Continuous infusion of propofol at variable rates in a time dependent in cats

Detalhes bibliográficos
Autor(a) principal: Comassetto, Felipe
Data de Publicação: 2015
Outros Autores: Gehrcke, Martielo Ivan, Lima, Marcos Paulo Antunes de, Tocheto, Ronise, Oleskovicz, Nilson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16479
Resumo: Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats. Sixteen healthy female cats undergoing elective ovariohysterectomy and received as premedication dexmedetomidine (2.5 ?g/kg), methadone (0.5 mg/kg) and ketamine (0.5 mg/kg) administrated at intramuscular rote. After 15 minutes , the animals were allocated into two groups : Fixed Rate (GFR), which received propofol 4mg/kg, followed by continuous infusion (CI ) at the rate of 0.3 mg/kg/min for 60 minutes; and Variable Rate (GVR) receiving the same induction protocol exchange with the IC starting at 0.3 mg/ kg/min for 10 minutes, 0.25 mg/kg/min up to 25 minutes, 0.2 mg/ kg/min up to 45 minutes and 0.15 mg/kg /min to 60 min of infusion based on simulation STAMPUMP®. We evaluated the cardiac frequency (HR), respiratory rate (RR), systolic blood pressure (SBP) and maintenance of anesthesia during 60 minutes of infusion , as well as time to extubation, sternal recumbency and to full recovery. We observed similar anesthesia in both groups, but the GVR was used propofol least 30% for maintenance anesthesia. There was a reduction of HR and f in both groups after induction, with one animal the GFR developed apnea during all periods evaluated . Decreased SBP in GFR at all times in relation to the baseline, as the GVR, SBP decreased in just a moment. There was no significant difference between groups with respect to time to extubation (GFR 43.2 ± 19.5 min and 30.7 ± 13.2 min GVR) , deambulation ( GFR 60.7 ± 29.6 min and 41.6 ± GVR 17.2 min ) and total recovery (GFR 136 ± 34.3 min and 101.5 ± 29.6 min GVR) . We conclude that the two techniques keeps similar anesthetic plans, being safe for use in cats, and that the rate has varied propofol consumption 30 % lower.
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spelling Continuous infusion of propofol at variable rates in a time dependent in catsInfusão contínua de propofol à taxa variada tempo dependente em gatosTotal intravenous anesthesiaPharmacokineticsContinuous infusionFelines.Anestesia total intravenosaFarmacocinéticaInfusão contínuaFelinos.5.05.01.01-1Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats. Sixteen healthy female cats undergoing elective ovariohysterectomy and received as premedication dexmedetomidine (2.5 ?g/kg), methadone (0.5 mg/kg) and ketamine (0.5 mg/kg) administrated at intramuscular rote. After 15 minutes , the animals were allocated into two groups : Fixed Rate (GFR), which received propofol 4mg/kg, followed by continuous infusion (CI ) at the rate of 0.3 mg/kg/min for 60 minutes; and Variable Rate (GVR) receiving the same induction protocol exchange with the IC starting at 0.3 mg/ kg/min for 10 minutes, 0.25 mg/kg/min up to 25 minutes, 0.2 mg/ kg/min up to 45 minutes and 0.15 mg/kg /min to 60 min of infusion based on simulation STAMPUMP®. We evaluated the cardiac frequency (HR), respiratory rate (RR), systolic blood pressure (SBP) and maintenance of anesthesia during 60 minutes of infusion , as well as time to extubation, sternal recumbency and to full recovery. We observed similar anesthesia in both groups, but the GVR was used propofol least 30% for maintenance anesthesia. There was a reduction of HR and f in both groups after induction, with one animal the GFR developed apnea during all periods evaluated . Decreased SBP in GFR at all times in relation to the baseline, as the GVR, SBP decreased in just a moment. There was no significant difference between groups with respect to time to extubation (GFR 43.2 ± 19.5 min and 30.7 ± 13.2 min GVR) , deambulation ( GFR 60.7 ± 29.6 min and 41.6 ± GVR 17.2 min ) and total recovery (GFR 136 ± 34.3 min and 101.5 ± 29.6 min GVR) . We conclude that the two techniques keeps similar anesthetic plans, being safe for use in cats, and that the rate has varied propofol consumption 30 % lower.Os felinos biotransformam o propofol lentamente, desenvolvendo efeito cumulativo. Neste sentido, objetivou-se desenvolver um esquema de infusão contínua de propofol a taxa variada tempo dependente em gatos. Foram utilizadas 16 gatas hígidas as quais foram submetidas à ovariossalpingohisterectomia eletiva e receberam como medicação pré-anestésica (MPA) dexmedetomidina (2,5?g/kg), metadona (0,5mg/kg) e cetamina (0,5mg/kg) por via intramuscular. Após 15 minutos, os animais foram alocados em dois grupos: Taxa Fixa (GTF), que receberam propofol 4mg/kg, seguido de infusão contínua (IC) na taxa de 0,3mg/kg/min durante 60 minutos; e Taxa Variada (GTV) que receberam o mesmo protocolo de indução com as taxas de IC iniciando em 0,3mg/kg/min durante 10 minutos, 0,25mg/kg/min até 25 minutos, 0,2 mg/kg/min até 45 minutos e 0,15mg/kg/min até 60 minutos de infusão baseado no software de simulação STAMPUMP®. Avaliaram-se as frequências cardíaca (FC) e respiratória (f), pressão arterial sistólica (PAS) e a manutenção do plano anestésico durante 60 minutos de infusão, bem como, os tempos para extubação, para decúbito esternal e de recuperação total. Observou-se plano anestésico similar em ambos os grupos, porém no GTV utilizou-se 30% menos propofol para manutenção da anestesia. Houve redução da FC e f em ambos os grupos após a indução, sendo que um animal do GTF apresentou apnéia durante todos os momentos avaliados. Houve diminuição da PAS no GTF em todos os momentos em relação ao basal, já no GTV, a PAS diminuiu apenas em um momento. Não houve diferença significativa entre os grupos em relação aos tempos para extubação (GTF 43,2±19,5min e GTV 30,7±13,2min), para deambulação (GTF 60,7±29,6min e GTV 41,6±17,2min) e para recuperação total (GTF 136±34,3min e GTV 101,5±29,6min). Conclui-se que as duas técnicas mantém planos anestésicos similares, sendo seguras para utilização em gatas, e que a taxa variada apresenta consumo de propofol 30% menor.UEL2015-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEstudo clínicoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/1647910.5433/1679-0359.2015v36n2p797Semina: Ciências Agrárias; Vol. 36 No. 2 (2015); 797-806Semina: Ciências Agrárias; v. 36 n. 2 (2015); 797-8061679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELporhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16479/pdf_654Copyright (c) 2015 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessComassetto, FelipeGehrcke, Martielo IvanLima, Marcos Paulo Antunes deTocheto, RoniseOleskovicz, Nilson2023-01-13T13:57:54Zoai:ojs.pkp.sfu.ca:article/16479Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2023-01-13T13:57:54Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Continuous infusion of propofol at variable rates in a time dependent in cats
Infusão contínua de propofol à taxa variada tempo dependente em gatos
title Continuous infusion of propofol at variable rates in a time dependent in cats
spellingShingle Continuous infusion of propofol at variable rates in a time dependent in cats
Comassetto, Felipe
Total intravenous anesthesia
Pharmacokinetics
Continuous infusion
Felines.
Anestesia total intravenosa
Farmacocinética
Infusão contínua
Felinos.
5.05.01.01-1
title_short Continuous infusion of propofol at variable rates in a time dependent in cats
title_full Continuous infusion of propofol at variable rates in a time dependent in cats
title_fullStr Continuous infusion of propofol at variable rates in a time dependent in cats
title_full_unstemmed Continuous infusion of propofol at variable rates in a time dependent in cats
title_sort Continuous infusion of propofol at variable rates in a time dependent in cats
author Comassetto, Felipe
author_facet Comassetto, Felipe
Gehrcke, Martielo Ivan
Lima, Marcos Paulo Antunes de
Tocheto, Ronise
Oleskovicz, Nilson
author_role author
author2 Gehrcke, Martielo Ivan
Lima, Marcos Paulo Antunes de
Tocheto, Ronise
Oleskovicz, Nilson
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Comassetto, Felipe
Gehrcke, Martielo Ivan
Lima, Marcos Paulo Antunes de
Tocheto, Ronise
Oleskovicz, Nilson
dc.subject.por.fl_str_mv Total intravenous anesthesia
Pharmacokinetics
Continuous infusion
Felines.
Anestesia total intravenosa
Farmacocinética
Infusão contínua
Felinos.
5.05.01.01-1
topic Total intravenous anesthesia
Pharmacokinetics
Continuous infusion
Felines.
Anestesia total intravenosa
Farmacocinética
Infusão contínua
Felinos.
5.05.01.01-1
description Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats. Sixteen healthy female cats undergoing elective ovariohysterectomy and received as premedication dexmedetomidine (2.5 ?g/kg), methadone (0.5 mg/kg) and ketamine (0.5 mg/kg) administrated at intramuscular rote. After 15 minutes , the animals were allocated into two groups : Fixed Rate (GFR), which received propofol 4mg/kg, followed by continuous infusion (CI ) at the rate of 0.3 mg/kg/min for 60 minutes; and Variable Rate (GVR) receiving the same induction protocol exchange with the IC starting at 0.3 mg/ kg/min for 10 minutes, 0.25 mg/kg/min up to 25 minutes, 0.2 mg/ kg/min up to 45 minutes and 0.15 mg/kg /min to 60 min of infusion based on simulation STAMPUMP®. We evaluated the cardiac frequency (HR), respiratory rate (RR), systolic blood pressure (SBP) and maintenance of anesthesia during 60 minutes of infusion , as well as time to extubation, sternal recumbency and to full recovery. We observed similar anesthesia in both groups, but the GVR was used propofol least 30% for maintenance anesthesia. There was a reduction of HR and f in both groups after induction, with one animal the GFR developed apnea during all periods evaluated . Decreased SBP in GFR at all times in relation to the baseline, as the GVR, SBP decreased in just a moment. There was no significant difference between groups with respect to time to extubation (GFR 43.2 ± 19.5 min and 30.7 ± 13.2 min GVR) , deambulation ( GFR 60.7 ± 29.6 min and 41.6 ± GVR 17.2 min ) and total recovery (GFR 136 ± 34.3 min and 101.5 ± 29.6 min GVR) . We conclude that the two techniques keeps similar anesthetic plans, being safe for use in cats, and that the rate has varied propofol consumption 30 % lower.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Estudo clínico
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16479
10.5433/1679-0359.2015v36n2p797
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16479
identifier_str_mv 10.5433/1679-0359.2015v36n2p797
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/16479/pdf_654
dc.rights.driver.fl_str_mv Copyright (c) 2015 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 36 No. 2 (2015); 797-806
Semina: Ciências Agrárias; v. 36 n. 2 (2015); 797-806
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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