Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7541 |
Resumo: | Texto completo: acesso restrito. p. 131-135 |
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Cotrim, Helma PinchemelFreitas, Luiz A. R. deFreitas, CarolinaBraga, LucianaSousa, RodrigoCarvalho, FernandoCotrim, Helma PinchemelFreitas, Luiz A. R. deFreitas, CarolinaBraga, LucianaSousa, RodrigoCarvalho, Fernando2012-12-14T14:03:06Z20041478-3223http://www.repositorio.ufba.br/ri/handle/ri/7541v. 24, n. 2Texto completo: acesso restrito. p. 131-135Background/Aims: Non-alcoholic steatohepatitis (NASH) has been associated with exposure to chemicals among workers from an industrial complex in Brazil. We investigated the NASH profile of these individuals associated or not with metabolic conditions. Methods: Eighty-four patients with NASH were classified into three groups: G1, 31 patients exposed to chemicals (benzene, xylene, vinyl chloride and others); G2, 30 exposed patients who also presented with obesity, hyperlipidemia and diabetes; and G3, 23 non-exposed patients who presented with metabolic conditions.Results: G1 and G2 were similar in terms of gender (97% and 100% males) and age (37 5.4 and 39 6.5 years). In G3, 74% were males and the age was 48 3.4 years (Po0.05). In G2, obesity was present in 26.6%, hyperlipidemia in 66.6% and diabetes in 6.6%. In G3, obesity was observed in 43.4%, hyperlipidemia in 30.4% and diabetes in 26%. Macro- and microsteatosis were observed in 100% of cases. Perisinusoidal fibrosis was observed in 71% patients in G1, 80% in G2 and 52% in G3 (Po0.05). Histological evidence of cholestasis was present in 53% of cases in G1, 50% in G2 and 13% in G3 (Po0.05). Conclusions: Exposure to chemicals appears to be an independent risk factor for NASH that presents a peculiar profile. It is more frequently seen in men younger than non-exposed ones. Steatosis, fibrosis and cholestasis were frequent histological findings. Co-existing metabolic factors did not seem to influence clinical or histopathological presentation.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-14T14:03:06Z No. of bitstreams: 1 j.1478-3231.2004.0897.x.pdf: 102706 bytes, checksum: 98810ed8c696395f1ef3affe8ab56df2 (MD5)Made available in DSpace on 2012-12-14T14:03:06Z (GMT). No. of bitstreams: 1 j.1478-3231.2004.0897.x.pdf: 102706 bytes, checksum: 98810ed8c696395f1ef3affe8ab56df2 (MD5) Previous issue date: 2004http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2004.0897.x/pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAindustrial hepatotoxicitynonnonalcoholic steatohepatitisoccupational expoexposure to chemicalsClinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditionsLiver Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7541/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALj.1478-3231.2004.0897.x.pdfj.1478-3231.2004.0897.x.pdfapplication/pdf102706https://repositorio.ufba.br/bitstream/ri/7541/1/j.1478-3231.2004.0897.x.pdf98810ed8c696395f1ef3affe8ab56df2MD51TEXTj.1478-3231.2004.0897.x.pdf.txtj.1478-3231.2004.0897.x.pdf.txtExtracted texttext/plain22102https://repositorio.ufba.br/bitstream/ri/7541/3/j.1478-3231.2004.0897.x.pdf.txt68e2fdc01d5312b08f83639c47e15b74MD53ri/75412022-07-05 14:03:23.163oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
dc.title.alternative.pt_BR.fl_str_mv |
Liver International |
title |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
spellingShingle |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions Cotrim, Helma Pinchemel industrial hepatotoxicity non nonalcoholic steatohepatitis occupational expo exposure to chemicals |
title_short |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
title_full |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
title_fullStr |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
title_full_unstemmed |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
title_sort |
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions |
author |
Cotrim, Helma Pinchemel |
author_facet |
Cotrim, Helma Pinchemel Freitas, Luiz A. R. de Freitas, Carolina Braga, Luciana Sousa, Rodrigo Carvalho, Fernando |
author_role |
author |
author2 |
Freitas, Luiz A. R. de Freitas, Carolina Braga, Luciana Sousa, Rodrigo Carvalho, Fernando |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cotrim, Helma Pinchemel Freitas, Luiz A. R. de Freitas, Carolina Braga, Luciana Sousa, Rodrigo Carvalho, Fernando Cotrim, Helma Pinchemel Freitas, Luiz A. R. de Freitas, Carolina Braga, Luciana Sousa, Rodrigo Carvalho, Fernando |
dc.subject.por.fl_str_mv |
industrial hepatotoxicity non nonalcoholic steatohepatitis occupational expo exposure to chemicals |
topic |
industrial hepatotoxicity non nonalcoholic steatohepatitis occupational expo exposure to chemicals |
description |
Texto completo: acesso restrito. p. 131-135 |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2012-12-14T14:03:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/7541 |
dc.identifier.issn.none.fl_str_mv |
1478-3223 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 24, n. 2 |
identifier_str_mv |
1478-3223 v. 24, n. 2 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/7541 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2004.0897.x/pdf |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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