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Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions

Detalhes bibliográficos
Autor(a) principal: Catarata, Maria Joana
Data de Publicação: 2020
Outros Autores: Ribeiro, Ricardo, Oliveira, Maria José, Cordeiro, Carlos Robalo, Medeiros, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105847
https://doi.org/10.3390/cancers12061457
Resumo: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
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spelling Renin-Angiotensin System in Lung Tumor and Microenvironment Interactionslung cancerrenin-angiotensinhypoxiatumor microenvironmentThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.MDPI2020-06-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105847http://hdl.handle.net/10316/105847https://doi.org/10.3390/cancers12061457eng2072-6694Catarata, Maria JoanaRibeiro, RicardoOliveira, Maria JoséCordeiro, Carlos RobaloMedeiros, Ruiinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T21:34:22Zoai:estudogeral.uc.pt:10316/105847Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:20.730587Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
title Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
spellingShingle Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
Catarata, Maria Joana
lung cancer
renin-angiotensin
hypoxia
tumor microenvironment
title_short Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
title_full Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
title_fullStr Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
title_full_unstemmed Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
title_sort Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions
author Catarata, Maria Joana
author_facet Catarata, Maria Joana
Ribeiro, Ricardo
Oliveira, Maria José
Cordeiro, Carlos Robalo
Medeiros, Rui
author_role author
author2 Ribeiro, Ricardo
Oliveira, Maria José
Cordeiro, Carlos Robalo
Medeiros, Rui
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Catarata, Maria Joana
Ribeiro, Ricardo
Oliveira, Maria José
Cordeiro, Carlos Robalo
Medeiros, Rui
dc.subject.por.fl_str_mv lung cancer
renin-angiotensin
hypoxia
tumor microenvironment
topic lung cancer
renin-angiotensin
hypoxia
tumor microenvironment
description The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105847
http://hdl.handle.net/10316/105847
https://doi.org/10.3390/cancers12061457
url http://hdl.handle.net/10316/105847
https://doi.org/10.3390/cancers12061457
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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