Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach

Detalhes bibliográficos
Autor(a) principal: Viegas, Susana
Data de Publicação: 2018
Outros Autores: Assunção, Ricardo, Nunes, Carla, Osteresch, Bernd, Twarużek, Magdalena, Kosicki, Robert, Grajewski, Jan, Martins, Carla, Alvito, Paula, Almeida, Ana, Viegas, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3390/toxins10090342
Resumo: Mycotoxins are toxic mold metabolites that can persist in environment long after the fungi species responsible for their production disappear. Critical workplace for mycotoxins presence has already been studied and nowadays it is possible to recognize that exposure to mycotoxins through inhalation occurs due to their presence in dust. This study aimed to assess occupational co-exposure to multiple mycotoxins in a fresh bread dough company, an occupational setting not studied until now. Occupational exposure assessment to mycotoxins was done using a LC-MS/MS urinary multi-biomarker approach. Twenty-one workers and nineteen individuals that were used as controls participated in the study. Workers/controls (spot-urine) and environment (settled dust) samples were collected and analyzed. Concerning workers group, DON-GlcA, and OTA were the most prevalent biomarkers (>LOD), 66% and 90.5%, respectively. In the control group, OTA was also one of the most detected (68%) followed by CIT (58%) and DON-GlcA (58%). DON was the mycotoxin measured in high amounts in the settled dust sample (58.2 ng/g). Both workers and controls are exposed to several mycotoxins simultaneously. The workers group, due to their high contact with flour dust, revealed a higher exposure to DON. Considering these results, risk management measures must be applied including specific and adequate health surveillance programs in order to avoid exposure and consequently the associated health consequences.
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spelling Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approachBiomonitoringFungi metabolitesOccupational exposureToxicologyHealth, Toxicology and MutagenesisMycotoxins are toxic mold metabolites that can persist in environment long after the fungi species responsible for their production disappear. Critical workplace for mycotoxins presence has already been studied and nowadays it is possible to recognize that exposure to mycotoxins through inhalation occurs due to their presence in dust. This study aimed to assess occupational co-exposure to multiple mycotoxins in a fresh bread dough company, an occupational setting not studied until now. Occupational exposure assessment to mycotoxins was done using a LC-MS/MS urinary multi-biomarker approach. Twenty-one workers and nineteen individuals that were used as controls participated in the study. Workers/controls (spot-urine) and environment (settled dust) samples were collected and analyzed. Concerning workers group, DON-GlcA, and OTA were the most prevalent biomarkers (>LOD), 66% and 90.5%, respectively. In the control group, OTA was also one of the most detected (68%) followed by CIT (58%) and DON-GlcA (58%). DON was the mycotoxin measured in high amounts in the settled dust sample (58.2 ng/g). Both workers and controls are exposed to several mycotoxins simultaneously. The workers group, due to their high contact with flour dust, revealed a higher exposure to DON. Considering these results, risk management measures must be applied including specific and adequate health surveillance programs in order to avoid exposure and consequently the associated health consequences.Centro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNViegas, SusanaAssunção, RicardoNunes, CarlaOsteresch, BerndTwarużek, MagdalenaKosicki, RobertGrajewski, JanMartins, CarlaAlvito, PaulaAlmeida, AnaViegas, Carla2018-09-12T22:11:07Z2018-09-012018-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.3390/toxins10090342eng2072-6651PURE: 5818956http://www.scopus.com/inward/record.url?scp=85052529986&partnerID=8YFLogxKhttps://doi.org/10.3390/toxins10090342info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:24:25Zoai:run.unl.pt:10362/46380Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:31:58.320483Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
title Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
spellingShingle Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
Viegas, Susana
Biomonitoring
Fungi metabolites
Occupational exposure
Toxicology
Health, Toxicology and Mutagenesis
title_short Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
title_full Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
title_fullStr Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
title_full_unstemmed Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
title_sort Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach
author Viegas, Susana
author_facet Viegas, Susana
Assunção, Ricardo
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Martins, Carla
Alvito, Paula
Almeida, Ana
Viegas, Carla
author_role author
author2 Assunção, Ricardo
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Martins, Carla
Alvito, Paula
Almeida, Ana
Viegas, Carla
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Viegas, Susana
Assunção, Ricardo
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Martins, Carla
Alvito, Paula
Almeida, Ana
Viegas, Carla
dc.subject.por.fl_str_mv Biomonitoring
Fungi metabolites
Occupational exposure
Toxicology
Health, Toxicology and Mutagenesis
topic Biomonitoring
Fungi metabolites
Occupational exposure
Toxicology
Health, Toxicology and Mutagenesis
description Mycotoxins are toxic mold metabolites that can persist in environment long after the fungi species responsible for their production disappear. Critical workplace for mycotoxins presence has already been studied and nowadays it is possible to recognize that exposure to mycotoxins through inhalation occurs due to their presence in dust. This study aimed to assess occupational co-exposure to multiple mycotoxins in a fresh bread dough company, an occupational setting not studied until now. Occupational exposure assessment to mycotoxins was done using a LC-MS/MS urinary multi-biomarker approach. Twenty-one workers and nineteen individuals that were used as controls participated in the study. Workers/controls (spot-urine) and environment (settled dust) samples were collected and analyzed. Concerning workers group, DON-GlcA, and OTA were the most prevalent biomarkers (>LOD), 66% and 90.5%, respectively. In the control group, OTA was also one of the most detected (68%) followed by CIT (58%) and DON-GlcA (58%). DON was the mycotoxin measured in high amounts in the settled dust sample (58.2 ng/g). Both workers and controls are exposed to several mycotoxins simultaneously. The workers group, due to their high contact with flour dust, revealed a higher exposure to DON. Considering these results, risk management measures must be applied including specific and adequate health surveillance programs in order to avoid exposure and consequently the associated health consequences.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-12T22:11:07Z
2018-09-01
2018-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.3390/toxins10090342
url https://doi.org/10.3390/toxins10090342
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6651
PURE: 5818956
http://www.scopus.com/inward/record.url?scp=85052529986&partnerID=8YFLogxK
https://doi.org/10.3390/toxins10090342
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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