New approaches to the development of anti-protozoan drug candidates: a review of patents

• Autor(a) principal: Cunha,Elaine F. F. da
• Data de Publicação: 2010
• Outros Autores: Ramalho,Teodorico C., Mancini,Daiana T., Fonseca,Emanuella M. B., Oliveira,Aline A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001000002
• topic: neglected disease; potential antiprotozoan compounds; patents

Protozoan infections are parasitic diseases that affect hundreds of millions of people worldwide, but have been largely neglected for drug development because they affect poor people in poor regions of the world. Most of the current drugs used to treat these diseases are decades old and have many limitations, including the emergence of drug resistance. This review will focus on the most recent developments, from 2001 to 2008, published in the field of patents and publications, paying particular attention to promising compounds acting against trypanosomiasis, leishmaniasis, malaria, toxoplasmosis, amebiasis, giardiasis, balantidiasis and pneumocystosis, their chemistry and biological evaluation, and to new chemical and pharmaceutical processes.