Allogeneic hematopoietic stem cell transplantation in mycosis fungoides

• Autor(a) principal: Atalla,Angelo
• Data de Publicação: 2013
• Outros Autores: Hallack Neto,Abrahão Elias, Siqueira,Denise Bittencourt, Toledo,Gabriela Cumani
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Anais brasileiros de dermatologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000800216
• topic: Hematopoietic stem cell transplantation; Lymphoma, T-Cell, cutaneous; mycosis fungoides

Mycosis Fungoides is typically an indolent disease in early stages. However, approximately 30% of patients have advanced staged disease at presentation and 20% will develop it at some time. These patients have a poorer prognosis with a median survival of 2-4 years. The only curative option for mycosis fungoides may be hematopoietic allogeneic stem cell transplantation. We report the case of a patient with mycosis fungoides in an advanced stage (IIB), refractory to treatment options. She underwent allogeneic hematopoietic stem-cell transplantation (allo-HSCT). The patient remains in complete remission nineteen months after allo-HSCT. Allogeneic transplantation can alter the natural history of mycosis fungoides and should be considered in patients who have refractory disease or short-lived responses with standard therapies.