Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Azevedo, R. I.
Data de Publicação: 2013
Outros Autores: Soares, M. V., Albuquerque, A. S., Tendeiro, R., Soares, R. S., Martins, M., Ligeiro, D., Victorino, R. M., Lacerda, J. F., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/15884
Resumo: © 2013 American Society for Blood and Marrow Transplantation.
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spelling Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantationHematopoietic stem celltransplantationAllogenic haploidentical donorsImmune reconstitutionT cell homeostasis© 2013 American Society for Blood and Marrow Transplantation.Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assessment of immune reconstitution in a group of haploidentical HSCT recipients 4 to 6 years posttransplantation, in parallel with the respective parental donors and age-matched healthy control subjects. Our data show that the proportion of naive and memory subsets in the recipients, both within CD8(+) and CD4(+) T cells, more closely resembled that observed in age-matched control subjects than in the donors. HSCT recipients displayed relatively high signal-joint T cell-receptor excision circle levels and a high frequency of the recent thymic emigrant-enriched CD31(+) subset within naive CD4(+) and naive regulatory T cells. Moreover, CD8(+), CD4(+), and regulatory T cells from HSCT recipients displayed a diverse T cell repertoire. These results support a key role for thymic output in T cell reconstitution. Nevertheless, HSCT recipients had significantly shorter telomeres within a naive-enriched CD4(+) T cell population than age-matched control subjects, despite the similar telomere length observed within the most differentiated CD8(+) and CD4(+) T cell subsets. Overall, our data suggest that long-term immune reconstitution was successfully achieved after haploidentical HSCT, a process that appears to have largely relied on de novo T cell production.Supported by grant PTDC/SAU-MII/67662/2006 from Fundação para a Ciência e Tecnologia (FCT) and by Programa Operacional Ciência e Inovação 2010 (POCI2010) to M.V.D.S. In addition, R.I.A., A.S.A., R.T., and R.S.S. received scholarships from FCT cofinanced by POCI 2010 and FSE.ElsevierRepositório da Universidade de LisboaAzevedo, R. I.Soares, M. V.Albuquerque, A. S.Tendeiro, R.Soares, R. S.Martins, M.Ligeiro, D.Victorino, R. M.Lacerda, J. F.Sousa, A. E.2015-02-03T17:03:04Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15884engBiol Blood Marrow Transplant 19 (2013) 703-7121083-8791http://dx.doi.org/10.1016/j.bbmt.2013.01.017metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:02:48Zoai:repositorio.ul.pt:10451/15884Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:11.024876Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
title Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
spellingShingle Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
Azevedo, R. I.
Hematopoietic stem cell
transplantation
Allogenic haploidentical donors
Immune reconstitution
T cell homeostasis
title_short Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
title_full Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
title_fullStr Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
title_full_unstemmed Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
title_sort Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
author Azevedo, R. I.
author_facet Azevedo, R. I.
Soares, M. V.
Albuquerque, A. S.
Tendeiro, R.
Soares, R. S.
Martins, M.
Ligeiro, D.
Victorino, R. M.
Lacerda, J. F.
Sousa, A. E.
author_role author
author2 Soares, M. V.
Albuquerque, A. S.
Tendeiro, R.
Soares, R. S.
Martins, M.
Ligeiro, D.
Victorino, R. M.
Lacerda, J. F.
Sousa, A. E.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Azevedo, R. I.
Soares, M. V.
Albuquerque, A. S.
Tendeiro, R.
Soares, R. S.
Martins, M.
Ligeiro, D.
Victorino, R. M.
Lacerda, J. F.
Sousa, A. E.
dc.subject.por.fl_str_mv Hematopoietic stem cell
transplantation
Allogenic haploidentical donors
Immune reconstitution
T cell homeostasis
topic Hematopoietic stem cell
transplantation
Allogenic haploidentical donors
Immune reconstitution
T cell homeostasis
description © 2013 American Society for Blood and Marrow Transplantation.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2015-02-03T17:03:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/15884
url http://hdl.handle.net/10451/15884
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biol Blood Marrow Transplant 19 (2013) 703-712
1083-8791
http://dx.doi.org/10.1016/j.bbmt.2013.01.017
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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