Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

Detalhes bibliográficos
Autor(a) principal: Delgado,Daniel R.
Data de Publicação: 2010
Outros Autores: Ruidiaz,Miller A., Gómez,Sandra M., Gantiva,Mauricio, Martínez,Fleming
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900019
Resumo: By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.
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spelling Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixturescosolvencysodium naproxensolubilityBy using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900019Química Nova v.33 n.9 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000900019info:eu-repo/semantics/openAccessDelgado,Daniel R.Ruidiaz,Miller A.Gómez,Sandra M.Gantiva,MauricioMartínez,Flemingeng2011-01-13T00:00:00Zoai:scielo:S0100-40422010000900019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-01-13T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
title Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
spellingShingle Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
Delgado,Daniel R.
cosolvency
sodium naproxen
solubility
title_short Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
title_full Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
title_fullStr Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
title_full_unstemmed Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
title_sort Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures
author Delgado,Daniel R.
author_facet Delgado,Daniel R.
Ruidiaz,Miller A.
Gómez,Sandra M.
Gantiva,Mauricio
Martínez,Fleming
author_role author
author2 Ruidiaz,Miller A.
Gómez,Sandra M.
Gantiva,Mauricio
Martínez,Fleming
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Delgado,Daniel R.
Ruidiaz,Miller A.
Gómez,Sandra M.
Gantiva,Mauricio
Martínez,Fleming
dc.subject.por.fl_str_mv cosolvency
sodium naproxen
solubility
topic cosolvency
sodium naproxen
solubility
description By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000900019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.9 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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