Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Reumatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600490 |
Resumo: | ABSTRACT Introduction: Intra-articular injection of corticosteroids (IIC) for treatment of patients with juvenile idiopathic arthritis (JIA) is increasingly used in Pediatric Rheumatology. Objectives: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit. Methods: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months. Results: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p = 0.037) and the occurrence of uveitis in the course of the disease (p = 0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p = 0.001), lesser values stated in the overall visual analog scale by the physician (p = 0.015) and by parents/patient (p = 0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed. Conclusion: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure. |
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Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good responseIntra-articular injectionJuvenile idiopathic arthritisTriamcinolone hexacetonideTreatment and uveitisABSTRACT Introduction: Intra-articular injection of corticosteroids (IIC) for treatment of patients with juvenile idiopathic arthritis (JIA) is increasingly used in Pediatric Rheumatology. Objectives: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit. Methods: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months. Results: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p = 0.037) and the occurrence of uveitis in the course of the disease (p = 0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p = 0.001), lesser values stated in the overall visual analog scale by the physician (p = 0.015) and by parents/patient (p = 0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed. Conclusion: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure.Sociedade Brasileira de Reumatologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600490Revista Brasileira de Reumatologia v.56 n.6 2016reponame:Revista Brasileira de Reumatologia (Online)instname:Sociedade Brasileira de Reumatologia (SBR)instacron:SBR10.1016/j.rbre.2016.01.001info:eu-repo/semantics/openAccessCunha,Ana Luiza GarciaSilva,Vanessa Bugni Miotto eOsaku,Fabiane MitieNiemxeski,Luísa BrasilFurtado,Rita Nely VilarNatour,JamilTerreri,Maria Teresa de Sande e Lemos Ramos Ascensãoeng2016-12-15T00:00:00Zoai:scielo:S0482-50042016000600490Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0482-5004&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.php||sbre@terra.com.br1809-45700482-5004opendoar:2016-12-15T00:00Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR)false |
dc.title.none.fl_str_mv |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
title |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
spellingShingle |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response Cunha,Ana Luiza Garcia Intra-articular injection Juvenile idiopathic arthritis Triamcinolone hexacetonide Treatment and uveitis |
title_short |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
title_full |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
title_fullStr |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
title_full_unstemmed |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
title_sort |
Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response |
author |
Cunha,Ana Luiza Garcia |
author_facet |
Cunha,Ana Luiza Garcia Silva,Vanessa Bugni Miotto e Osaku,Fabiane Mitie Niemxeski,Luísa Brasil Furtado,Rita Nely Vilar Natour,Jamil Terreri,Maria Teresa de Sande e Lemos Ramos Ascensão |
author_role |
author |
author2 |
Silva,Vanessa Bugni Miotto e Osaku,Fabiane Mitie Niemxeski,Luísa Brasil Furtado,Rita Nely Vilar Natour,Jamil Terreri,Maria Teresa de Sande e Lemos Ramos Ascensão |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cunha,Ana Luiza Garcia Silva,Vanessa Bugni Miotto e Osaku,Fabiane Mitie Niemxeski,Luísa Brasil Furtado,Rita Nely Vilar Natour,Jamil Terreri,Maria Teresa de Sande e Lemos Ramos Ascensão |
dc.subject.por.fl_str_mv |
Intra-articular injection Juvenile idiopathic arthritis Triamcinolone hexacetonide Treatment and uveitis |
topic |
Intra-articular injection Juvenile idiopathic arthritis Triamcinolone hexacetonide Treatment and uveitis |
description |
ABSTRACT Introduction: Intra-articular injection of corticosteroids (IIC) for treatment of patients with juvenile idiopathic arthritis (JIA) is increasingly used in Pediatric Rheumatology. Objectives: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit. Methods: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months. Results: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p = 0.037) and the occurrence of uveitis in the course of the disease (p = 0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p = 0.001), lesser values stated in the overall visual analog scale by the physician (p = 0.015) and by parents/patient (p = 0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed. Conclusion: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600490 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000600490 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rbre.2016.01.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Reumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Reumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Reumatologia v.56 n.6 2016 reponame:Revista Brasileira de Reumatologia (Online) instname:Sociedade Brasileira de Reumatologia (SBR) instacron:SBR |
instname_str |
Sociedade Brasileira de Reumatologia (SBR) |
instacron_str |
SBR |
institution |
SBR |
reponame_str |
Revista Brasileira de Reumatologia (Online) |
collection |
Revista Brasileira de Reumatologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR) |
repository.mail.fl_str_mv |
||sbre@terra.com.br |
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1750318051476111360 |