Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity
Autor(a) principal: | |
---|---|
Data de Publicação: | 1991 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005 |
Resumo: | It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment |
id |
SBMT-1_c32ccb366e5e1edacd98aa102114eae3 |
---|---|
oai_identifier_str |
oai:scielo:S0037-86821991000200005 |
network_acronym_str |
SBMT-1 |
network_name_str |
Revista da Sociedade Brasileira de Medicina Tropical |
repository_id_str |
|
spelling |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivityImmunodepressionSchistosomiasisOxamniquineIt has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatmentSociedade Brasileira de Medicina Tropical - SBMT1991-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005Revista da Sociedade Brasileira de Medicina Tropical v.24 n.2 1991reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821991000200005info:eu-repo/semantics/openAccessMuniz-Junqueira,Maria ImaculadaTavares-Neto,JoséAtaide,MeirePrata,AluizioTosta,Carlos Eduardoeng2013-05-15T00:00:00Zoai:scielo:S0037-86821991000200005Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-05-15T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
spellingShingle |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity Muniz-Junqueira,Maria Imaculada Immunodepression Schistosomiasis Oxamniquine |
title_short |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_full |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_fullStr |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_full_unstemmed |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_sort |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
author |
Muniz-Junqueira,Maria Imaculada |
author_facet |
Muniz-Junqueira,Maria Imaculada Tavares-Neto,José Ataide,Meire Prata,Aluizio Tosta,Carlos Eduardo |
author_role |
author |
author2 |
Tavares-Neto,José Ataide,Meire Prata,Aluizio Tosta,Carlos Eduardo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Muniz-Junqueira,Maria Imaculada Tavares-Neto,José Ataide,Meire Prata,Aluizio Tosta,Carlos Eduardo |
dc.subject.por.fl_str_mv |
Immunodepression Schistosomiasis Oxamniquine |
topic |
Immunodepression Schistosomiasis Oxamniquine |
description |
It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment |
publishDate |
1991 |
dc.date.none.fl_str_mv |
1991-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86821991000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.24 n.2 1991 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122149092458496 |