Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics

Detalhes bibliográficos
Autor(a) principal: Alberto,Eduardo E
Data de Publicação: 2010
Outros Autores: Nascimento,Vanessa do, Braga,Antonio L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100004
Resumo: This review covers the past decade of intensive research on the design, synthesis and screening of organoselenides and tellurides as catalyst able to mimic the activity of the selenoenzyme glutathione peroxidase (GPx). This important enzyme forms part of the detoxification system in humans which deals with harmful peroxides and their byproducts formed during oxygen metabolism. Several strategies to enhance the GPx-like activity of compounds such as diselenides, selenides and tellurides have been proposed in recent years. Different mechanisms of action of these compounds are also presented in this review highlighting new advances in this exciting research field.
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spelling Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimeticsglutathione peroxidase (GPx)selenoenzymemimeticseleniumtelluriumselenidesThis review covers the past decade of intensive research on the design, synthesis and screening of organoselenides and tellurides as catalyst able to mimic the activity of the selenoenzyme glutathione peroxidase (GPx). This important enzyme forms part of the detoxification system in humans which deals with harmful peroxides and their byproducts formed during oxygen metabolism. Several strategies to enhance the GPx-like activity of compounds such as diselenides, selenides and tellurides have been proposed in recent years. Different mechanisms of action of these compounds are also presented in this review highlighting new advances in this exciting research field.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100004Journal of the Brazilian Chemical Society v.21 n.11 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010001100004info:eu-repo/semantics/openAccessAlberto,Eduardo ENascimento,Vanessa doBraga,Antonio Leng2010-12-15T00:00:00Zoai:scielo:S0103-50532010001100004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-12-15T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
title Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
spellingShingle Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
Alberto,Eduardo E
glutathione peroxidase (GPx)
selenoenzyme
mimetic
selenium
tellurium
selenides
title_short Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
title_full Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
title_fullStr Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
title_full_unstemmed Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
title_sort Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
author Alberto,Eduardo E
author_facet Alberto,Eduardo E
Nascimento,Vanessa do
Braga,Antonio L
author_role author
author2 Nascimento,Vanessa do
Braga,Antonio L
author2_role author
author
dc.contributor.author.fl_str_mv Alberto,Eduardo E
Nascimento,Vanessa do
Braga,Antonio L
dc.subject.por.fl_str_mv glutathione peroxidase (GPx)
selenoenzyme
mimetic
selenium
tellurium
selenides
topic glutathione peroxidase (GPx)
selenoenzyme
mimetic
selenium
tellurium
selenides
description This review covers the past decade of intensive research on the design, synthesis and screening of organoselenides and tellurides as catalyst able to mimic the activity of the selenoenzyme glutathione peroxidase (GPx). This important enzyme forms part of the detoxification system in humans which deals with harmful peroxides and their byproducts formed during oxygen metabolism. Several strategies to enhance the GPx-like activity of compounds such as diselenides, selenides and tellurides have been proposed in recent years. Different mechanisms of action of these compounds are also presented in this review highlighting new advances in this exciting research field.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010001100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.11 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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