Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions

Bibliographic Details
Main Author: Cotrim, Helma Pinchemel
Publication Date: 2004
Other Authors: Freitas, Luiz A. R. de, Freitas, Carolina, Braga, Luciana, Sousa, Rodrigo, Carvalho, Fernando
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/7541
Summary: Texto completo: acesso restrito. p. 131-135
id UFBA-2_0a4bba558922dc9ac0ed92724bb9f5f4
oai_identifier_str oai:repositorio.ufba.br:ri/7541
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Cotrim, Helma PinchemelFreitas, Luiz A. R. deFreitas, CarolinaBraga, LucianaSousa, RodrigoCarvalho, FernandoCotrim, Helma PinchemelFreitas, Luiz A. R. deFreitas, CarolinaBraga, LucianaSousa, RodrigoCarvalho, Fernando2012-12-14T14:03:06Z20041478-3223http://www.repositorio.ufba.br/ri/handle/ri/7541v. 24, n. 2Texto completo: acesso restrito. p. 131-135Background/Aims: Non-alcoholic steatohepatitis (NASH) has been associated with exposure to chemicals among workers from an industrial complex in Brazil. We investigated the NASH profile of these individuals associated or not with metabolic conditions. Methods: Eighty-four patients with NASH were classified into three groups: G1, 31 patients exposed to chemicals (benzene, xylene, vinyl chloride and others); G2, 30 exposed patients who also presented with obesity, hyperlipidemia and diabetes; and G3, 23 non-exposed patients who presented with metabolic conditions.Results: G1 and G2 were similar in terms of gender (97% and 100% males) and age (37 5.4 and 39 6.5 years). In G3, 74% were males and the age was 48 3.4 years (Po0.05). In G2, obesity was present in 26.6%, hyperlipidemia in 66.6% and diabetes in 6.6%. In G3, obesity was observed in 43.4%, hyperlipidemia in 30.4% and diabetes in 26%. Macro- and microsteatosis were observed in 100% of cases. Perisinusoidal fibrosis was observed in 71% patients in G1, 80% in G2 and 52% in G3 (Po0.05). Histological evidence of cholestasis was present in 53% of cases in G1, 50% in G2 and 13% in G3 (Po0.05). Conclusions: Exposure to chemicals appears to be an independent risk factor for NASH that presents a peculiar profile. It is more frequently seen in men younger than non-exposed ones. Steatosis, fibrosis and cholestasis were frequent histological findings. Co-existing metabolic factors did not seem to influence clinical or histopathological presentation.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-14T14:03:06Z No. of bitstreams: 1 j.1478-3231.2004.0897.x.pdf: 102706 bytes, checksum: 98810ed8c696395f1ef3affe8ab56df2 (MD5)Made available in DSpace on 2012-12-14T14:03:06Z (GMT). No. of bitstreams: 1 j.1478-3231.2004.0897.x.pdf: 102706 bytes, checksum: 98810ed8c696395f1ef3affe8ab56df2 (MD5) Previous issue date: 2004http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2004.0897.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAindustrial hepatotoxicitynonnonalcoholic steatohepatitisoccupational expoexposure to chemicalsClinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditionsLiver Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7541/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALj.1478-3231.2004.0897.x.pdfj.1478-3231.2004.0897.x.pdfapplication/pdf102706https://repositorio.ufba.br/bitstream/ri/7541/1/j.1478-3231.2004.0897.x.pdf98810ed8c696395f1ef3affe8ab56df2MD51TEXTj.1478-3231.2004.0897.x.pdf.txtj.1478-3231.2004.0897.x.pdf.txtExtracted texttext/plain22102https://repositorio.ufba.br/bitstream/ri/7541/3/j.1478-3231.2004.0897.x.pdf.txt68e2fdc01d5312b08f83639c47e15b74MD53ri/75412022-07-05 14:03:23.163oai:repositorio.ufba.br:ri/7541VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
dc.title.alternative.pt_BR.fl_str_mv Liver International
title Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
spellingShingle Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
Cotrim, Helma Pinchemel
industrial hepatotoxicity
non
nonalcoholic steatohepatitis
occupational expo
exposure to chemicals
title_short Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
title_full Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
title_fullStr Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
title_full_unstemmed Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
title_sort Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
author Cotrim, Helma Pinchemel
author_facet Cotrim, Helma Pinchemel
Freitas, Luiz A. R. de
Freitas, Carolina
Braga, Luciana
Sousa, Rodrigo
Carvalho, Fernando
author_role author
author2 Freitas, Luiz A. R. de
Freitas, Carolina
Braga, Luciana
Sousa, Rodrigo
Carvalho, Fernando
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cotrim, Helma Pinchemel
Freitas, Luiz A. R. de
Freitas, Carolina
Braga, Luciana
Sousa, Rodrigo
Carvalho, Fernando
Cotrim, Helma Pinchemel
Freitas, Luiz A. R. de
Freitas, Carolina
Braga, Luciana
Sousa, Rodrigo
Carvalho, Fernando
dc.subject.por.fl_str_mv industrial hepatotoxicity
non
nonalcoholic steatohepatitis
occupational expo
exposure to chemicals
topic industrial hepatotoxicity
non
nonalcoholic steatohepatitis
occupational expo
exposure to chemicals
description Texto completo: acesso restrito. p. 131-135
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-14T14:03:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7541
dc.identifier.issn.none.fl_str_mv 1478-3223
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 2
identifier_str_mv 1478-3223
v. 24, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/7541
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2004.0897.x/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/7541/2/license.txt
https://repositorio.ufba.br/bitstream/ri/7541/1/j.1478-3231.2004.0897.x.pdf
https://repositorio.ufba.br/bitstream/ri/7541/3/j.1478-3231.2004.0897.x.pdf.txt
bitstream.checksum.fl_str_mv 1b89a9a0548218172d7c829f87a0eab9
98810ed8c696395f1ef3affe8ab56df2
68e2fdc01d5312b08f83639c47e15b74
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1798057589403025408

Similar Items