Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin
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Publication Date: | 2011 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFBA |
Download full: | http://www.repositorio.ufba.br/ri/handle/ri/5487 |
Summary: | p. 596-602 |
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Lima, Flávia Oliveira deNonato, Fabiana ReginaCouto, Ricardo DavidBarbosa Filho, José MariaNunes, Xirley PereiraSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane FloraLima, Flávia Oliveira deNonato, Fabiana ReginaCouto, Ricardo DavidBarbosa Filho, José MariaNunes, Xirley PereiraSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2012-03-02T12:23:00Z2012-03-02T12:23:00Z20110974-5211http://www.repositorio.ufba.br/ri/handle/ri/5487v. 74, n. 4.p. 596-6027-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-02T12:23:00Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5)Made available in DSpace on 2012-03-02T12:23:00Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf: 275086 bytes, checksum: 1b60c6ff0f48421176622c1ede9f1263 (MD5) Previous issue date: 2011DOI: 10.1021/np100621creponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMechanisms Involved in the Antinociceptive Effects of 7-HydroxycoumarinJOURNAL OF NATURAL PRODUCTSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdfC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdfapplication/pdf275086https://repositorio.ufba.br/bitstream/ri/5487/1/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf1b60c6ff0f48421176622c1ede9f1263MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5487/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txtC__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txtExtracted texttext/plain36231https://repositorio.ufba.br/bitstream/ri/5487/3/C__Documents%20and%20Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf.txt2e65c4b716ae6ce02b429bc7f5e1ca52MD53ri/54872022-07-05 14:03:21.048oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
dc.title.alternative.pt_BR.fl_str_mv |
JOURNAL OF NATURAL PRODUCTS |
title |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
spellingShingle |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin Lima, Flávia Oliveira de |
title_short |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
title_full |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
title_fullStr |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
title_full_unstemmed |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
title_sort |
Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
author |
Lima, Flávia Oliveira de |
author_facet |
Lima, Flávia Oliveira de Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
author_role |
author |
author2 |
Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Flávia Oliveira de Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora Lima, Flávia Oliveira de Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
description |
p. 596-602 |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2012-03-02T12:23:00Z |
dc.date.available.fl_str_mv |
2012-03-02T12:23:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5487 |
dc.identifier.issn.none.fl_str_mv |
0974-5211 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 74, n. 4. |
identifier_str_mv |
0974-5211 v. 74, n. 4. |
url |
http://www.repositorio.ufba.br/ri/handle/ri/5487 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.source.pt_BR.fl_str_mv |
DOI: 10.1021/np100621c |
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