Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023 |
Resumo: | Objectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD.Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1 st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS).Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD.Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD. |
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Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
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Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiencyIdiopathic short staturegrowth hormone therapygrowth hormone deficiencypartial GH insensitivityObjectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD.Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1 st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS).Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD.Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD.Sociedade Brasileira de Endocrinologia e Metabologia2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.1 2014reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/0004-2730000002793info:eu-repo/semantics/openAccessCardoso,Daniela F.Martinelli Jr.,Carlos EduardoCampos,Viviane C.Gomes,Elenilde S.Rocha,Ívina E. S.Oliveira,Carla R. P.Vicente,Taisa A. R.Pereira,Rossana M. C.Pereira,Francisco A.Cartaxo,Carla K. A.Milani,Soraya L. S.Oliveira,Mario C. P.Melo,Enaldo V.Oliveira,Andre L. P.Aguiar-Oliveira,Manuel H.eng2014-03-28T00:00:00Zoai:scielo:S0004-27302014000100023Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2014-03-28T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
spellingShingle |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency Cardoso,Daniela F. Idiopathic short stature growth hormone therapy growth hormone deficiency partial GH insensitivity |
title_short |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_full |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_fullStr |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_full_unstemmed |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_sort |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
author |
Cardoso,Daniela F. |
author_facet |
Cardoso,Daniela F. Martinelli Jr.,Carlos Eduardo Campos,Viviane C. Gomes,Elenilde S. Rocha,Ívina E. S. Oliveira,Carla R. P. Vicente,Taisa A. R. Pereira,Rossana M. C. Pereira,Francisco A. Cartaxo,Carla K. A. Milani,Soraya L. S. Oliveira,Mario C. P. Melo,Enaldo V. Oliveira,Andre L. P. Aguiar-Oliveira,Manuel H. |
author_role |
author |
author2 |
Martinelli Jr.,Carlos Eduardo Campos,Viviane C. Gomes,Elenilde S. Rocha,Ívina E. S. Oliveira,Carla R. P. Vicente,Taisa A. R. Pereira,Rossana M. C. Pereira,Francisco A. Cartaxo,Carla K. A. Milani,Soraya L. S. Oliveira,Mario C. P. Melo,Enaldo V. Oliveira,Andre L. P. Aguiar-Oliveira,Manuel H. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso,Daniela F. Martinelli Jr.,Carlos Eduardo Campos,Viviane C. Gomes,Elenilde S. Rocha,Ívina E. S. Oliveira,Carla R. P. Vicente,Taisa A. R. Pereira,Rossana M. C. Pereira,Francisco A. Cartaxo,Carla K. A. Milani,Soraya L. S. Oliveira,Mario C. P. Melo,Enaldo V. Oliveira,Andre L. P. Aguiar-Oliveira,Manuel H. |
dc.subject.por.fl_str_mv |
Idiopathic short stature growth hormone therapy growth hormone deficiency partial GH insensitivity |
topic |
Idiopathic short stature growth hormone therapy growth hormone deficiency partial GH insensitivity |
description |
Objectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD.Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1 st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS).Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD.Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-2730000002793 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.1 2014 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734812614098944 |