Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages

Detalhes bibliográficos
Autor(a) principal: Pereira, Sara Alves
Data de Publicação: 2021
Outros Autores: Carvalho, Rui, Coelho, Pedro, Maio, Tiago, Barbosa, Renato
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48560/rspo.23931
Resumo: Macular hemorrhage is a frequent complication of retinal macroaneurysms and represents a threat to central vision. We report the surgical use of recombinant tissue plasminogen activator (rtPA) in the treatment of macular hemorrhage. Two eyes of 2 female patients with macular hemorrhage from ruptured retinal macroaneurysms were treated with subretinal rtPA injection. Visual acuities on admission were of counting fingers (<20/400) in the 2 eyes treated. Best corrected visual acuity improved to 20/100. No major intraoperative complications were reported. Macular hemorrhage presents a low rate of spontaneous resolution and, left untreated, portends a poor prognosis. Subretinal injection of rtPA is a challenging, yet effective surgical technique, with rates of hemorrhage displacement reported between 50%-90%.
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spelling Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular HemorrhagesAtivador Recombinante do Plasminogénio Tecidual no Tratamento de Hemorragia MacularComunicações Curtas e Imagens em OftalmologiaMacular hemorrhage is a frequent complication of retinal macroaneurysms and represents a threat to central vision. We report the surgical use of recombinant tissue plasminogen activator (rtPA) in the treatment of macular hemorrhage. Two eyes of 2 female patients with macular hemorrhage from ruptured retinal macroaneurysms were treated with subretinal rtPA injection. Visual acuities on admission were of counting fingers (<20/400) in the 2 eyes treated. Best corrected visual acuity improved to 20/100. No major intraoperative complications were reported. Macular hemorrhage presents a low rate of spontaneous resolution and, left untreated, portends a poor prognosis. Subretinal injection of rtPA is a challenging, yet effective surgical technique, with rates of hemorrhage displacement reported between 50%-90%.A hemorragia macular é uma complicação frequente em casos de macroaneurisma retiniano e representa uma ameaça significativa à visão central. Neste estudo, os autores reportam o uso cirúrgico de ativador recombinante do plasminogénio tecidual no tratamento de hemorragia macular. Dois olhos, de duas pacientes do sexo feminino, com hemorragia macular por rutura de macro- aneurisma retiniano foram tratados com injeção subretiniana de ativador recombinante do plasminogénio tecidual. As acuidades visuais à admissão eram de conta dedos (<20/400) nos 2 olhos tratados. As melhores acuidades visuais corrigidas melhoraram para 20/100 em cada olho tratado. Não se registaram complicações operatórias. A hemorragia macular apresenta uma baixa taxa de resolução espontânea e, na ausência de tratamento, acarreta um mau prognóstico. A injeção subretiniana de ativador recombinante do plasminogénio tecidal é uma técnica cirúrgica desafiante e eficaz, com taxas reportadas de desloca- mento da hemorragia entre os 50%-90%.Ajnet2021-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporthttps://doi.org/10.48560/rspo.23931eng1646-69501646-6950Pereira, Sara AlvesCarvalho, RuiCoelho, PedroMaio, TiagoBarbosa, Renatoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-13T20:30:15ZPortal AgregadorONG
dc.title.none.fl_str_mv Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
Ativador Recombinante do Plasminogénio Tecidual no Tratamento de Hemorragia Macular
title Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
spellingShingle Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
Pereira, Sara Alves
Comunicações Curtas e Imagens em Oftalmologia
title_short Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
title_full Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
title_fullStr Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
title_full_unstemmed Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
title_sort Recombinant Tissue Plasminogen Activator (rtPA) in the Treatment of Macular Hemorrhages
author Pereira, Sara Alves
author_facet Pereira, Sara Alves
Carvalho, Rui
Coelho, Pedro
Maio, Tiago
Barbosa, Renato
author_role author
author2 Carvalho, Rui
Coelho, Pedro
Maio, Tiago
Barbosa, Renato
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Sara Alves
Carvalho, Rui
Coelho, Pedro
Maio, Tiago
Barbosa, Renato
dc.subject.por.fl_str_mv Comunicações Curtas e Imagens em Oftalmologia
topic Comunicações Curtas e Imagens em Oftalmologia
description Macular hemorrhage is a frequent complication of retinal macroaneurysms and represents a threat to central vision. We report the surgical use of recombinant tissue plasminogen activator (rtPA) in the treatment of macular hemorrhage. Two eyes of 2 female patients with macular hemorrhage from ruptured retinal macroaneurysms were treated with subretinal rtPA injection. Visual acuities on admission were of counting fingers (<20/400) in the 2 eyes treated. Best corrected visual acuity improved to 20/100. No major intraoperative complications were reported. Macular hemorrhage presents a low rate of spontaneous resolution and, left untreated, portends a poor prognosis. Subretinal injection of rtPA is a challenging, yet effective surgical technique, with rates of hemorrhage displacement reported between 50%-90%.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48560/rspo.23931
url https://doi.org/10.48560/rspo.23931
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1646-6950
1646-6950
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ajnet
publisher.none.fl_str_mv Ajnet
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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