Expression of mTOR in normal and pathological conditions

Detalhes bibliográficos
Autor(a) principal: Marques-Ramos, Ana
Data de Publicação: 2023
Outros Autores: Cervantes, Renata
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/16353
Resumo: The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.
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spelling Expression of mTOR in normal and pathological conditionsmTOR biomarkemTOR expressionmTOR expression cancermTOR expression diseasemTOR mRNA stabilitymTOR transcriptional regulationmTOR translation regulationIPL/2021/GATumor_ESTeSLFCT_UIDB/05608/2020FCT_UIDP/05608/2020The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991, integrates a complex pathway with a key role in maintaining cellular homeostasis. By comprising two functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2, it is a central cellular hub that integrates intra- and extracellular signals of energy, nutrient, and hormone availability, modulating the molecular responses to acquire a homeostatic state through the regulation of anabolic and catabolic processes. Accordingly, dysregulation of the mTOR pathway has been implicated in a variety of human diseases. While major advances have been made regarding the regulators and effectors of the mTOR signaling pathway, insights into the regulation of mTOR gene expression are beginning to emerge. Here, we present the currently available data regarding the mTOR expression regulation at the level of transcription, translation, and mRNA stability and systematize the current knowledge about the fluctuations of mTOR expression observed in several diseases, both cancerous and non-cancerous. In addition, we discuss whether mTOR expression changes can be used as a biomarker for diagnosis, disease progression, prognosis, and/or response to therapeutics. We believe that our study will contribute to the implementation of new disease biomarkers based on mTOR as it gives an exhaustive perspective on the regulation of mTOR gene expression in both normal and pathological conditions.Springer NatureRCIPLMarques-Ramos, AnaCervantes, Renata2023-08-01T11:09:33Z2023-072023-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/16353engMarques-Ramos A, Cervantes R. Expression of mTOR in normal and pathological conditions. Mol Cancer. 2023;22(1):112.10.1186/s12943-023-01820-zinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:14:57Zoai:repositorio.ipl.pt:10400.21/16353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:23:54.434655Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Expression of mTOR in normal and pathological conditions
title Expression of mTOR in normal and pathological conditions
spellingShingle Expression of mTOR in normal and pathological conditions
Marques-Ramos, Ana
mTOR biomarke
mTOR expression
mTOR expression cancer
mTOR expression disease
mTOR mRNA stability
mTOR transcriptional regulation
mTOR translation regulation
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Expression of mTOR in normal and pathological conditions
title_full Expression of mTOR in normal and pathological conditions
title_fullStr Expression of mTOR in normal and pathological conditions
title_full_unstemmed Expression of mTOR in normal and pathological conditions
title_sort Expression of mTOR in normal and pathological conditions
author Marques-Ramos, Ana
author_facet Marques-Ramos, Ana
Cervantes, Renata
author_role author
author2 Cervantes, Renata
author2_role author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Marques-Ramos, Ana
Cervantes, Renata
dc.subject.por.fl_str_mv mTOR biomarke
mTOR expression
mTOR expression cancer
mTOR expression disease
mTOR mRNA stability
mTOR transcriptional regulation
mTOR translation regulation
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic mTOR biomarke
mTOR expression
mTOR expression cancer
mTOR expression disease
mTOR mRNA stability
mTOR transcriptional regulation
mTOR translation regulation
IPL/2021/GATumor_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description The H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020. This work was part of the IPL/2021/GATumor_ESTeSL project.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-01T11:09:33Z
2023-07
2023-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/16353
url http://hdl.handle.net/10400.21/16353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marques-Ramos A, Cervantes R. Expression of mTOR in normal and pathological conditions. Mol Cancer. 2023;22(1):112.
10.1186/s12943-023-01820-z
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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