Height and sexual maturation in girls with juvenile idiopathic arthritis

Bibliographic Details
Main Author: Machado,Sandra Helena
Publication Date: 2020
Other Authors: Xavier,Ricardo M., Lora,Priscila S., Gonçalves,Luciana M. Kurtz, Trindade,Luciane R., Marostica,Paulo José C.
Format: Article
Language: eng
Source: Jornal de Pediatria (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100100
Summary: Abstract Objective To evaluate height, sexual maturation, and the difference between final and expected height in girls with juvenile idiopathic arthritis and no glucocorticoid treatment for at least six months, as compared to a group of healthy girls. Methods This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases. Demographic data were collected from all participants, and disease and treatment variables were compiled for the patient group. Anthropometric measurements were converted into Z-scores based on World Health Organization standards. Sexual maturation was classified according to Tanner stages. Results Body mass index and height Z-scores were lower in girls with juvenile idiopathic arthritis as compared to control participants. These values differed significantly in Tanner stage II. Three (6.8%) girls with juvenile idiopathic arthritis had height-for-age Z-scores <−2 (short stature). Girls with polyarticular juvenile idiopathic arthritis and higher cumulative glucocorticoid doses were significantly more likely to present with short stature. The percentage of prepubertal girls in the juvenile idiopathic arthritis group was significantly higher than that observed in the control group, (p = 0.012). Age of menarche, adult height, and the difference between actual and expected height did not differ between groups. Conclusion These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty.
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spelling Height and sexual maturation in girls with juvenile idiopathic arthritisJuvenile idiopathic arthritisPubertyHeightMenarcheAbstract Objective To evaluate height, sexual maturation, and the difference between final and expected height in girls with juvenile idiopathic arthritis and no glucocorticoid treatment for at least six months, as compared to a group of healthy girls. Methods This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases. Demographic data were collected from all participants, and disease and treatment variables were compiled for the patient group. Anthropometric measurements were converted into Z-scores based on World Health Organization standards. Sexual maturation was classified according to Tanner stages. Results Body mass index and height Z-scores were lower in girls with juvenile idiopathic arthritis as compared to control participants. These values differed significantly in Tanner stage II. Three (6.8%) girls with juvenile idiopathic arthritis had height-for-age Z-scores <−2 (short stature). Girls with polyarticular juvenile idiopathic arthritis and higher cumulative glucocorticoid doses were significantly more likely to present with short stature. The percentage of prepubertal girls in the juvenile idiopathic arthritis group was significantly higher than that observed in the control group, (p = 0.012). Age of menarche, adult height, and the difference between actual and expected height did not differ between groups. Conclusion These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty.Sociedade Brasileira de Pediatria2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100100Jornal de Pediatria v.96 n.1 2020reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.07.015info:eu-repo/semantics/openAccessMachado,Sandra HelenaXavier,Ricardo M.Lora,Priscila S.Gonçalves,Luciana M. KurtzTrindade,Luciane R.Marostica,Paulo José C.eng2020-02-28T00:00:00Zoai:scielo:S0021-75572020000100100Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2020-02-28T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Height and sexual maturation in girls with juvenile idiopathic arthritis
title Height and sexual maturation in girls with juvenile idiopathic arthritis
spellingShingle Height and sexual maturation in girls with juvenile idiopathic arthritis
Machado,Sandra Helena
Juvenile idiopathic arthritis
Puberty
Height
Menarche
title_short Height and sexual maturation in girls with juvenile idiopathic arthritis
title_full Height and sexual maturation in girls with juvenile idiopathic arthritis
title_fullStr Height and sexual maturation in girls with juvenile idiopathic arthritis
title_full_unstemmed Height and sexual maturation in girls with juvenile idiopathic arthritis
title_sort Height and sexual maturation in girls with juvenile idiopathic arthritis
author Machado,Sandra Helena
author_facet Machado,Sandra Helena
Xavier,Ricardo M.
Lora,Priscila S.
Gonçalves,Luciana M. Kurtz
Trindade,Luciane R.
Marostica,Paulo José C.
author_role author
author2 Xavier,Ricardo M.
Lora,Priscila S.
Gonçalves,Luciana M. Kurtz
Trindade,Luciane R.
Marostica,Paulo José C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Machado,Sandra Helena
Xavier,Ricardo M.
Lora,Priscila S.
Gonçalves,Luciana M. Kurtz
Trindade,Luciane R.
Marostica,Paulo José C.
dc.subject.por.fl_str_mv Juvenile idiopathic arthritis
Puberty
Height
Menarche
topic Juvenile idiopathic arthritis
Puberty
Height
Menarche
description Abstract Objective To evaluate height, sexual maturation, and the difference between final and expected height in girls with juvenile idiopathic arthritis and no glucocorticoid treatment for at least six months, as compared to a group of healthy girls. Methods This cross-sectional study involved 44 girls with juvenile idiopathic arthritis, diagnosed according to the International League of Associations for Rheumatology criteria, and 59 healthy controls aged between 8 and 18 (incomplete) years with no comorbid chronic diseases. Demographic data were collected from all participants, and disease and treatment variables were compiled for the patient group. Anthropometric measurements were converted into Z-scores based on World Health Organization standards. Sexual maturation was classified according to Tanner stages. Results Body mass index and height Z-scores were lower in girls with juvenile idiopathic arthritis as compared to control participants. These values differed significantly in Tanner stage II. Three (6.8%) girls with juvenile idiopathic arthritis had height-for-age Z-scores <−2 (short stature). Girls with polyarticular juvenile idiopathic arthritis and higher cumulative glucocorticoid doses were significantly more likely to present with short stature. The percentage of prepubertal girls in the juvenile idiopathic arthritis group was significantly higher than that observed in the control group, (p = 0.012). Age of menarche, adult height, and the difference between actual and expected height did not differ between groups. Conclusion These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100100
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2018.07.015
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.96 n.1 2020
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
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