Impact of polymicrobial biofilms in catheter-associated urinary tract infections
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/46274 |
Resumo: | Recent reports have demonstrated that most biofilms involved in catheter-associated urinary tract infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome. This lack of knowledge affects CAUTIs management as uncommon bacteria action can, for instance, influence the rate at which pathogens adhere and grow, as well as affect the overall biofilm resistance to antibiotics. Another relevant aspect is the understanding of factors that drive a single pathogenic bacterium to become prevalent in a polymicrobial community and subsequently cause infection. In this review, a general overview about the IMDs-associated biofilm infections is provided, with an emphasis on the pathophysiology and the microbiome composition of CAUTIs. Based on the available literature, it is clear that more research about the microbiome interaction, mechanisms of biofilm formation and of antimicrobial tolerance of the polymicrobial consortium are required to better understand and treat these infections. |
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Impact of polymicrobial biofilms in catheter-associated urinary tract infectionsCatheter-associated urinary tract infectionsPathogenic bacteriaUncommon bacteriaMicrobiomeMicrobial ecologyScience & TechnologyRecent reports have demonstrated that most biofilms involved in catheter-associated urinary tract infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome. This lack of knowledge affects CAUTIs management as uncommon bacteria action can, for instance, influence the rate at which pathogens adhere and grow, as well as affect the overall biofilm resistance to antibiotics. Another relevant aspect is the understanding of factors that drive a single pathogenic bacterium to become prevalent in a polymicrobial community and subsequently cause infection. In this review, a general overview about the IMDs-associated biofilm infections is provided, with an emphasis on the pathophysiology and the microbiome composition of CAUTIs. Based on the available literature, it is clear that more research about the microbiome interaction, mechanisms of biofilm formation and of antimicrobial tolerance of the polymicrobial consortium are required to better understand and treat these infections.This work was financially supported by: Project POCI-010145-FEDER-006939 – Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT – Fundacao para a Ci^encia e a Tecnologia; Project “DNAmimics” [PIC/IC/82815/2007]; PhD fellowships [SFRH/BD/82663/2011].info:eu-repo/semantics/publishedVersionTaylor and FrancisUniversidade do MinhoAzevedo, Andreia S.Almeida, CarinaMelo, Luís F.Azevedo, Nuno F.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/46274engAzevedo, Andreia S.; Almeida, Carina; Melo, Luís F.; Azevedo, Nuno F., Impact of polymicrobial biofilms in catheter-associated urinary tract infections. Critical Reviews in Microbiology, 43(4), 423-439, 20171040-841X1549-782810.1080/1040841X.2016.124065628033847http://informahealthcare.com/journal/mbyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:03Zoai:repositorium.sdum.uminho.pt:1822/46274Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:20:23.185229Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
title |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
spellingShingle |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections Azevedo, Andreia S. Catheter-associated urinary tract infections Pathogenic bacteria Uncommon bacteria Microbiome Microbial ecology Science & Technology |
title_short |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
title_full |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
title_fullStr |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
title_full_unstemmed |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
title_sort |
Impact of polymicrobial biofilms in catheter-associated urinary tract infections |
author |
Azevedo, Andreia S. |
author_facet |
Azevedo, Andreia S. Almeida, Carina Melo, Luís F. Azevedo, Nuno F. |
author_role |
author |
author2 |
Almeida, Carina Melo, Luís F. Azevedo, Nuno F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Azevedo, Andreia S. Almeida, Carina Melo, Luís F. Azevedo, Nuno F. |
dc.subject.por.fl_str_mv |
Catheter-associated urinary tract infections Pathogenic bacteria Uncommon bacteria Microbiome Microbial ecology Science & Technology |
topic |
Catheter-associated urinary tract infections Pathogenic bacteria Uncommon bacteria Microbiome Microbial ecology Science & Technology |
description |
Recent reports have demonstrated that most biofilms involved in catheter-associated urinary tract infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome. This lack of knowledge affects CAUTIs management as uncommon bacteria action can, for instance, influence the rate at which pathogens adhere and grow, as well as affect the overall biofilm resistance to antibiotics. Another relevant aspect is the understanding of factors that drive a single pathogenic bacterium to become prevalent in a polymicrobial community and subsequently cause infection. In this review, a general overview about the IMDs-associated biofilm infections is provided, with an emphasis on the pathophysiology and the microbiome composition of CAUTIs. Based on the available literature, it is clear that more research about the microbiome interaction, mechanisms of biofilm formation and of antimicrobial tolerance of the polymicrobial consortium are required to better understand and treat these infections. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/46274 |
url |
http://hdl.handle.net/1822/46274 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Azevedo, Andreia S.; Almeida, Carina; Melo, Luís F.; Azevedo, Nuno F., Impact of polymicrobial biofilms in catheter-associated urinary tract infections. Critical Reviews in Microbiology, 43(4), 423-439, 2017 1040-841X 1549-7828 10.1080/1040841X.2016.1240656 28033847 http://informahealthcare.com/journal/mby |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor and Francis |
publisher.none.fl_str_mv |
Taylor and Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132666095730688 |