Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/20206 |
Resumo: | The fields of tissue engineering and regenerative medicine aim at promoting the regeneration of tissues or replacing failing or malfunctioning organs, by means of combining a scaffold/support material, adequate cells and bioactive molecules. Different materials have been proposed to be used as both three-dimensional porous scaffolds and hydrogel matrices for distinct tissue engineering strategies. Among them, polymers of natural origin are one of the most attractive options, mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good biological performance. In this review, the most studied and promising and recently proposed naturally derived polymers that have been suggested for tissue engineering applications are described. Different classes of such type of polymers and their blends with synthetic polymers are analysed, with special focus on polysaccharides and proteins, the systems that are more inspired by the ECM. The adaptation of conventional methods or nonconventional processing techniques for processing scaffolds from natural origin based polymers is reviewed. The use of particles, membranes and injectable systems from such kind of materials is also overviewed, especially what concerns the present status of the research that should lead towards their final application. Finally, the biological performance of tissue engineering constructs based on natural-based polymers is discussed, using several examples for different clinically relevant applications. |
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Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trendsNatural origin polymersBiomacromoleculesTissue engineeringBiomedical applicationsBiodegradableScience & TechnologyThe fields of tissue engineering and regenerative medicine aim at promoting the regeneration of tissues or replacing failing or malfunctioning organs, by means of combining a scaffold/support material, adequate cells and bioactive molecules. Different materials have been proposed to be used as both three-dimensional porous scaffolds and hydrogel matrices for distinct tissue engineering strategies. Among them, polymers of natural origin are one of the most attractive options, mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good biological performance. In this review, the most studied and promising and recently proposed naturally derived polymers that have been suggested for tissue engineering applications are described. Different classes of such type of polymers and their blends with synthetic polymers are analysed, with special focus on polysaccharides and proteins, the systems that are more inspired by the ECM. The adaptation of conventional methods or nonconventional processing techniques for processing scaffolds from natural origin based polymers is reviewed. The use of particles, membranes and injectable systems from such kind of materials is also overviewed, especially what concerns the present status of the research that should lead towards their final application. Finally, the biological performance of tissue engineering constructs based on natural-based polymers is discussed, using several examples for different clinically relevant applications.The Royal SocietyUniversidade do MinhoMano, J. F.Silva, G. A.Azevedo, Helena S.Malafaya, P. B.Sousa, R. A.Silva, Simone SantosBoesel, L. F.Oliveira, Joaquim M.Santos, T. C.Marques, A. P.Neves, N. M.Reis, R. L.20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20206eng1742-568910.1098/rsif.2007.022017412675http://dx.doi.org/10.1098/rsif.2007.0220info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:20Zoai:repositorium.sdum.uminho.pt:1822/20206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:20:46.103935Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
title |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
spellingShingle |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends Mano, J. F. Natural origin polymers Biomacromolecules Tissue engineering Biomedical applications Biodegradable Science & Technology |
title_short |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
title_full |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
title_fullStr |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
title_full_unstemmed |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
title_sort |
Natural origin biodegradable systems in tissue engineering and regenerative medicine : present status and some moving trends |
author |
Mano, J. F. |
author_facet |
Mano, J. F. Silva, G. A. Azevedo, Helena S. Malafaya, P. B. Sousa, R. A. Silva, Simone Santos Boesel, L. F. Oliveira, Joaquim M. Santos, T. C. Marques, A. P. Neves, N. M. Reis, R. L. |
author_role |
author |
author2 |
Silva, G. A. Azevedo, Helena S. Malafaya, P. B. Sousa, R. A. Silva, Simone Santos Boesel, L. F. Oliveira, Joaquim M. Santos, T. C. Marques, A. P. Neves, N. M. Reis, R. L. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Mano, J. F. Silva, G. A. Azevedo, Helena S. Malafaya, P. B. Sousa, R. A. Silva, Simone Santos Boesel, L. F. Oliveira, Joaquim M. Santos, T. C. Marques, A. P. Neves, N. M. Reis, R. L. |
dc.subject.por.fl_str_mv |
Natural origin polymers Biomacromolecules Tissue engineering Biomedical applications Biodegradable Science & Technology |
topic |
Natural origin polymers Biomacromolecules Tissue engineering Biomedical applications Biodegradable Science & Technology |
description |
The fields of tissue engineering and regenerative medicine aim at promoting the regeneration of tissues or replacing failing or malfunctioning organs, by means of combining a scaffold/support material, adequate cells and bioactive molecules. Different materials have been proposed to be used as both three-dimensional porous scaffolds and hydrogel matrices for distinct tissue engineering strategies. Among them, polymers of natural origin are one of the most attractive options, mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good biological performance. In this review, the most studied and promising and recently proposed naturally derived polymers that have been suggested for tissue engineering applications are described. Different classes of such type of polymers and their blends with synthetic polymers are analysed, with special focus on polysaccharides and proteins, the systems that are more inspired by the ECM. The adaptation of conventional methods or nonconventional processing techniques for processing scaffolds from natural origin based polymers is reviewed. The use of particles, membranes and injectable systems from such kind of materials is also overviewed, especially what concerns the present status of the research that should lead towards their final application. Finally, the biological performance of tissue engineering constructs based on natural-based polymers is discussed, using several examples for different clinically relevant applications. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 2007-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/20206 |
url |
http://hdl.handle.net/1822/20206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1742-5689 10.1098/rsif.2007.0220 17412675 http://dx.doi.org/10.1098/rsif.2007.0220 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
The Royal Society |
publisher.none.fl_str_mv |
The Royal Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132671779012608 |