Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600903 |
Resumo: | The organic extract EB689, obtained from the stem of Abarema auriculata (Benth.) Barneby & J.W.Grimes, Fabaceae, commonly known as "saboeiro-ferro", was chemically studied, as well as its influence over behavioral effects such as locomotion, emotionality and anxiety, after intra-peritonial administration were assessed. The open-field and elevated-plus maze were used in experiments divided into two stages. The first stage aimed for the identification of the main effects over behavior using a reduced number of animals against half-fold diluted doses of EB689. The same variables were also tested in a second stage of the experiment using the non-lethal intra-peritoneal dose of 4.8 mg/kg in a larger number of animals. It was observed that EB689 clearly decreased locomotion, which was probably caused by internal hemorrhage causing hypovolemic shock. Although it is the first time lupeol and eucryphin are described in A. auriculata, it is still not clear if they are involved in the toxicology of A. auriculata. The undesirable effects of EB689 are better understood, the basis for further pharmacological assays aiming antitumor activity are supported. |
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Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behaviorAbarema auriculataSaboeiro-ferroAmazon rain forestBehaviorOpen fieldElevated plus mazeThe organic extract EB689, obtained from the stem of Abarema auriculata (Benth.) Barneby & J.W.Grimes, Fabaceae, commonly known as "saboeiro-ferro", was chemically studied, as well as its influence over behavioral effects such as locomotion, emotionality and anxiety, after intra-peritonial administration were assessed. The open-field and elevated-plus maze were used in experiments divided into two stages. The first stage aimed for the identification of the main effects over behavior using a reduced number of animals against half-fold diluted doses of EB689. The same variables were also tested in a second stage of the experiment using the non-lethal intra-peritoneal dose of 4.8 mg/kg in a larger number of animals. It was observed that EB689 clearly decreased locomotion, which was probably caused by internal hemorrhage causing hypovolemic shock. Although it is the first time lupeol and eucryphin are described in A. auriculata, it is still not clear if they are involved in the toxicology of A. auriculata. The undesirable effects of EB689 are better understood, the basis for further pharmacological assays aiming antitumor activity are supported.Sociedade Brasileira de Farmacognosia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600903Revista Brasileira de Farmacognosia v.23 n.6 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013000600007info:eu-repo/semantics/openAccessGusmão,Daniela F.Estork,Dirce M.Paciencia,Mateus L.B.Díaz,Ingrit E.C.Montero,Edna F.S.Varella,Antonio DrauzioReis,Luiz Fernando LimaYounes,Riad N.Suffredini,Ivana B.Bernardi,Maria M.eng2015-10-09T00:00:00Zoai:scielo:S0102-695X2013000600903Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-10-09T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
title |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
spellingShingle |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior Gusmão,Daniela F. Abarema auriculata Saboeiro-ferro Amazon rain forest Behavior Open field Elevated plus maze |
title_short |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
title_full |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
title_fullStr |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
title_full_unstemmed |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
title_sort |
Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior |
author |
Gusmão,Daniela F. |
author_facet |
Gusmão,Daniela F. Estork,Dirce M. Paciencia,Mateus L.B. Díaz,Ingrit E.C. Montero,Edna F.S. Varella,Antonio Drauzio Reis,Luiz Fernando Lima Younes,Riad N. Suffredini,Ivana B. Bernardi,Maria M. |
author_role |
author |
author2 |
Estork,Dirce M. Paciencia,Mateus L.B. Díaz,Ingrit E.C. Montero,Edna F.S. Varella,Antonio Drauzio Reis,Luiz Fernando Lima Younes,Riad N. Suffredini,Ivana B. Bernardi,Maria M. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gusmão,Daniela F. Estork,Dirce M. Paciencia,Mateus L.B. Díaz,Ingrit E.C. Montero,Edna F.S. Varella,Antonio Drauzio Reis,Luiz Fernando Lima Younes,Riad N. Suffredini,Ivana B. Bernardi,Maria M. |
dc.subject.por.fl_str_mv |
Abarema auriculata Saboeiro-ferro Amazon rain forest Behavior Open field Elevated plus maze |
topic |
Abarema auriculata Saboeiro-ferro Amazon rain forest Behavior Open field Elevated plus maze |
description |
The organic extract EB689, obtained from the stem of Abarema auriculata (Benth.) Barneby & J.W.Grimes, Fabaceae, commonly known as "saboeiro-ferro", was chemically studied, as well as its influence over behavioral effects such as locomotion, emotionality and anxiety, after intra-peritonial administration were assessed. The open-field and elevated-plus maze were used in experiments divided into two stages. The first stage aimed for the identification of the main effects over behavior using a reduced number of animals against half-fold diluted doses of EB689. The same variables were also tested in a second stage of the experiment using the non-lethal intra-peritoneal dose of 4.8 mg/kg in a larger number of animals. It was observed that EB689 clearly decreased locomotion, which was probably caused by internal hemorrhage causing hypovolemic shock. Although it is the first time lupeol and eucryphin are described in A. auriculata, it is still not clear if they are involved in the toxicology of A. auriculata. The undesirable effects of EB689 are better understood, the basis for further pharmacological assays aiming antitumor activity are supported. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600903 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600903 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2013000600007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.23 n.6 2013 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122468431036416 |