Percutaneous absorption enhancers: mechanisms and potential
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000700006 |
Resumo: | Transdermal applications of drugs present many advantages in terms of absorption, however this is not easily obtained through the transdermal route. The principle barrier is the stratum corneum and one of the strategies that have been found to promote cutaneous drug penetration is through the use of absorption enhancers. Many substances have been identified as absorption enhancers. Although the list of substances that promote absorption is growing, in most cases, there is a direct correlation between the effects of absorption enhancers and their skin toxicity. The use of these substances depends therefore on studies which focus on local and systemic toxicity, as well as action mechanisms. |
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Percutaneous absorption enhancers: mechanisms and potentialAbsorption enhancerscutaneous penetrationpercutaneous absorptionTransdermal applications of drugs present many advantages in terms of absorption, however this is not easily obtained through the transdermal route. The principle barrier is the stratum corneum and one of the strategies that have been found to promote cutaneous drug penetration is through the use of absorption enhancers. Many substances have been identified as absorption enhancers. Although the list of substances that promote absorption is growing, in most cases, there is a direct correlation between the effects of absorption enhancers and their skin toxicity. The use of these substances depends therefore on studies which focus on local and systemic toxicity, as well as action mechanisms.Instituto de Tecnologia do Paraná - Tecpar2007-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000700006Brazilian Archives of Biology and Technology v.50 n.6 2007reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132007000700006info:eu-repo/semantics/openAccessCarpentieri-Rodrigues,Letícia NormaZanluchi,Juliana ModoloGrebogi,Ivanna Hinkeeng2008-03-03T00:00:00Zoai:scielo:S1516-89132007000700006Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2008-03-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Percutaneous absorption enhancers: mechanisms and potential |
title |
Percutaneous absorption enhancers: mechanisms and potential |
spellingShingle |
Percutaneous absorption enhancers: mechanisms and potential Carpentieri-Rodrigues,Letícia Norma Absorption enhancers cutaneous penetration percutaneous absorption |
title_short |
Percutaneous absorption enhancers: mechanisms and potential |
title_full |
Percutaneous absorption enhancers: mechanisms and potential |
title_fullStr |
Percutaneous absorption enhancers: mechanisms and potential |
title_full_unstemmed |
Percutaneous absorption enhancers: mechanisms and potential |
title_sort |
Percutaneous absorption enhancers: mechanisms and potential |
author |
Carpentieri-Rodrigues,Letícia Norma |
author_facet |
Carpentieri-Rodrigues,Letícia Norma Zanluchi,Juliana Modolo Grebogi,Ivanna Hinke |
author_role |
author |
author2 |
Zanluchi,Juliana Modolo Grebogi,Ivanna Hinke |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carpentieri-Rodrigues,Letícia Norma Zanluchi,Juliana Modolo Grebogi,Ivanna Hinke |
dc.subject.por.fl_str_mv |
Absorption enhancers cutaneous penetration percutaneous absorption |
topic |
Absorption enhancers cutaneous penetration percutaneous absorption |
description |
Transdermal applications of drugs present many advantages in terms of absorption, however this is not easily obtained through the transdermal route. The principle barrier is the stratum corneum and one of the strategies that have been found to promote cutaneous drug penetration is through the use of absorption enhancers. Many substances have been identified as absorption enhancers. Although the list of substances that promote absorption is growing, in most cases, there is a direct correlation between the effects of absorption enhancers and their skin toxicity. The use of these substances depends therefore on studies which focus on local and systemic toxicity, as well as action mechanisms. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000700006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000700006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132007000700006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.50 n.6 2007 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318271882592256 |