An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000300400 |
Resumo: | Abstract Advanced age is a risk factor for severe infection by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children, however, often present with milder manifestations of Coronavirus Disease 2019 (COVID-19). Associations have been found between COVID-19 and multisystem inflammatory syndrome in children (MIS-C). Patients with the latter condition present more severe involvement. Adults with comorbidities such as chronic kidney disease (CKD) are more severely affected. This narrative review aimed to look into whether CKD contributed to more severe involvement in pediatric patients with COVID-19. The studies included in this review did not report severe cases or deaths, and indicated that pediatric patients with CKD and previously healthy children recovered quickly from infection. However, some patients with MIS-C required hospitalization in intensive care units and a few died, although it was not possible to correlate MIS-C and CKD. Conversely, adults with CKD reportedly had increased risk of severe infection by SARS-CoV-2 and higher death rates. The discrepancies seen between age groups may be due to immune system and renin-angiotensin system differences, with more pronounced expression of ACE2 in children. Immunosuppressant therapy has not been related with positive or negative effects in individuals with COVID-19, although current recommendations establish decreases in the dosage of some medications. To sum up with, CKD was not associated with more severe involvement in children diagnosed with COVID-19. Studies enrolling larger populations are still required. |
id |
SBN-1_8a81dee7a727c2d17ce3b2b1b781104c |
---|---|
oai_identifier_str |
oai:scielo:S0101-28002021000300400 |
network_acronym_str |
SBN-1 |
network_name_str |
Jornal Brasileiro de Nefrologia |
repository_id_str |
|
spelling |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19Coronavirus InfectionsRenal Insufficiency, ChronicChildPrognosisAbstract Advanced age is a risk factor for severe infection by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children, however, often present with milder manifestations of Coronavirus Disease 2019 (COVID-19). Associations have been found between COVID-19 and multisystem inflammatory syndrome in children (MIS-C). Patients with the latter condition present more severe involvement. Adults with comorbidities such as chronic kidney disease (CKD) are more severely affected. This narrative review aimed to look into whether CKD contributed to more severe involvement in pediatric patients with COVID-19. The studies included in this review did not report severe cases or deaths, and indicated that pediatric patients with CKD and previously healthy children recovered quickly from infection. However, some patients with MIS-C required hospitalization in intensive care units and a few died, although it was not possible to correlate MIS-C and CKD. Conversely, adults with CKD reportedly had increased risk of severe infection by SARS-CoV-2 and higher death rates. The discrepancies seen between age groups may be due to immune system and renin-angiotensin system differences, with more pronounced expression of ACE2 in children. Immunosuppressant therapy has not been related with positive or negative effects in individuals with COVID-19, although current recommendations establish decreases in the dosage of some medications. To sum up with, CKD was not associated with more severe involvement in children diagnosed with COVID-19. Studies enrolling larger populations are still required.Sociedade Brasileira de Nefrologia2021-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000300400Brazilian Journal of Nephrology v.43 n.3 2021reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2020-0208info:eu-repo/semantics/openAccessFaria,Bárbara Caroline DiasSacramento,Luiz Gustavo GuimarãesFilipin,Carolina Sant’ AnnaCruz,Aniel Feitosa daNagata,Sarah NaomiSilva,Ana Cristina Simões eeng2021-11-05T00:00:00Zoai:scielo:S0101-28002021000300400Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2021-11-05T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
title |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
spellingShingle |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 Faria,Bárbara Caroline Dias Coronavirus Infections Renal Insufficiency, Chronic Child Prognosis |
title_short |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
title_full |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
title_fullStr |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
title_full_unstemmed |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
title_sort |
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19 |
author |
Faria,Bárbara Caroline Dias |
author_facet |
Faria,Bárbara Caroline Dias Sacramento,Luiz Gustavo Guimarães Filipin,Carolina Sant’ Anna Cruz,Aniel Feitosa da Nagata,Sarah Naomi Silva,Ana Cristina Simões e |
author_role |
author |
author2 |
Sacramento,Luiz Gustavo Guimarães Filipin,Carolina Sant’ Anna Cruz,Aniel Feitosa da Nagata,Sarah Naomi Silva,Ana Cristina Simões e |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Faria,Bárbara Caroline Dias Sacramento,Luiz Gustavo Guimarães Filipin,Carolina Sant’ Anna Cruz,Aniel Feitosa da Nagata,Sarah Naomi Silva,Ana Cristina Simões e |
dc.subject.por.fl_str_mv |
Coronavirus Infections Renal Insufficiency, Chronic Child Prognosis |
topic |
Coronavirus Infections Renal Insufficiency, Chronic Child Prognosis |
description |
Abstract Advanced age is a risk factor for severe infection by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children, however, often present with milder manifestations of Coronavirus Disease 2019 (COVID-19). Associations have been found between COVID-19 and multisystem inflammatory syndrome in children (MIS-C). Patients with the latter condition present more severe involvement. Adults with comorbidities such as chronic kidney disease (CKD) are more severely affected. This narrative review aimed to look into whether CKD contributed to more severe involvement in pediatric patients with COVID-19. The studies included in this review did not report severe cases or deaths, and indicated that pediatric patients with CKD and previously healthy children recovered quickly from infection. However, some patients with MIS-C required hospitalization in intensive care units and a few died, although it was not possible to correlate MIS-C and CKD. Conversely, adults with CKD reportedly had increased risk of severe infection by SARS-CoV-2 and higher death rates. The discrepancies seen between age groups may be due to immune system and renin-angiotensin system differences, with more pronounced expression of ACE2 in children. Immunosuppressant therapy has not been related with positive or negative effects in individuals with COVID-19, although current recommendations establish decreases in the dosage of some medications. To sum up with, CKD was not associated with more severe involvement in children diagnosed with COVID-19. Studies enrolling larger populations are still required. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000300400 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000300400 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-2020-0208 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.43 n.3 2021 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
_version_ |
1752122066943868928 |