Solution thermodynamics of methocarbamol in some ethanol + water mixtures

Detalhes bibliográficos
Autor(a) principal: Mercado,Katia C.
Data de Publicação: 2012
Outros Autores: Rodríguez,Gerson A., Delgado,Daniel R., Martínez,Fleming, Romdhani,Asma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001000015
Resumo: Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric values of drug fusion. The drug solubility was greatest in the mixtures with 0.70 or 0.80 mass fraction of ethanol and lowest in neat water across all temperatures studied. Non-linear enthalpy-entropy compensation was found for the dissolution processes. Accordingly, solution enthalpy drives the respective processes in almost all the solvent systems analyzed.
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spelling Solution thermodynamics of methocarbamol in some ethanol + water mixturescosolvencymethocarbamolsolubilityApparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric values of drug fusion. The drug solubility was greatest in the mixtures with 0.70 or 0.80 mass fraction of ethanol and lowest in neat water across all temperatures studied. Non-linear enthalpy-entropy compensation was found for the dissolution processes. Accordingly, solution enthalpy drives the respective processes in almost all the solvent systems analyzed.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001000015Química Nova v.35 n.10 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012001000015info:eu-repo/semantics/openAccessMercado,Katia C.Rodríguez,Gerson A.Delgado,Daniel R.Martínez,FlemingRomdhani,Asmaeng2021-02-11T00:00:00Zoai:scielo:S0100-40422012001000015Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2021-02-11T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Solution thermodynamics of methocarbamol in some ethanol + water mixtures
title Solution thermodynamics of methocarbamol in some ethanol + water mixtures
spellingShingle Solution thermodynamics of methocarbamol in some ethanol + water mixtures
Mercado,Katia C.
cosolvency
methocarbamol
solubility
title_short Solution thermodynamics of methocarbamol in some ethanol + water mixtures
title_full Solution thermodynamics of methocarbamol in some ethanol + water mixtures
title_fullStr Solution thermodynamics of methocarbamol in some ethanol + water mixtures
title_full_unstemmed Solution thermodynamics of methocarbamol in some ethanol + water mixtures
title_sort Solution thermodynamics of methocarbamol in some ethanol + water mixtures
author Mercado,Katia C.
author_facet Mercado,Katia C.
Rodríguez,Gerson A.
Delgado,Daniel R.
Martínez,Fleming
Romdhani,Asma
author_role author
author2 Rodríguez,Gerson A.
Delgado,Daniel R.
Martínez,Fleming
Romdhani,Asma
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mercado,Katia C.
Rodríguez,Gerson A.
Delgado,Daniel R.
Martínez,Fleming
Romdhani,Asma
dc.subject.por.fl_str_mv cosolvency
methocarbamol
solubility
topic cosolvency
methocarbamol
solubility
description Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric values of drug fusion. The drug solubility was greatest in the mixtures with 0.70 or 0.80 mass fraction of ethanol and lowest in neat water across all temperatures studied. Non-linear enthalpy-entropy compensation was found for the dissolution processes. Accordingly, solution enthalpy drives the respective processes in almost all the solvent systems analyzed.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001000015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001000015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012001000015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.10 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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