Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin

Detalhes bibliográficos
Autor(a) principal: Lima, Flávia Oliveira de
Data de Publicação: 2011
Outros Autores: Nonato, Fabiana Regina, Couto, Ricardo David, Barbosa Filho, José Maria, Nunes, Xirley Pereira, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5487
Resumo: p. 596-602
id UFBA-2_5888f774a53375adae71dc549c583cc4
oai_identifier_str oai:repositorio.ufba.br:ri/5487
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Lima, Flávia Oliveira deNonato, Fabiana ReginaCouto, Ricardo DavidBarbosa Filho, José MariaNunes, Xirley PereiraSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane FloraLima, Flávia Oliveira deNonato, Fabiana ReginaCouto, Ricardo DavidBarbosa Filho, José MariaNunes, Xirley PereiraSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2012-03-02T12:23:00Z2012-03-02T12:23:00Z20110974-5211http://www.repositorio.ufba.br/ri/handle/ri/5487v. 74, n. 4.p. 596-6027-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-02T12:23:00Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5)Made available in DSpace on 2012-03-02T12:23:00Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5) Previous issue date: 2011DOI: 10.1021/np100621creponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMechanisms Involved in the Antinociceptive Effects of 7-HydroxycoumarinJOURNAL OF NATURAL PRODUCTSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdfC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdfapplication/pdf275086https://repositorio.ufba.br/bitstream/ri/5487/1/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf1b60c6ff0f48421176622c1ede9f1263MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5487/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txtC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txtExtracted texttext/plain36231https://repositorio.ufba.br/bitstream/ri/5487/3/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txt2e65c4b716ae6ce02b429bc7f5e1ca52MD53ri/54872022-07-05 14:03:21.048oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
dc.title.alternative.pt_BR.fl_str_mv JOURNAL OF NATURAL PRODUCTS
title Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
spellingShingle Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
Lima, Flávia Oliveira de
title_short Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
title_full Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
title_fullStr Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
title_full_unstemmed Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
title_sort Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
author Lima, Flávia Oliveira de
author_facet Lima, Flávia Oliveira de
Nonato, Fabiana Regina
Couto, Ricardo David
Barbosa Filho, José Maria
Nunes, Xirley Pereira
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Nonato, Fabiana Regina
Couto, Ricardo David
Barbosa Filho, José Maria
Nunes, Xirley Pereira
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Flávia Oliveira de
Nonato, Fabiana Regina
Couto, Ricardo David
Barbosa Filho, José Maria
Nunes, Xirley Pereira
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Lima, Flávia Oliveira de
Nonato, Fabiana Regina
Couto, Ricardo David
Barbosa Filho, José Maria
Nunes, Xirley Pereira
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
description p. 596-602
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-03-02T12:23:00Z
dc.date.available.fl_str_mv 2012-03-02T12:23:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5487
dc.identifier.issn.none.fl_str_mv 0974-5211
dc.identifier.number.pt_BR.fl_str_mv v. 74, n. 4.
identifier_str_mv 0974-5211
v. 74, n. 4.
url http://www.repositorio.ufba.br/ri/handle/ri/5487
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1021/np100621c
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/5487/1/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf
https://repositorio.ufba.br/bitstream/ri/5487/2/license.txt
https://repositorio.ufba.br/bitstream/ri/5487/3/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txt
bitstream.checksum.fl_str_mv 1b60c6ff0f48421176622c1ede9f1263
1b89a9a0548218172d7c829f87a0eab9
2e65c4b716ae6ce02b429bc7f5e1ca52
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1793970062423490560

Registros relacionados