Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4622 |
Resumo: | Background: Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. Objective: This systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes. Methods: A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. Results: A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased. Conclusion: The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow-up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes. |
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Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐AnalysisHSAC GASBiasAdultHumansChildBiological Products / therapeutic useColitis, Ulcerative / diagnosisColitis, Ulcerative / surgeryColitis, Ulcerative / therapy*Confidence IntervalsDisease ProgressionFollow-Up StudiesHospitalizationImmunosuppressive Agents / therapeutic useObservational Studies as Topic* / methodsSteroids / therapeutic useTime FactorsTreatment OutcomeBackground: Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. Objective: This systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes. Methods: A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. Results: A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased. Conclusion: The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow-up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMagro, FAlves, CSantiago, MMinistro, PLago, PCorreia, LGonçalves, RCarvalho, DPortela, FDias, CDignass, ADanese, SPeyrin‐Biroulet, LEstevinho, MMMoreira, P2023-08-02T14:11:52Z2021-022021-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4622engUnited European Gastroenterol J . 2022 Feb;10(1):54-72.10.1002/ueg2.12183info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-13T06:03:15Zoai:repositorio.chlc.min-saude.pt:10400.17/4622Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:26:56.969359Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
title |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
spellingShingle |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis Magro, F HSAC GAS Bias Adult Humans Child Biological Products / therapeutic use Colitis, Ulcerative / diagnosis Colitis, Ulcerative / surgery Colitis, Ulcerative / therapy* Confidence Intervals Disease Progression Follow-Up Studies Hospitalization Immunosuppressive Agents / therapeutic use Observational Studies as Topic* / methods Steroids / therapeutic use Time Factors Treatment Outcome |
title_short |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
title_full |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
title_fullStr |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
title_full_unstemmed |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
title_sort |
Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis |
author |
Magro, F |
author_facet |
Magro, F Alves, C Santiago, M Ministro, P Lago, P Correia, L Gonçalves, R Carvalho, D Portela, F Dias, C Dignass, A Danese, S Peyrin‐Biroulet, L Estevinho, MM Moreira, P |
author_role |
author |
author2 |
Alves, C Santiago, M Ministro, P Lago, P Correia, L Gonçalves, R Carvalho, D Portela, F Dias, C Dignass, A Danese, S Peyrin‐Biroulet, L Estevinho, MM Moreira, P |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Magro, F Alves, C Santiago, M Ministro, P Lago, P Correia, L Gonçalves, R Carvalho, D Portela, F Dias, C Dignass, A Danese, S Peyrin‐Biroulet, L Estevinho, MM Moreira, P |
dc.subject.por.fl_str_mv |
HSAC GAS Bias Adult Humans Child Biological Products / therapeutic use Colitis, Ulcerative / diagnosis Colitis, Ulcerative / surgery Colitis, Ulcerative / therapy* Confidence Intervals Disease Progression Follow-Up Studies Hospitalization Immunosuppressive Agents / therapeutic use Observational Studies as Topic* / methods Steroids / therapeutic use Time Factors Treatment Outcome |
topic |
HSAC GAS Bias Adult Humans Child Biological Products / therapeutic use Colitis, Ulcerative / diagnosis Colitis, Ulcerative / surgery Colitis, Ulcerative / therapy* Confidence Intervals Disease Progression Follow-Up Studies Hospitalization Immunosuppressive Agents / therapeutic use Observational Studies as Topic* / methods Steroids / therapeutic use Time Factors Treatment Outcome |
description |
Background: Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. Objective: This systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes. Methods: A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. Results: A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased. Conclusion: The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow-up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02 2021-02-01T00:00:00Z 2023-08-02T14:11:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4622 |
url |
http://hdl.handle.net/10400.17/4622 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
United European Gastroenterol J . 2022 Feb;10(1):54-72. 10.1002/ueg2.12183 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133538605334528 |