Assessment of cardiovascular risk in patients with rheumatoid arthritis using the SCORE risk index

• Main Author: Campos,Otávio Augusto Martins de
• Publication Date: 2016
• Other Authors: Nazário,Nazaré Otília, Fialho,Sônia Cristina de Magalhães Souza, Fialho,Guilherme Loureiro, Oliveira,Fernando José Savóia de, Castro,Gláucio Ricardo Werner de, Pereira,Ivânio Alves
• Format: Article
• Language: eng
• Source: Revista Brasileira de Reumatologia (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000200138
• topic: Rheumatoid arthritis; Cardiovascular events; Cardiovascular risk; Risk factors

ABSTRACT Introduction: Rheumatoid arthritis is an autoimmune disease that causes systemic involvement and is associated with increased risk of cardiovascular disease. Objective: To analyze the prediction index of 10-year risk of a fatal cardiovascular disease event in female RA patients versus controls. Methods: Case-control study with analysis of 100 female patients matched for age and gender versus 100 patients in the control group. For the prediction of 10-year risk of a fatal cardiovascular disease event, the SCORE and modified SCORE (mSCORE) risk indexes were used, as suggested by EULAR, in the subgroup with two or more of the following: duration of disease ≥10 years, RF and/or anti-CCP positivity, and extra-articular manifestations. Results: The prevalence of analyzed comorbidities was similar in RA patients compared with the control group (p > 0.05). The means of the SCORE risk index in RA patients and in the control group were 1.99 (SD: 1.89) and 1.56 (SD: 1.87) (p = 0.06), respectively. The means of mSCORE index in RA patients and in the control group were 2.84 (SD = 2.86) and 1.56 (SD = 1.87) (p = 0.001), respectively. By using the SCORE risk index, 11% of RA patients were classified as of high risk, and with the use of mSCORE risk index, 36% were at high risk (p< 0.001). Conclusion: The SCORE risk index is similar in both groups, but with the application of the mSCORE index, we recognized that RA patients have a higher 10-year risk of a fatal cardiovascular disease event, and this reinforces the importance of factors inherent to the disease not measured in the SCORE risk index, but considered in mSCORE risk index.