EDCs mixtures: a stealthy hazard for human health ?

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Edna
Data de Publicação: 2017
Outros Autores: Ladeira, Carina, Viegas, Susana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/14144
Resumo: Review
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spelling EDCs mixtures: a stealthy hazard for human health ?endocrine disrupting chemicalsmixturesbiomonitoringwindows of exposurerisk assessmentReviewEndocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally (e.g., phytoestrogens), while others are industrial substances and plasticizers commonly utilized worldwide to which human exposure, particularly at low-doses, is omnipresent, persistent and occurs in complex mixtures. EDCs can interfere with/or mimic estrogenic hormones and, consequently, can simultaneously trigger diverse signaling pathways which result in diverse and divergent biological responses. Additionally, EDCs can also bioaccumulate in lipid compartments of the organism forming a mixed “body burden” of contaminants. Although the independent action of chemicals has been considered the main principle in EDCs mixture toxicity, recent studies have demonstrated that numerous effects cannot be predicted when analyzing single compounds independently. Co-exposure to these agents, particularly in critical windows of exposure, may induce hazardous health effects potentially associated with a complex “body burden” of different origins. Here, we performed an exhaustive review of the available literature regarding EDCs mixtures exposure, toxicity mechanisms and effects, particularly at the most vulnerable human life stages. Although the assessment of potential risks to human health due to exposure to EDCs mixtures is a major topic for consumer safety, information regarding effective mixtures effects is still scarceMDPIRepositório da Universidade de LisboaRibeiro, EdnaLadeira, CarinaViegas, Susana2017-10-04T15:19:08Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/14144engToxics 2017, 5, 510.3390/toxics5010005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:44:13Zoai:www.repository.utl.pt:10400.5/14144Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:00:01.729392Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv EDCs mixtures: a stealthy hazard for human health ?
title EDCs mixtures: a stealthy hazard for human health ?
spellingShingle EDCs mixtures: a stealthy hazard for human health ?
Ribeiro, Edna
endocrine disrupting chemicals
mixtures
biomonitoring
windows of exposure
risk assessment
title_short EDCs mixtures: a stealthy hazard for human health ?
title_full EDCs mixtures: a stealthy hazard for human health ?
title_fullStr EDCs mixtures: a stealthy hazard for human health ?
title_full_unstemmed EDCs mixtures: a stealthy hazard for human health ?
title_sort EDCs mixtures: a stealthy hazard for human health ?
author Ribeiro, Edna
author_facet Ribeiro, Edna
Ladeira, Carina
Viegas, Susana
author_role author
author2 Ladeira, Carina
Viegas, Susana
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Edna
Ladeira, Carina
Viegas, Susana
dc.subject.por.fl_str_mv endocrine disrupting chemicals
mixtures
biomonitoring
windows of exposure
risk assessment
topic endocrine disrupting chemicals
mixtures
biomonitoring
windows of exposure
risk assessment
description Review
publishDate 2017
dc.date.none.fl_str_mv 2017-10-04T15:19:08Z
2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/14144
url http://hdl.handle.net/10400.5/14144
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxics 2017, 5, 5
10.3390/toxics5010005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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