Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis

Detalhes bibliográficos
Autor(a) principal: Alves, Crésio de Aragão Dantas
Data de Publicação: 2010
Outros Autores: Lima, Daniela Seabra, Cardeal, Mauricio, Santana, Angelica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12103
Resumo: Texto completo: acesso restrito. p.493-497
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spelling Alves, Crésio de Aragão DantasLima, Daniela SeabraCardeal, MauricioSantana, AngelicaAlves, Crésio de Aragão DantasLima, Daniela SeabraCardeal, MauricioSantana, Angelica2013-07-04T16:36:26Z2010-111399-543Xhttp://www.repositorio.ufba.br/ri/handle/ri/12103v. 11, n. 7Texto completo: acesso restrito. p.493-497Objective: To evaluate glucose tolerance in racially mixed Brazilian youth with cystic fibrosis (CF). Methods: Cross-sectional study conducted between August and September 2007, at a reference service for CF, evaluating: glycated hemoglobin (HbA1c), blood glucose, and insulin levels, before and 2 h after a glucose overload. Results: There were 46 patients aged between 6 yr and 16 yr and 2 months (median: 9 yr and 10 months) of whom 64% were boys. Of these, 26% were Whites; 54.4% Mulattoes; and 19.6% Blacks. HbA1c was normal in all patients. Only one participant (12-yr old) had glucose intolerance. Insulin levels ranged from 1 to 23 µIU/mL (median: 4.5 µIU/mL) at baseline and from 3.2 to 192.1 µIU/mL (median: 11 µIU/mL) after a glucose overload. Insulin resistance evaluated by the HOMA index, stratified by sex and age, was present in three patients. The ΔF508 mutation was present in only 4.3% of the sample, all of them being heterozygous. Conclusions: The low prevalence of carbohydrate intolerance in this population is probably a result of their young age. Another possibility is the low frequency of the ΔF508 mutation. Although not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-04T15:57:58Z No. of bitstreams: 1 j.1399-5448.2010.00639.x.pdf: 498355 bytes, checksum: 0dbbdabf9b09a101bb9b15ba1c5bc54d (MD5)Approved for entry into archive by NELIJANE MENEZES(rubi2276@gmail.com) on 2013-07-04T16:36:26Z (GMT) No. of bitstreams: 1 j.1399-5448.2010.00639.x.pdf: 498355 bytes, checksum: 0dbbdabf9b09a101bb9b15ba1c5bc54d (MD5)Made available in DSpace on 2013-07-04T16:36:26Z (GMT). No. of bitstreams: 1 j.1399-5448.2010.00639.x.pdf: 498355 bytes, checksum: 0dbbdabf9b09a101bb9b15ba1c5bc54d (MD5) Previous issue date: 2010-11http://dx.doi.org/10.1111/j.1399-5448.2010.00639.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACystic fibrosisDiabetes mellitusGlucose intoleranceRace/ethnicityLow prevalence of glucose intolerance in racially mixed children with cystic fibrosisPediatric Diabetesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALj.1399-5448.2010.00639.x.pdfj.1399-5448.2010.00639.x.pdfapplication/pdf498355https://repositorio.ufba.br/bitstream/ri/12103/1/j.1399-5448.2010.00639.x.pdf0dbbdabf9b09a101bb9b15ba1c5bc54dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12103/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1399-5448.2010.00639.x.pdf.txtj.1399-5448.2010.00639.x.pdf.txtExtracted texttext/plain20438https://repositorio.ufba.br/bitstream/ri/12103/3/j.1399-5448.2010.00639.x.pdf.txt65f4be9d06502f7e5d663e16e9ef436eMD53ri/121032022-08-08 13:17:27.378oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
dc.title.alternative.pt_BR.fl_str_mv Pediatric Diabetes
title Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
spellingShingle Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
Alves, Crésio de Aragão Dantas
Cystic fibrosis
Diabetes mellitus
Glucose intolerance
Race/ethnicity
title_short Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
title_full Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
title_fullStr Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
title_full_unstemmed Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
title_sort Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
author Alves, Crésio de Aragão Dantas
author_facet Alves, Crésio de Aragão Dantas
Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
author_role author
author2 Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
author2_role author
author
author
dc.contributor.author.fl_str_mv Alves, Crésio de Aragão Dantas
Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
Alves, Crésio de Aragão Dantas
Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
dc.subject.por.fl_str_mv Cystic fibrosis
Diabetes mellitus
Glucose intolerance
Race/ethnicity
topic Cystic fibrosis
Diabetes mellitus
Glucose intolerance
Race/ethnicity
description Texto completo: acesso restrito. p.493-497
publishDate 2010
dc.date.issued.fl_str_mv 2010-11
dc.date.accessioned.fl_str_mv 2013-07-04T16:36:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12103
dc.identifier.issn.none.fl_str_mv 1399-543X
dc.identifier.number.pt_BR.fl_str_mv v. 11, n. 7
identifier_str_mv 1399-543X
v. 11, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/12103
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1399-5448.2010.00639.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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