Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1753 |
Resumo: | Objectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS). Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD. Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD. _________________________________________________________________________________________ RESUMO: Objetivos: O tratamento com GH é ainda controverso, salvo na deficiência grave de GH (SGHD). O objetivo deste estudo foi comparar a resposta ao tratamento com GH em indivíduos com insensibilidade parcial ao GH (PGHIS) e na deficiência moderada do GH (MGHD) com SGHD. Sujeitos e métodos: Quinze pacientes com PGHIS, 11 com MGHD e 19 com SGHD, seguidos por mais de um ano no Sistema Único de Saúde, foram avaliados antropométrica e laboratorialmente, no início, com um ano de tratamento e na última avaliação (tempo máximo de dez anos na SGHD, quatro anos na MGHD e oito anos na PGHIS). Resultados: O escore de desvio-padrão (EDP) da estatura inicial foi menor nos indivíduos com SGHD do que naqueles com MGHD e PGHIS. Embora o aumento no EDP da estatura no primeiro ano em comparação com o inicial não fosse diferente entre os grupos, o EDP da altura no primeiro ano de tratamento permaneceu menor na SGHD que na MGHD. Não houve diferença no EDP da estatura na última avaliação entre os três grupos. O tratamento com GH, no período completo da observação, provocou uma tendência a menor aumento no EDP da estatura nos pacientes com PGHIS que naqueles com SGHD, entretanto aumentos semelhantes foram encontrados nos grupos MGHD e SGHD. Conclusão: O tratamento com GH aumentou a estatura nos indivíduos com PGHIS e produziu efeitos similares na estatura em MGHD e SGHD. |
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Cardoso, Daniela FelixMartinelli Junior, Carlos EduardoCampos, Viviane CorreiaSantos, Elenilde GomesRocha, Ivina Elaine dos SantosOliveira, Carla Raquel PereiraVicente, Tábita de Almeida RibeiroPereira, Rossana Maria CahinoPereira, Francisco de AssisCartaxo, Carla Kalline AlvesMilani, Soraya Lopes SaderOliveira, Mario C. P.Melo, Enaldo Vieira deOliveira, André L. P.Oliveira, Manuel Herminio de Aguiar2016-04-11T13:25:35Z2016-04-11T13:25:35Z2014-02CARDOSO, D. F. et al. Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency. Arquivos Brasileiros de Endocrinologia & Metabologia, São Paulo, v. 58, n. 1, fev. 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023#aff1>. Acesso em: 11 abr. 2016.1677-9487https://ri.ufs.br/handle/riufs/1753Creative Commons Attribution Non-Commercial LicenseObjectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS). Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD. Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD. _________________________________________________________________________________________ RESUMO: Objetivos: O tratamento com GH é ainda controverso, salvo na deficiência grave de GH (SGHD). O objetivo deste estudo foi comparar a resposta ao tratamento com GH em indivíduos com insensibilidade parcial ao GH (PGHIS) e na deficiência moderada do GH (MGHD) com SGHD. Sujeitos e métodos: Quinze pacientes com PGHIS, 11 com MGHD e 19 com SGHD, seguidos por mais de um ano no Sistema Único de Saúde, foram avaliados antropométrica e laboratorialmente, no início, com um ano de tratamento e na última avaliação (tempo máximo de dez anos na SGHD, quatro anos na MGHD e oito anos na PGHIS). Resultados: O escore de desvio-padrão (EDP) da estatura inicial foi menor nos indivíduos com SGHD do que naqueles com MGHD e PGHIS. Embora o aumento no EDP da estatura no primeiro ano em comparação com o inicial não fosse diferente entre os grupos, o EDP da altura no primeiro ano de tratamento permaneceu menor na SGHD que na MGHD. Não houve diferença no EDP da estatura na última avaliação entre os três grupos. O tratamento com GH, no período completo da observação, provocou uma tendência a menor aumento no EDP da estatura nos pacientes com PGHIS que naqueles com SGHD, entretanto aumentos semelhantes foram encontrados nos grupos MGHD e SGHD. Conclusão: O tratamento com GH aumentou a estatura nos indivíduos com PGHIS e produziu efeitos similares na estatura em MGHD e SGHD.Sociedade Brasileira de Endocrinologia e MetabologiaIdiopathic short statureGrowth hormone therapyGrowth hormone deficiencyPartial GH insensitivityBaixa estatura idiopáticaTratamento com hormônio do crescimentoDeficiência de hormônio do crescimentoInsensibilidade parcial ao GHComparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiencyComparação entre a resposta de crescimento ao tratamento com hormônio de crescimento (GH) em crianças com insensibilidade parcial ao GH ou deficiência de GH leveinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILGHTherapyChildren.pdf.jpgGHTherapyChildren.pdf.jpgGenerated Thumbnailimage/jpeg1653https://ri.ufs.br/jspui/bitstream/riufs/1753/4/GHTherapyChildren.pdf.jpg40ab960450f79dcf2505bb96073db9b5MD54ORIGINALGHTherapyChildren.pdfGHTherapyChildren.pdfapplication/pdf112423https://ri.ufs.br/jspui/bitstream/riufs/1753/1/GHTherapyChildren.pdf5a88a8f5a7506aed924864d187ad956fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1753/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTGHTherapyChildren.pdf.txtGHTherapyChildren.pdf.txtExtracted texttext/plain34917https://ri.ufs.br/jspui/bitstream/riufs/1753/3/GHTherapyChildren.pdf.txte0d351787c3a6d4cf13f8927694e547cMD53riufs/17532017-11-20 19:06:36.701oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-20T22:06:36Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
dc.title.alternative.pt_BR.fl_str_mv |
Comparação entre a resposta de crescimento ao tratamento com hormônio de crescimento (GH) em crianças com insensibilidade parcial ao GH ou deficiência de GH leve |
title |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
spellingShingle |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency Cardoso, Daniela Felix Idiopathic short stature Growth hormone therapy Growth hormone deficiency Partial GH insensitivity Baixa estatura idiopática Tratamento com hormônio do crescimento Deficiência de hormônio do crescimento Insensibilidade parcial ao GH |
title_short |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_full |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_fullStr |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_full_unstemmed |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
title_sort |
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency |
author |
Cardoso, Daniela Felix |
author_facet |
Cardoso, Daniela Felix Martinelli Junior, Carlos Eduardo Campos, Viviane Correia Santos, Elenilde Gomes Rocha, Ivina Elaine dos Santos Oliveira, Carla Raquel Pereira Vicente, Tábita de Almeida Ribeiro Pereira, Rossana Maria Cahino Pereira, Francisco de Assis Cartaxo, Carla Kalline Alves Milani, Soraya Lopes Sader Oliveira, Mario C. P. Melo, Enaldo Vieira de Oliveira, André L. P. Oliveira, Manuel Herminio de Aguiar |
author_role |
author |
author2 |
Martinelli Junior, Carlos Eduardo Campos, Viviane Correia Santos, Elenilde Gomes Rocha, Ivina Elaine dos Santos Oliveira, Carla Raquel Pereira Vicente, Tábita de Almeida Ribeiro Pereira, Rossana Maria Cahino Pereira, Francisco de Assis Cartaxo, Carla Kalline Alves Milani, Soraya Lopes Sader Oliveira, Mario C. P. Melo, Enaldo Vieira de Oliveira, André L. P. Oliveira, Manuel Herminio de Aguiar |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso, Daniela Felix Martinelli Junior, Carlos Eduardo Campos, Viviane Correia Santos, Elenilde Gomes Rocha, Ivina Elaine dos Santos Oliveira, Carla Raquel Pereira Vicente, Tábita de Almeida Ribeiro Pereira, Rossana Maria Cahino Pereira, Francisco de Assis Cartaxo, Carla Kalline Alves Milani, Soraya Lopes Sader Oliveira, Mario C. P. Melo, Enaldo Vieira de Oliveira, André L. P. Oliveira, Manuel Herminio de Aguiar |
dc.subject.por.fl_str_mv |
Idiopathic short stature Growth hormone therapy Growth hormone deficiency Partial GH insensitivity Baixa estatura idiopática Tratamento com hormônio do crescimento Deficiência de hormônio do crescimento Insensibilidade parcial ao GH |
topic |
Idiopathic short stature Growth hormone therapy Growth hormone deficiency Partial GH insensitivity Baixa estatura idiopática Tratamento com hormônio do crescimento Deficiência de hormônio do crescimento Insensibilidade parcial ao GH |
description |
Objectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS). Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD. Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD. _________________________________________________________________________________________ RESUMO: Objetivos: O tratamento com GH é ainda controverso, salvo na deficiência grave de GH (SGHD). O objetivo deste estudo foi comparar a resposta ao tratamento com GH em indivíduos com insensibilidade parcial ao GH (PGHIS) e na deficiência moderada do GH (MGHD) com SGHD. Sujeitos e métodos: Quinze pacientes com PGHIS, 11 com MGHD e 19 com SGHD, seguidos por mais de um ano no Sistema Único de Saúde, foram avaliados antropométrica e laboratorialmente, no início, com um ano de tratamento e na última avaliação (tempo máximo de dez anos na SGHD, quatro anos na MGHD e oito anos na PGHIS). Resultados: O escore de desvio-padrão (EDP) da estatura inicial foi menor nos indivíduos com SGHD do que naqueles com MGHD e PGHIS. Embora o aumento no EDP da estatura no primeiro ano em comparação com o inicial não fosse diferente entre os grupos, o EDP da altura no primeiro ano de tratamento permaneceu menor na SGHD que na MGHD. Não houve diferença no EDP da estatura na última avaliação entre os três grupos. O tratamento com GH, no período completo da observação, provocou uma tendência a menor aumento no EDP da estatura nos pacientes com PGHIS que naqueles com SGHD, entretanto aumentos semelhantes foram encontrados nos grupos MGHD e SGHD. Conclusão: O tratamento com GH aumentou a estatura nos indivíduos com PGHIS e produziu efeitos similares na estatura em MGHD e SGHD. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-02 |
dc.date.accessioned.fl_str_mv |
2016-04-11T13:25:35Z |
dc.date.available.fl_str_mv |
2016-04-11T13:25:35Z |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
CARDOSO, D. F. et al. Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency. Arquivos Brasileiros de Endocrinologia & Metabologia, São Paulo, v. 58, n. 1, fev. 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023#aff1>. Acesso em: 11 abr. 2016. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1753 |
dc.identifier.issn.none.fl_str_mv |
1677-9487 |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution Non-Commercial License |
identifier_str_mv |
CARDOSO, D. F. et al. Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency. Arquivos Brasileiros de Endocrinologia & Metabologia, São Paulo, v. 58, n. 1, fev. 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000100023#aff1>. Acesso em: 11 abr. 2016. 1677-9487 Creative Commons Attribution Non-Commercial License |
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https://ri.ufs.br/handle/riufs/1753 |
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openAccess |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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