Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance

Detalhes bibliográficos
Autor(a) principal: Samadhiya,Pushkal
Data de Publicação: 2012
Outros Autores: Sharma,Ritu, Srivastava,Santosh K., Srivastava,S. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010
Resumo: A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.
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spelling Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importancesynthesisazetidinonebiosignificanceA new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010Química Nova v.35 n.5 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000500010info:eu-repo/semantics/openAccessSamadhiya,PushkalSharma,RituSrivastava,Santosh K.Srivastava,S. D.eng2012-07-02T00:00:00Zoai:scielo:S0100-40422012000500010Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-07-02T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
title Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
spellingShingle Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
Samadhiya,Pushkal
synthesis
azetidinone
biosignificance
title_short Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
title_full Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
title_fullStr Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
title_full_unstemmed Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
title_sort Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance
author Samadhiya,Pushkal
author_facet Samadhiya,Pushkal
Sharma,Ritu
Srivastava,Santosh K.
Srivastava,S. D.
author_role author
author2 Sharma,Ritu
Srivastava,Santosh K.
Srivastava,S. D.
author2_role author
author
author
dc.contributor.author.fl_str_mv Samadhiya,Pushkal
Sharma,Ritu
Srivastava,Santosh K.
Srivastava,S. D.
dc.subject.por.fl_str_mv synthesis
azetidinone
biosignificance
topic synthesis
azetidinone
biosignificance
description A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, ¹H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000500010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000500010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.5 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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