Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73775 |
Resumo: | Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblastsMulti-walled carbon nanotubesRutinFlavonoidsDrug deliveryCytotoxicityScience & TechnologyMulti-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.The authors acknowledge Classius Ferreira da Silva, from the Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, for the scanning electron microscopy analyses.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoNeto, Conrado M. S.Lima, Felipe C.Morais, Renata P.de Andrade, Lucas R. M.de Lima, RenataChaud, Marco V.Pereira, Matheus M.de Albuquerque Júnior, Ricardo L. C.Cardoso, Juliana C.Zielinska, AleksandraSouto, Eliana B.Lima, Álvaro S.Severino, Patrícia2021-07-222021-07-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73775engNeto, Conrado M. S.; Lima, Felipe C.; Morais, Renata P.; de Andrade, Lucas R. M.; de Lima, Renata; Chaud, Marco V.; Pereira, Matheus M.; de Albuquerque Júnior, Ricardo L. C.; Cardoso, Juliana C.; Zielinska, Aleksandra; Souto, Eliana; Lima, Álvaro S.; Severino, Patrícia, Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts. Toxics, 9(8), 173, 20212305-630410.3390/toxics9080173https://www.mdpi.com/2305-6304/9/8/173info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:33Zoai:repositorium.sdum.uminho.pt:1822/73775Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:41.850186Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
title |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
spellingShingle |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts Neto, Conrado M. S. Multi-walled carbon nanotubes Rutin Flavonoids Drug delivery Cytotoxicity Science & Technology |
title_short |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
title_full |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
title_fullStr |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
title_full_unstemmed |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
title_sort |
Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
author |
Neto, Conrado M. S. |
author_facet |
Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielinska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia |
author_role |
author |
author2 |
Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielinska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielinska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia |
dc.subject.por.fl_str_mv |
Multi-walled carbon nanotubes Rutin Flavonoids Drug delivery Cytotoxicity Science & Technology |
topic |
Multi-walled carbon nanotubes Rutin Flavonoids Drug delivery Cytotoxicity Science & Technology |
description |
Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a doseeffect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-22 2021-07-22T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73775 |
url |
http://hdl.handle.net/1822/73775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neto, Conrado M. S.; Lima, Felipe C.; Morais, Renata P.; de Andrade, Lucas R. M.; de Lima, Renata; Chaud, Marco V.; Pereira, Matheus M.; de Albuquerque Júnior, Ricardo L. C.; Cardoso, Juliana C.; Zielinska, Aleksandra; Souto, Eliana; Lima, Álvaro S.; Severino, Patrícia, Rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts. Toxics, 9(8), 173, 2021 2305-6304 10.3390/toxics9080173 https://www.mdpi.com/2305-6304/9/8/173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132469794963456 |