Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages

Detalhes bibliográficos
Autor(a) principal: Soares, N. M.
Data de Publicação: 2010
Outros Autores: Leal, T. F., Fiúza, M. C., Reis, E. A. G., Souza, M. A. L., Santos, W. L. dos, Carvalho, Lain Carlos Pontes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5846
Resumo: Trabalho completo: acesso restrito, p. 259–266
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spelling Soares, N. M.Leal, T. F.Fiúza, M. C.Reis, E. A. G.Souza, M. A. L.Santos, W. L. dosCarvalho, Lain Carlos Pontes deSoares, N. M.Leal, T. F.Fiúza, M. C.Reis, E. A. G.Souza, M. A. L.Santos, W. L. dosCarvalho, Lain Carlos Pontes de2012-05-11T20:12:55Z2010-040141-9838http://www.repositorio.ufba.br/ri/handle/ri/5846v. 32, n. 4Trabalho completo: acesso restrito, p. 259–266This work aimed at investigating the lipid profile of zoonotic visceral leishmaniasis (VL) patients’ sera and the effect of lipoproteins on the in vitro production of tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10 and IL-12 by Leishmania infantum-infected and uninfected macrophages. Lipids were quantified in 26 VL patients’ sera and 26 healthy controls from a VL endemic area. The patients’ sera had higher triglyceride and very low density lipoprotein (VLDL) levels, and much lower apolipoprotein A1, total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) levels than the control sera. Lipoprotein fractions were obtained by ultracentrifugation of sera. The addition of LDL and HDL to Leishmania-infected and uninfected macrophages, in physiological concentrations, enhanced the production of IL-6 and IL-10, but not of IL-12. LDL stimulated the production of TNF-α only in infected macrophages, whereas HDL stimulated the production of lower amounts of TNF-α in both infected and uninfected macrophages. VLDL stimulated only the production of IL-10. It is proposed herein that LDL may influence the development of VL by promoting the production of TNF-α by infected macrophages. A decrease in plasma LDL in some VL patients (to 20 mg/mL or less); however, would tend to reduce the production of TNF-α and therefore to limit the development of immune-mediated pathology, not withstanding the fact that it would perhaps increase the permissiveness of macrophages to Leishmania growth.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-11T20:12:55Z No. of bitstreams: 1 (14)j.1365-3024.2009.01187.x.pdf: 289581 bytes, checksum: 3e5ad12c855fc824f7d44ae0902a861d (MD5)Made available in DSpace on 2012-05-11T20:12:55Z (GMT). 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dc.title.pt_BR.fl_str_mv Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
spellingShingle Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
Soares, N. M.
cytokines
Leishmania
lipoproteins
title_short Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_full Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_fullStr Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_full_unstemmed Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_sort Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
author Soares, N. M.
author_facet Soares, N. M.
Leal, T. F.
Fiúza, M. C.
Reis, E. A. G.
Souza, M. A. L.
Santos, W. L. dos
Carvalho, Lain Carlos Pontes de
author_role author
author2 Leal, T. F.
Fiúza, M. C.
Reis, E. A. G.
Souza, M. A. L.
Santos, W. L. dos
Carvalho, Lain Carlos Pontes de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, N. M.
Leal, T. F.
Fiúza, M. C.
Reis, E. A. G.
Souza, M. A. L.
Santos, W. L. dos
Carvalho, Lain Carlos Pontes de
Soares, N. M.
Leal, T. F.
Fiúza, M. C.
Reis, E. A. G.
Souza, M. A. L.
Santos, W. L. dos
Carvalho, Lain Carlos Pontes de
dc.subject.por.fl_str_mv cytokines
Leishmania
lipoproteins
topic cytokines
Leishmania
lipoproteins
description Trabalho completo: acesso restrito, p. 259–266
publishDate 2010
dc.date.issued.fl_str_mv 2010-04
dc.date.accessioned.fl_str_mv 2012-05-11T20:12:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5846
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 32, n. 4
identifier_str_mv 0141-9838
v. 32, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/5846
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons A/S
publisher.none.fl_str_mv John Wiley & Sons A/S
dc.source.pt_BR.fl_str_mv 10.1111/j.1365-3024.2009.01187.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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