Chiral drug analysis in forensic chemistry: An overview

Detalhes bibliográficos
Autor(a) principal: Ribeiro C.
Data de Publicação: 2018
Outros Autores: Santos C., Gonçalves V., Ramos A., Afonso C., Tiritan M.E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/120514
Resumo: Many substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field. Most frequently analytical methods used to quantify the enantiomers are liquid and gas chromatography using both indirect, with enantiomerically pure derivatizing reagents, and direct methods recurring to chiral stationary phases. © 2018 by the authors.
id RCAP_d5bb8c7a3ef3f630965a0b1ef9fe0780
oai_identifier_str oai:repositorio-aberto.up.pt:10216/120514
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str
spelling Chiral drug analysis in forensic chemistry: An overviewdrugdevicesforensic sciencegas chromatographyliquid chromatographyproceduresChromatography, GasChromatography, LiquidForensic SciencesPharmaceutical PreparationsMany substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field. Most frequently analytical methods used to quantify the enantiomers are liquid and gas chromatography using both indirect, with enantiomerically pure derivatizing reagents, and direct methods recurring to chiral stationary phases. © 2018 by the authors.MDPI20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/120514eng1420304910.3390/molecules23020262Ribeiro C.Santos C.Gonçalves V.Ramos A.Afonso C.Tiritan M.E.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-26T14:06:41ZPortal AgregadorONG
dc.title.none.fl_str_mv Chiral drug analysis in forensic chemistry: An overview
title Chiral drug analysis in forensic chemistry: An overview
spellingShingle Chiral drug analysis in forensic chemistry: An overview
Ribeiro C.
drug
devices
forensic science
gas chromatography
liquid chromatography
procedures
Chromatography, Gas
Chromatography, Liquid
Forensic Sciences
Pharmaceutical Preparations
title_short Chiral drug analysis in forensic chemistry: An overview
title_full Chiral drug analysis in forensic chemistry: An overview
title_fullStr Chiral drug analysis in forensic chemistry: An overview
title_full_unstemmed Chiral drug analysis in forensic chemistry: An overview
title_sort Chiral drug analysis in forensic chemistry: An overview
author Ribeiro C.
author_facet Ribeiro C.
Santos C.
Gonçalves V.
Ramos A.
Afonso C.
Tiritan M.E.
author_role author
author2 Santos C.
Gonçalves V.
Ramos A.
Afonso C.
Tiritan M.E.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro C.
Santos C.
Gonçalves V.
Ramos A.
Afonso C.
Tiritan M.E.
dc.subject.por.fl_str_mv drug
devices
forensic science
gas chromatography
liquid chromatography
procedures
Chromatography, Gas
Chromatography, Liquid
Forensic Sciences
Pharmaceutical Preparations
topic drug
devices
forensic science
gas chromatography
liquid chromatography
procedures
Chromatography, Gas
Chromatography, Liquid
Forensic Sciences
Pharmaceutical Preparations
description Many substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field. Most frequently analytical methods used to quantify the enantiomers are liquid and gas chromatography using both indirect, with enantiomerically pure derivatizing reagents, and direct methods recurring to chiral stationary phases. © 2018 by the authors.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/120514
url https://hdl.handle.net/10216/120514
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 14203049
10.3390/molecules23020262
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1777304158176542720

Registros relacionados