The chemistry of isatins: a review from 1975 to 1999

• Autor(a) principal: Silva,Joaquim F. M. da
• Data de Publicação: 2001
• Outros Autores: Garden,Simon J., Pinto,Angelo C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300002
• topic: isatin; heterocyclic synthesis; drug synthesis; metal complexes

Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.