Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome

Detalhes bibliográficos
Autor(a) principal: Pereira, P.
Data de Publicação: 2016
Outros Autores: Rosa, S. C., Praça, C., Ferreira, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/41573
Resumo: Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014
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spelling Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria SyndromeVascular cellsInduced pluripotent stem cellsProgeria diseaseDrug modelingDrug screeningScience & TechnologyTransparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014Induced pluripotent stem cells (iPSCs) represent today an invaluable tool to create disease cell models for modeling and drug screening. Several lines of iPSCs have been generated in the last 7 years that changed the paradigm for studying diseases and the discovery of new drugs to treat them. In this article we focus our attention to vascular diseases in particular Hutchinson-Gilford Progeria Syndrome (HGPS), a devastating premature aging disease caused by a mutation in the lamin A gene. In general, patients die because of myocardial infarction or stroke. Because the patients are fragile the isolation of a particular type of cells is very difficult. Therefore in the last 5 years, researchers have used cells derived from iPSCs to model aspects of the HGPS and to screen libraries of chemicals to retard or treat the disease.This work was supported by Fundação para a Ciência e a Tecnologia (PTDC/SAU-TOX/121887/2010; SFRH/BD/71042/2010; SFRH/BD/51678/2011; SFRH/BPD/79323/2011) and COMPETE funding (Project “Stem cell based platforms for Regenerative and Therapeutic Medicine”, Centro-07-ST24-FEDER-002008). The authors declare no conflict of interest to disclose.ElsevierUniversidade do MinhoPereira, P.Rosa, S. C.Praça, C.Ferreira, L.2016-05-062016-05-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/41573engPereira, P.; Rosa, S. C.; Praça, C.; Ferreira, L., Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome. Biochemical and Biophysical Research Communications, 473(3), 710-718, 20160006-291X1090-210410.1016/j.bbrc.2015.10.01426474704http://www.elsevier.com/locate/issn/0006291Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:40ZPortal AgregadorONG
dc.title.none.fl_str_mv Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
title Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
spellingShingle Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
Pereira, P.
Vascular cells
Induced pluripotent stem cells
Progeria disease
Drug modeling
Drug screening
Science & Technology
title_short Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
title_full Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
title_fullStr Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
title_full_unstemmed Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
title_sort Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome
author Pereira, P.
author_facet Pereira, P.
Rosa, S. C.
Praça, C.
Ferreira, L.
author_role author
author2 Rosa, S. C.
Praça, C.
Ferreira, L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pereira, P.
Rosa, S. C.
Praça, C.
Ferreira, L.
dc.subject.por.fl_str_mv Vascular cells
Induced pluripotent stem cells
Progeria disease
Drug modeling
Drug screening
Science & Technology
topic Vascular cells
Induced pluripotent stem cells
Progeria disease
Drug modeling
Drug screening
Science & Technology
description Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014
publishDate 2016
dc.date.none.fl_str_mv 2016-05-06
2016-05-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/41573
url http://hdl.handle.net/1822/41573
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, P.; Rosa, S. C.; Praça, C.; Ferreira, L., Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome. Biochemical and Biophysical Research Communications, 473(3), 710-718, 2016
0006-291X
1090-2104
10.1016/j.bbrc.2015.10.014
26474704
http://www.elsevier.com/locate/issn/0006291X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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