Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202649 |
Resumo: | Currently, there is great interest in the study of water-soluble metal compounds capable of releasing carbon monoxide, due to their potential therapeutic use. This paper reports the synthesis, spectroscopic characteristics and CO release properties of three water-soluble manganese(I) carbonyl compounds [Mn(aaz)(CO)3]Br (1; where aaz = 6-amino-6-methylperhydro-1,4-diazepine), [Mn(Me2aaz)(CO)3]Br (2; where Me2aaz = 6-amino-1,4,6-trimethyl-1,4-diazacycloheptane) and [Mn(tacn)(CO)3]Br (3; where tacn = 1,4,7-triazacyclononane), that can act as photoCORMs (where CORM is carbon monoxide-releasing molecule). The main aim was to propose a mechanism for the CO release. Compounds 1-3 are capable of releasing carbon monoxide when exposed to light (λ385 and λ410) and thus, act as photoCORMs. The formation of a biscarbonyl intermediate was identified during the photo-release process at λ385 and the quantum yields and rates of CO release were determined. The proposed CO release mechanisms involve two steps, where photo and redox processes take place, and compounds 1 and 2 exhibit a slightly different mechanism from compound 3. A good understanding of the CO photo-release mechanism is very important with regard to the development of more efficient compounds, particularly those intended for medical applications. |
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Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release InvestigationphotoCORMmanganese(I) tricarbonyl compoundsphotoreactivityCurrently, there is great interest in the study of water-soluble metal compounds capable of releasing carbon monoxide, due to their potential therapeutic use. This paper reports the synthesis, spectroscopic characteristics and CO release properties of three water-soluble manganese(I) carbonyl compounds [Mn(aaz)(CO)3]Br (1; where aaz = 6-amino-6-methylperhydro-1,4-diazepine), [Mn(Me2aaz)(CO)3]Br (2; where Me2aaz = 6-amino-1,4,6-trimethyl-1,4-diazacycloheptane) and [Mn(tacn)(CO)3]Br (3; where tacn = 1,4,7-triazacyclononane), that can act as photoCORMs (where CORM is carbon monoxide-releasing molecule). The main aim was to propose a mechanism for the CO release. Compounds 1-3 are capable of releasing carbon monoxide when exposed to light (λ385 and λ410) and thus, act as photoCORMs. The formation of a biscarbonyl intermediate was identified during the photo-release process at λ385 and the quantum yields and rates of CO release were determined. The proposed CO release mechanisms involve two steps, where photo and redox processes take place, and compounds 1 and 2 exhibit a slightly different mechanism from compound 3. A good understanding of the CO photo-release mechanism is very important with regard to the development of more efficient compounds, particularly those intended for medical applications.Sociedade Brasileira de Química2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202649Journal of the Brazilian Chemical Society v.30 n.12 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190183info:eu-repo/semantics/openAccessWeiss,Vitor C.Amorim,André L.Xavier,Fernando R.Bortoluzzi,Adailton J.Neves,AdemirPeralta,Rosely A.eng2019-10-21T00:00:00Zoai:scielo:S0103-50532019001202649Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-10-21T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
title |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
spellingShingle |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation Weiss,Vitor C. photoCORM manganese(I) tricarbonyl compounds photoreactivity |
title_short |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
title_full |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
title_fullStr |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
title_full_unstemmed |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
title_sort |
Light Response of Three Water-Soluble MnI PhotoCORMs: Spectroscopic Features and CO Release Investigation |
author |
Weiss,Vitor C. |
author_facet |
Weiss,Vitor C. Amorim,André L. Xavier,Fernando R. Bortoluzzi,Adailton J. Neves,Ademir Peralta,Rosely A. |
author_role |
author |
author2 |
Amorim,André L. Xavier,Fernando R. Bortoluzzi,Adailton J. Neves,Ademir Peralta,Rosely A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Weiss,Vitor C. Amorim,André L. Xavier,Fernando R. Bortoluzzi,Adailton J. Neves,Ademir Peralta,Rosely A. |
dc.subject.por.fl_str_mv |
photoCORM manganese(I) tricarbonyl compounds photoreactivity |
topic |
photoCORM manganese(I) tricarbonyl compounds photoreactivity |
description |
Currently, there is great interest in the study of water-soluble metal compounds capable of releasing carbon monoxide, due to their potential therapeutic use. This paper reports the synthesis, spectroscopic characteristics and CO release properties of three water-soluble manganese(I) carbonyl compounds [Mn(aaz)(CO)3]Br (1; where aaz = 6-amino-6-methylperhydro-1,4-diazepine), [Mn(Me2aaz)(CO)3]Br (2; where Me2aaz = 6-amino-1,4,6-trimethyl-1,4-diazacycloheptane) and [Mn(tacn)(CO)3]Br (3; where tacn = 1,4,7-triazacyclononane), that can act as photoCORMs (where CORM is carbon monoxide-releasing molecule). The main aim was to propose a mechanism for the CO release. Compounds 1-3 are capable of releasing carbon monoxide when exposed to light (λ385 and λ410) and thus, act as photoCORMs. The formation of a biscarbonyl intermediate was identified during the photo-release process at λ385 and the quantum yields and rates of CO release were determined. The proposed CO release mechanisms involve two steps, where photo and redox processes take place, and compounds 1 and 2 exhibit a slightly different mechanism from compound 3. A good understanding of the CO photo-release mechanism is very important with regard to the development of more efficient compounds, particularly those intended for medical applications. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202649 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019001202649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190183 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.12 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318182514556928 |