Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/18349 |
Resumo: | Corynebacteria are part of the commensal microbiota of humans and animals, and their isolation from clinical samples has been neglected by clinicians, since those microorganisms is usually considered as contaminants. The present study was conducted in a tertiary hospital in the city of Rio de Janeiro, and clinical strains of Corynebacterium spp. and other Gram positive bacilli of clinical importance, isolated from a total of 548 blood cultures of hospitalized patients in several hospital sections, from February to December 2015. The following species were characterized by the use of MALDI-TOF (Matrix Assisted laser Desorption Ionization – Time of Flight): Corynebacterium striatum (n=07), Corynebacterium amycolatum (n=03), Corynebacterium aurimucosum (n=01), Corynebacterium minutissimum (n=01), Brevibacterium ravespurgense (n=1), Dietzia maris (n=01), Listeria monocytogenes (n=02), Tsukamurella paurometabola (n=01). The dissemination of C. striatum was investigated using a Pulsed-field gel electrophoresis (PFGE) technique demonstrating the prevalence of a single clone named pulsotype IC, related to strains previously isolated in a hospital from Rio de Janeiro. C. striatum and C. amycolatum strains were resistant to multiple antimicrobials, and among the 24 antimicrobials tested, the C. striatum samples showed sensitivity only to vancomycin, linezolid and tetracycline. Both C. striatum and C. amycolatum strains produced biofilm at abiotic hydrophobic and hydrophilic surfaces. In addition, the strains were capable to adhere, survive and persist within type II pneumocytes (A549). In view of in vivo models, these pathogens were able to cause hematological changes in mice, as well as to promote mechanisms of pathogenicity and lethality to Caenorhabditis elegans helminth. These features corroborate the pathogenicity of C. striatum and C. amycolatum and their knowledge may support the development of strategies for the prevention, monitoring and control of infections by these agents in nosocomial environment. Thus, C. striatum and C. amycolatum should be considered as potential risk factors for hematogenous infections in hospitalized patients and surveillance measures should be taken to avoid preventing, monitoring and controlling such infections in nosocomial setting. Further studies on these and other virulence attributes and their relevance to the pathogenesis of corynebacteria remain necessary to minimize the involvement of these pathogens as etiological agents . |
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Hirata Júnior, Raphaelhttp://lattes.cnpq.br/4484092525465200Guaraldi, Ana Luiza Mattoshttp://lattes.cnpq.br/8091118564093203Ignacio, Ana Claudia de Paula Rosahttp://lattes.cnpq.br/7809403473011306Sant’Anna, Louisy Sanches dos Santoshttp://lattes.cnpq.br/5999066009401057Napoleão, Fátimahttp://lattes.cnpq.br/6368074603262304Martins, Carlos Alberto de Souzahttp://lattes.cnpq.br/6457141178252146http://lattes.cnpq.br/8322495800228245Silva, Eliane Cristine daelianecsilva@uol.com.br2022-09-09T14:15:22Z2018-06-07SILVA, Eliane Cristine da. Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro. 2018. 135 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2018.http://www.bdtd.uerj.br/handle/1/18349Corynebacteria are part of the commensal microbiota of humans and animals, and their isolation from clinical samples has been neglected by clinicians, since those microorganisms is usually considered as contaminants. The present study was conducted in a tertiary hospital in the city of Rio de Janeiro, and clinical strains of Corynebacterium spp. and other Gram positive bacilli of clinical importance, isolated from a total of 548 blood cultures of hospitalized patients in several hospital sections, from February to December 2015. The following species were characterized by the use of MALDI-TOF (Matrix Assisted laser Desorption Ionization – Time of Flight): Corynebacterium striatum (n=07), Corynebacterium amycolatum (n=03), Corynebacterium aurimucosum (n=01), Corynebacterium minutissimum (n=01), Brevibacterium ravespurgense (n=1), Dietzia maris (n=01), Listeria monocytogenes (n=02), Tsukamurella paurometabola (n=01). The dissemination of C. striatum was investigated using a Pulsed-field gel electrophoresis (PFGE) technique demonstrating the prevalence of a single clone named pulsotype IC, related to strains previously isolated in a hospital from Rio de Janeiro. C. striatum and C. amycolatum strains were resistant to multiple antimicrobials, and among the 24 antimicrobials tested, the C. striatum samples showed sensitivity only to vancomycin, linezolid and tetracycline. Both C. striatum and C. amycolatum strains produced biofilm at abiotic hydrophobic and hydrophilic surfaces. In addition, the strains were capable to adhere, survive and persist within type II pneumocytes (A549). In view of in vivo models, these pathogens were able to cause hematological changes in mice, as well as to promote mechanisms of pathogenicity and lethality to Caenorhabditis elegans helminth. These features corroborate the pathogenicity of C. striatum and C. amycolatum and their knowledge may support the development of strategies for the prevention, monitoring and control of infections by these agents in nosocomial environment. Thus, C. striatum and C. amycolatum should be considered as potential risk factors for hematogenous infections in hospitalized patients and surveillance measures should be taken to avoid preventing, monitoring and controlling such infections in nosocomial setting. Further studies on these and other virulence attributes and their relevance to the pathogenesis of corynebacteria remain necessary to minimize the involvement of these pathogens as etiological agents .Pelo fato das corinebactérias constituírem parte da microbiota comensal de seres humanos e animais, o seu isolamento a partir de amostras clínicas tem sido negligenciado por profissionais de saúde sendo considerados como contaminantes. O presente estudo desenvolvido em um hospital terciário da cidade do Rio de Janeiro, avaliou amostras de Corynebacterium spp. e outros bacilos Gram positivos de importância clínica, isolados de 548 hemoculturas de pacientes internados em diversos setores, no período de fevereiro a dezembro de 2015. Foram identificadas através do MALDI-TOF (Matrix Assisted laser Desorption Ionization – Time of Flight) as seguintes espécies: Corynebacterium striatum (n=07), Corynebacterium amycolatum (n=03), Corynebacterium aurimucosum (n=01), Corynebacterium minutissimum (n=01), Brevibacterium ravespurgense (n=01), Dietzia maris (n=01), Listeria monocytogenes (n=2), Tsukamurella paurometabola (n=01). A disseminação de C. striatum foi investigada utilizando-se a técnica de eletroforese de campo pulsado (PFGE) demonstrando a prevalência de um único pulsotipo designado como IC devido à similaridade observada com amostras isoladas anteriormente em um hospital universitário do Rio de Janeiro. As amostras de C. striatum e C. amycolatum foram resistentes a múltiplos antimicrobianos, sendo que as amostras de C. striatum apresentaram sensibilidade somente à vancomicina, linezolida e tetraciclina, dentre os 24 antimicrobianos testados. Todas as amostras de C. striatum e C. amycolatum foram capazes de produzir biofilme sobre substratos abióticos hidrofílicos e hidrofóbicos e demonstraram a capacidade de aderir, sobreviver e persistir no interior de células epiteliais humanas (A549) em níveis variados. Adicionalmente, nos ensaios com modelos in vivo, C. striatum e C. amycolatum foram capazes de promover leucocitose, linfocitose, neutrofilia e monocitose absolutas em camundongos, assim como de promover mecanismos de patogenicidade e letalidade para o helminto Caenorhabditis elegans. Tais atributos corroboram para a patogenicidade de C. striatum e C. amycolatum e podem subsidiar o desenvolvimento de estratégias para a prevenção, monitoramento e o controle das infecções por estes agentes. Desta forma, C. striatum e C. amycolatum devem ser considerados riscos potenciais para pacientes hospitalizados e medidas de vigilância devem ser tomadas para prevenir, monitorar e controlar tais infecções nos ambientes nosocomiais. Estudos adicionais acerca desses e de outros atributos de virulência e da sua relevância para a patogenia de corinebactérias permanecem necessários, na tentativa de minimizar o envolvimento destes patógenos como agentes etiológicos de infecções relacionadas à assistência à saúde (IRAS).Submitted by Heloísa CB/A (helobdtd@gmail.com) on 2022-09-09T14:15:22Z No. of bitstreams: 1 Eliane Cristine da Silva.pdf: 4725219 bytes, checksum: 509977a5f58831667051d744f6376fa7 (MD5)Made available in DSpace on 2022-09-09T14:15:22Z (GMT). No. of bitstreams: 1 Eliane Cristine da Silva.pdf: 4725219 bytes, checksum: 509977a5f58831667051d744f6376fa7 (MD5) Previous issue date: 2018-06-07application/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em MicrobiologiaUERJBrasilCentro Biomédico::Faculdade de Ciências MédicasCorynebacterium striatumCorynebacterium amycolatumBlood cultureCorynebacterium striatumCorynebacterium amycolatumHemoculturaCIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADA::MICROBIOLOGIA MEDICACaracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de JaneiroCharacterization of clinical-epidemiological and microbiological aspects of Corynebacterium spp. isolated from hematogenous infections of patients attended at a tertiary hospital in the metropolitan region of Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALTese - Eliane Cristine da Silva - 2018 - CompletaTese - Eliane Cristine da Silva - 2018 - Completaapplication/pdf4725219http://www.bdtd.uerj.br/bitstream/1/18349/2/Tese+-+Eliane+Cristine+da+Silva+-+2018+-+Completa509977a5f58831667051d744f6376fa7MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/18349/1/license.txte5502652da718045d7fcd832b79fca29MD511/183492024-02-26 15:59:48.963oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-26T18:59:48Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
dc.title.alternative.eng.fl_str_mv |
Characterization of clinical-epidemiological and microbiological aspects of Corynebacterium spp. isolated from hematogenous infections of patients attended at a tertiary hospital in the metropolitan region of Rio de Janeiro |
title |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
spellingShingle |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro Silva, Eliane Cristine da Corynebacterium striatum Corynebacterium amycolatum Blood culture Corynebacterium striatum Corynebacterium amycolatum Hemocultura CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADA::MICROBIOLOGIA MEDICA |
title_short |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
title_full |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
title_fullStr |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
title_full_unstemmed |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
title_sort |
Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro |
author |
Silva, Eliane Cristine da |
author_facet |
Silva, Eliane Cristine da elianecsilva@uol.com.br |
author_role |
author |
author2 |
elianecsilva@uol.com.br |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Hirata Júnior, Raphael |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4484092525465200 |
dc.contributor.advisor2.fl_str_mv |
Guaraldi, Ana Luiza Mattos |
dc.contributor.advisor2Lattes.fl_str_mv |
http://lattes.cnpq.br/8091118564093203 |
dc.contributor.referee1.fl_str_mv |
Ignacio, Ana Claudia de Paula Rosa |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7809403473011306 |
dc.contributor.referee2.fl_str_mv |
Sant’Anna, Louisy Sanches dos Santos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5999066009401057 |
dc.contributor.referee3.fl_str_mv |
Napoleão, Fátima |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6368074603262304 |
dc.contributor.referee4.fl_str_mv |
Martins, Carlos Alberto de Souza |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/6457141178252146 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8322495800228245 |
dc.contributor.author.fl_str_mv |
Silva, Eliane Cristine da elianecsilva@uol.com.br |
contributor_str_mv |
Hirata Júnior, Raphael Guaraldi, Ana Luiza Mattos Ignacio, Ana Claudia de Paula Rosa Sant’Anna, Louisy Sanches dos Santos Napoleão, Fátima Martins, Carlos Alberto de Souza |
dc.subject.eng.fl_str_mv |
Corynebacterium striatum Corynebacterium amycolatum Blood culture |
topic |
Corynebacterium striatum Corynebacterium amycolatum Blood culture Corynebacterium striatum Corynebacterium amycolatum Hemocultura CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADA::MICROBIOLOGIA MEDICA |
dc.subject.por.fl_str_mv |
Corynebacterium striatum Corynebacterium amycolatum Hemocultura |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADA::MICROBIOLOGIA MEDICA |
description |
Corynebacteria are part of the commensal microbiota of humans and animals, and their isolation from clinical samples has been neglected by clinicians, since those microorganisms is usually considered as contaminants. The present study was conducted in a tertiary hospital in the city of Rio de Janeiro, and clinical strains of Corynebacterium spp. and other Gram positive bacilli of clinical importance, isolated from a total of 548 blood cultures of hospitalized patients in several hospital sections, from February to December 2015. The following species were characterized by the use of MALDI-TOF (Matrix Assisted laser Desorption Ionization – Time of Flight): Corynebacterium striatum (n=07), Corynebacterium amycolatum (n=03), Corynebacterium aurimucosum (n=01), Corynebacterium minutissimum (n=01), Brevibacterium ravespurgense (n=1), Dietzia maris (n=01), Listeria monocytogenes (n=02), Tsukamurella paurometabola (n=01). The dissemination of C. striatum was investigated using a Pulsed-field gel electrophoresis (PFGE) technique demonstrating the prevalence of a single clone named pulsotype IC, related to strains previously isolated in a hospital from Rio de Janeiro. C. striatum and C. amycolatum strains were resistant to multiple antimicrobials, and among the 24 antimicrobials tested, the C. striatum samples showed sensitivity only to vancomycin, linezolid and tetracycline. Both C. striatum and C. amycolatum strains produced biofilm at abiotic hydrophobic and hydrophilic surfaces. In addition, the strains were capable to adhere, survive and persist within type II pneumocytes (A549). In view of in vivo models, these pathogens were able to cause hematological changes in mice, as well as to promote mechanisms of pathogenicity and lethality to Caenorhabditis elegans helminth. These features corroborate the pathogenicity of C. striatum and C. amycolatum and their knowledge may support the development of strategies for the prevention, monitoring and control of infections by these agents in nosocomial environment. Thus, C. striatum and C. amycolatum should be considered as potential risk factors for hematogenous infections in hospitalized patients and surveillance measures should be taken to avoid preventing, monitoring and controlling such infections in nosocomial setting. Further studies on these and other virulence attributes and their relevance to the pathogenesis of corynebacteria remain necessary to minimize the involvement of these pathogens as etiological agents . |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-06-07 |
dc.date.accessioned.fl_str_mv |
2022-09-09T14:15:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Eliane Cristine da. Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro. 2018. 135 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2018. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/18349 |
identifier_str_mv |
SILVA, Eliane Cristine da. Caracterização de aspectos clínico-epidemiológicos e microbiológicos de amostras de Corynebacterium spp. isoladas de infecções hematogênicas de pacientes atendidos em hospital terciário da região metropolitana do Rio de Janeiro. 2018. 135 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2018. |
url |
http://www.bdtd.uerj.br/handle/1/18349 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Microbiologia |
dc.publisher.initials.fl_str_mv |
UERJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Faculdade de Ciências Médicas |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UERJ instname:Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
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Universidade do Estado do Rio de Janeiro (UERJ) |
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UERJ |
institution |
UERJ |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UERJ |
collection |
Biblioteca Digital de Teses e Dissertações da UERJ |
bitstream.url.fl_str_mv |
http://www.bdtd.uerj.br/bitstream/1/18349/2/Tese+-+Eliane+Cristine+da+Silva+-+2018+-+Completa http://www.bdtd.uerj.br/bitstream/1/18349/1/license.txt |
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509977a5f58831667051d744f6376fa7 e5502652da718045d7fcd832b79fca29 |
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MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ) |
repository.mail.fl_str_mv |
bdtd.suporte@uerj.br |
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1792352366033371136 |