Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000400398 |
Resumo: | Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control; for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses; however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniques. |
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Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasisVaccine. Visceral leishmaniasisRecombinant proteinsImmuno-proteomic approachHypothetical proteins.Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control; for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses; however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniques.Sociedade Brasileira de Medicina Tropical - SBMT2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000400398Revista da Sociedade Brasileira de Medicina Tropical v.49 n.4 2016reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0120-2016info:eu-repo/semantics/openAccessDuarte,Mariana CostaLage,Daniela PagliaraMartins,Vívian TamiettiChávez-Fumagalli,Miguel AngelRoatt,Bruno MendesMenezes-Souza,DanielGoulart,Luiz RicardoSoto,ManuelTavares,Carlos Alberto PereiraCoelho,Eduardo Antonio Ferrazeng2016-08-29T00:00:00Zoai:scielo:S0037-86822016000400398Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2016-08-29T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
title |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
spellingShingle |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis Duarte,Mariana Costa Vaccine. Visceral leishmaniasis Recombinant proteins Immuno-proteomic approach Hypothetical proteins. |
title_short |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
title_full |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
title_fullStr |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
title_full_unstemmed |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
title_sort |
Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis |
author |
Duarte,Mariana Costa |
author_facet |
Duarte,Mariana Costa Lage,Daniela Pagliara Martins,Vívian Tamietti Chávez-Fumagalli,Miguel Angel Roatt,Bruno Mendes Menezes-Souza,Daniel Goulart,Luiz Ricardo Soto,Manuel Tavares,Carlos Alberto Pereira Coelho,Eduardo Antonio Ferraz |
author_role |
author |
author2 |
Lage,Daniela Pagliara Martins,Vívian Tamietti Chávez-Fumagalli,Miguel Angel Roatt,Bruno Mendes Menezes-Souza,Daniel Goulart,Luiz Ricardo Soto,Manuel Tavares,Carlos Alberto Pereira Coelho,Eduardo Antonio Ferraz |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Duarte,Mariana Costa Lage,Daniela Pagliara Martins,Vívian Tamietti Chávez-Fumagalli,Miguel Angel Roatt,Bruno Mendes Menezes-Souza,Daniel Goulart,Luiz Ricardo Soto,Manuel Tavares,Carlos Alberto Pereira Coelho,Eduardo Antonio Ferraz |
dc.subject.por.fl_str_mv |
Vaccine. Visceral leishmaniasis Recombinant proteins Immuno-proteomic approach Hypothetical proteins. |
topic |
Vaccine. Visceral leishmaniasis Recombinant proteins Immuno-proteomic approach Hypothetical proteins. |
description |
Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control; for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses; however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniques. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000400398 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000400398 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0120-2016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.49 n.4 2016 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122160481042432 |