Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13810 |
Resumo: | Texto completo: acesso restrito. p. 205-213 |
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Barros, Taís Adelita de AlmeidaFreitas, Luis A. R. deB. Filho, José M.Nunes, Xirley PereiraGiulietti, Ana M.Souza, Glória Emilia Petto deSantos, Ricardo R. dosSoares, Milena Botelho PereiraVillarreal, Cristiane FloraBarros, Taís Adelita de AlmeidaFreitas, Luis A. R. deB. Filho, José M.Nunes, Xirley PereiraGiulietti, Ana M.Souza, Glória Emilia Petto deSantos, Ricardo R. dosSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2013-11-19T20:59:24Z20100022-3573http://repositorio.ufba.br/ri/handle/ri/13810v. 62, n. 2Texto completo: acesso restrito. p. 205-213Objectives In the present study we investigated the antinociceptive, anti-inflammatory and antipyretic effects of 7-hydroxycoumarin (7-HC) in animal models. Methods The effects of oral 7-HC were tested against acetic acid-induced writhing, formalin test, tail flick test, complete Freund's adjuvant (CFA)-induced hypernociception, carrageenan-induced paw oedema, lipopolysaccharide-induced fever and the rota rod test. Key findings 7-HC (3–60 mg/kg) produced a dose-related antinociception against acetic acid-induced writhing in mice and in the formalin test. In contrast, treatment with 7-HC did not prevent thermal nociception in the tail flick test. A single treatment with 7-HC, 60 mg/kg, produced a long-lasting antinociceptive effect against CFA-induced hypernociception, a chronic inflammatory pain stimulus. Notably, at 60 mg/kg per day over 4 days the administration of 7-HC produced a continuous antinociceptive effect against CFA-induced hypernociception. 7-HC (30–120 mg/kg) produced anti-inflammatory and antipyretic effects against carrageenan-induced inflammation and lipopolysaccharide-induced fever, respectively. Moreover, 7-HC was found to be safe with respect to ulcer induction. In the rota rod test, 7-HC-treated mice did not show any motor performance alterations. Conclusions The prolonged antinociceptive and anti-inflammatory effects of 7-HC, in association with its low ulcerogenic activity, indicate that this molecule might be a good candidate for development of new drugs for the control of chronic inflammatory pain and fever.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-09T18:44:20Z No. of bitstreams: 1 jpp.62.02.0008.pdf: 744254 bytes, checksum: 0b8d923ef8e7f92586fb6eda00330f06 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:59:24Z (GMT) No. of bitstreams: 1 jpp.62.02.0008.pdf: 744254 bytes, checksum: 0b8d923ef8e7f92586fb6eda00330f06 (MD5)Made available in DSpace on 2013-11-19T20:59:24Z (GMT). No. of bitstreams: 1 jpp.62.02.0008.pdf: 744254 bytes, checksum: 0b8d923ef8e7f92586fb6eda00330f06 (MD5) Previous issue date: 2010http://dx.doi.org/10.1211/jpp.62.02.0008reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBA7-hydroxycoumarinAntiinflammatoryAntinociceptionantipyreticchronic paingastric toxicityAntinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic painJournal of Pharmacy and Pharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALjpp.62.02.0008.pdfjpp.62.02.0008.pdfapplication/pdf744254https://repositorio.ufba.br/bitstream/ri/13810/1/jpp.62.02.0008.pdf0b8d923ef8e7f92586fb6eda00330f06MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13810/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTjpp.62.02.0008.pdf.txtjpp.62.02.0008.pdf.txtExtracted texttext/plain43000https://repositorio.ufba.br/bitstream/ri/13810/3/jpp.62.02.0008.pdf.txtf39ed94a3ecb689d23f25b9c6f8dd689MD53ri/138102022-08-08 13:17:36.83oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:36Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Pharmacy and Pharmacology |
| title |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| spellingShingle |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain Barros, Taís Adelita de Almeida 7-hydroxycoumarin Antiinflammatory Antinociception antipyretic chronic pain gastric toxicity |
| title_short |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| title_full |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| title_fullStr |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| title_full_unstemmed |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| title_sort |
Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain |
| author |
Barros, Taís Adelita de Almeida |
| author_facet |
Barros, Taís Adelita de Almeida Freitas, Luis A. R. de B. Filho, José M. Nunes, Xirley Pereira Giulietti, Ana M. Souza, Glória Emilia Petto de Santos, Ricardo R. dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author_role |
author |
| author2 |
Freitas, Luis A. R. de B. Filho, José M. Nunes, Xirley Pereira Giulietti, Ana M. Souza, Glória Emilia Petto de Santos, Ricardo R. dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros, Taís Adelita de Almeida Freitas, Luis A. R. de B. Filho, José M. Nunes, Xirley Pereira Giulietti, Ana M. Souza, Glória Emilia Petto de Santos, Ricardo R. dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora Barros, Taís Adelita de Almeida Freitas, Luis A. R. de B. Filho, José M. Nunes, Xirley Pereira Giulietti, Ana M. Souza, Glória Emilia Petto de Santos, Ricardo R. dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| dc.subject.por.fl_str_mv |
7-hydroxycoumarin Antiinflammatory Antinociception antipyretic chronic pain gastric toxicity |
| topic |
7-hydroxycoumarin Antiinflammatory Antinociception antipyretic chronic pain gastric toxicity |
| description |
Texto completo: acesso restrito. p. 205-213 |
| publishDate |
2010 |
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2010 |
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2013-11-19T20:59:24Z |
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0022-3573 |
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v. 62, n. 2 |
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0022-3573 v. 62, n. 2 |
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http://repositorio.ufba.br/ri/handle/ri/13810 |
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