Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jped.2015.12.007 http://hdl.handle.net/11449/169007 |
Resumo: | Objective Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods This was a case–control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed. |
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Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantisLack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesityAKT1AKTIPChildhood obesityFat mass and obesity associatedGeneSingle-nucleotide polymorphismsObjective Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods This was a case–control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de Minas Gerais (UFMG) INCT de Medicina MolecularUniversidade de São Paulo (USP) Faculdade de Medicina de Ribeirão Preto (FMRP) Departamento de FarmacologiaUniversidade Federal de Juiz de Fora (UFJF) Instituto de Ciências Biológicas Departamento de FisiologiaUniversidade Estadual Paulista (UNESP)Universidade Estadual Paulista (UNESP)Universidade Federal de Minas Gerais (UFMG)Universidade de São Paulo (USP)Instituto de Ciências BiológicasUniversidade Estadual Paulista (Unesp)Pereira, Patrícia de AraújoAlvim-Soares, António MarcosSandrim, Valéria Cristina [UNESP]Lanna, Carla Márcia MoreiraSouza-Costa, Débora CristineBelo, Vanessa de Almeidade Paula, Jonas JardimTanus-Santos, José EduardoRomano-Silva, Marco AurélioMiranda, Débora Marques de2018-12-11T16:43:59Z2018-12-11T16:43:59Z2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article521-527application/pdfhttp://dx.doi.org/10.1016/j.jped.2015.12.007Jornal de Pediatria, v. 92, n. 5, p. 521-527, 2016.0021-7557http://hdl.handle.net/11449/16900710.1016/j.jped.2015.12.0072-s2.0-849908850042-s2.0-84990885004.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporJornal de Pediatria0,704info:eu-repo/semantics/openAccess2023-11-21T06:12:07Zoai:repositorio.unesp.br:11449/169007Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-21T06:12:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
spellingShingle |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis Pereira, Patrícia de Araújo AKT1 AKTIP Childhood obesity Fat mass and obesity associated Gene Single-nucleotide polymorphisms |
title_short |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
title_full |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
title_fullStr |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
title_full_unstemmed |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
title_sort |
Falta de associação entre o polimorfismo genético do FTO, AKT1 e AKTIP e o sobrepeso e a obesidade infantis |
author |
Pereira, Patrícia de Araújo |
author_facet |
Pereira, Patrícia de Araújo Alvim-Soares, António Marcos Sandrim, Valéria Cristina [UNESP] Lanna, Carla Márcia Moreira Souza-Costa, Débora Cristine Belo, Vanessa de Almeida de Paula, Jonas Jardim Tanus-Santos, José Eduardo Romano-Silva, Marco Aurélio Miranda, Débora Marques de |
author_role |
author |
author2 |
Alvim-Soares, António Marcos Sandrim, Valéria Cristina [UNESP] Lanna, Carla Márcia Moreira Souza-Costa, Débora Cristine Belo, Vanessa de Almeida de Paula, Jonas Jardim Tanus-Santos, José Eduardo Romano-Silva, Marco Aurélio Miranda, Débora Marques de |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Minas Gerais (UFMG) Universidade de São Paulo (USP) Instituto de Ciências Biológicas Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pereira, Patrícia de Araújo Alvim-Soares, António Marcos Sandrim, Valéria Cristina [UNESP] Lanna, Carla Márcia Moreira Souza-Costa, Débora Cristine Belo, Vanessa de Almeida de Paula, Jonas Jardim Tanus-Santos, José Eduardo Romano-Silva, Marco Aurélio Miranda, Débora Marques de |
dc.subject.por.fl_str_mv |
AKT1 AKTIP Childhood obesity Fat mass and obesity associated Gene Single-nucleotide polymorphisms |
topic |
AKT1 AKTIP Childhood obesity Fat mass and obesity associated Gene Single-nucleotide polymorphisms |
description |
Objective Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods This was a case–control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 2018-12-11T16:43:59Z 2018-12-11T16:43:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jped.2015.12.007 Jornal de Pediatria, v. 92, n. 5, p. 521-527, 2016. 0021-7557 http://hdl.handle.net/11449/169007 10.1016/j.jped.2015.12.007 2-s2.0-84990885004 2-s2.0-84990885004.pdf |
url |
http://dx.doi.org/10.1016/j.jped.2015.12.007 http://hdl.handle.net/11449/169007 |
identifier_str_mv |
Jornal de Pediatria, v. 92, n. 5, p. 521-527, 2016. 0021-7557 10.1016/j.jped.2015.12.007 2-s2.0-84990885004 2-s2.0-84990885004.pdf |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Jornal de Pediatria 0,704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
521-527 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1792961882131267584 |