipe C.Morais, Renata P.de Andrade, Lucas R. M.de Lima, RenataChaud, Marco V.Pereira, Matheus M.de Albuquerque Júnior, Ricardo L. C.Cardoso, Juliana C.Zielinska, AleksandraSouto, Eliana B.Lima, Álvaro S.Severino, Patrícia2021-07-222021-07-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73775engNeto, Conrado M. S.; Lima, Felipe C.; Morais, Renata P.; de Andrade, Lucas R. M.; de Lima, Renata; Chaud, Marco V.; Pereira, Matheus M.; de Albuquerque Júnior, Ricardo L. C.; Cardoso, Juliana C.; Zielinska, Aleksandra; Souto, Eliana; Lima, Álvaro S.; Severino, Patrícia, Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts. Toxics, 9(8), 173, 20212305-630410.3390/toxics9080173https://www.mdpi.com/2305-6304/9/8/173info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:33Zoai:repositorium.sdum.uminho.pt:1822/73775Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:41.850186Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
title Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
spellingShingle Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
Neto, Conrado M. S.
Multi-walled carbon nanotubes
Rutin
Flavonoids
Drug delivery
Cytotoxicity
Science & Technology
title_short Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
title_full Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
title_fullStr Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
title_full_unstemmed Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
title_sort Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
author Neto, Conrado M. S.
author_facet Neto, Conrado M. S.
Lima, Felipe C.
Morais, Renata P.
de Andrade, Lucas R. M.
de Lima, Renata
Chaud, Marco V.
Pereira, Matheus M.
de Albuquerque Júnior, Ricardo L. C.
Cardoso, Juliana C.
Zielinska, Aleksandra
Souto, Eliana B.
Lima, Álvaro S.
Severino, Patrícia
author_role author
author2 Lima, Felipe C.
Morais, Renata P.
de Andrade, Lucas R. M.
de Lima, Renata
Chaud, Marco V.
Pereira, Matheus M.
de Albuquerque Júnior, Ricardo L. C.
Cardoso, Juliana C.
Zielinska, Aleksandra
Souto, Eliana B.
Lima, Álvaro S.
Severino, Patrícia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Neto, Conrado M. S.
Lima, Felipe C.
Morais, Renata P.
de Andrade, Lucas R. M.
de Lima, Renata
Chaud, Marco V.
Pereira, Matheus M.
de Albuquerque Júnior, Ricardo L. C.
Cardoso, Juliana C.
Zielinska, Aleksandra
Souto, Eliana B.
Lima, Álvaro S.
Severino, Patrícia
dc.subject.por.fl_str_mv Multi-walled carbon nanotubes
Rutin
Flavonoids
Drug delivery
Cytotoxicity
Science & Technology
topic Multi-walled carbon nanotubes
Rutin
Flavonoids
Drug delivery
Cytotoxicity
Science & Technology
description Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-22
2021-07-22T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/73775
url http://hdl.handle.net/1822/73775
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neto, Conrado M. S.; Lima, Felipe C.; Morais, Renata P.; de Andrade, Lucas R. M.; de Lima, Renata; Chaud, Marco V.; Pereira, Matheus M.; de Albuquerque Júnior, Ricardo L. C.; Cardoso, Juliana C.; Zielinska, Aleksandra; Souto, Eliana; Lima, Álvaro S.; Severino, Patrícia, Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts. Toxics, 9(8), 173, 2021
2305-6304
10.3390/toxics9080173
https://www.mdpi.com/2305-6304/9/8/173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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