Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6194 |
Resumo: | Trabalho completo: acesso restrito, p. 3843-3850 |
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Macambira, Simone GarciaVasconcelos, Juliana FragaCosta, Claudio R. S.Klein, WilfriedLima, Ricardo S.Guimarães, PatríciaVidal, Daniel T. A.Mendez, Lucas C.Santos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraMacambira, Simone GarciaVasconcelos, Juliana FragaCosta, Claudio R. S.Klein, WilfriedLima, Ricardo S.Guimarães, PatríciaVidal, Daniel T. A.Mendez, Lucas C.Santos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2012-06-20T20:38:56Z2009-110892-6638http://www.repositorio.ufba.br/ri/handle/ri/6194v. 23, n. 11Trabalho completo: acesso restrito, p. 3843-3850This study investigates the effects of granulocyte colony-stimulating factor (G-CSF) therapy in experimental chronic chagasic cardiomyopathy. Chagas disease is one of the leading causes of heart failure in Latin America and remains without an effective treatment other than cardiac transplantation. C57BL/6 mice were infected with 103 trypomastigotes of Trypanosoma cruzi, and chronic chagasic mice were treated with G-CSF or saline (control). Evaluations following treatment were functional, immunological, and histopathological. Comparing hearts of G-CSFtreated mice showed reduced inflammation and fibrosis compared to saline-treated chagasic mice. G-CSF treatment did not alter the parasite load but caused an increase in the number of apoptotic inflammatory cells in the heart. Cardiac conductance disturbances in all infected animals improved or remained stable due to the G-CSF treatment, whereas all of the saline-treated mice deteriorated. The distance run on a treadmill and the exercise time were significantly greater in G-CSFtreated mice when compared to chagasic controls, as well as oxygen consumption (V˙ O2), carbon dioxide production (V˙ CO2), and respiratory exchange ration (RER) during exercise. Administration of G-CSF in experimental cardiac ischemia had beneficial effects on cardiac structure, which were well correlated with improvements in cardiac function and whole animal performance.— Macambira, S. G., Vasconcelos, J. F., Costa, C. R. S., Klein, W., Lima, R. S., Guimara˜es, P., Vidal, D. T. A., Mendez, L. C., Ribeiro-dos-Santos, R., Soares, M. B. P. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-20T20:38:56Z No. of bitstreams: 1 (81)3843.full.pdf: 1316507 bytes, checksum: 63c35205e5bb09d4d24366fe35a602bc (MD5)Made available in DSpace on 2012-06-20T20:38:56Z (GMT). No. of bitstreams: 1 (81)3843.full.pdf: 1316507 bytes, checksum: 63c35205e5bb09d4d24366fe35a602bc (MD5) Previous issue date: 2009-11Federation of American Society of Experimental Biologyhttp://www.fasebj.org/content/23/11/3843.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAchagasic cardiomyopathyinflammationarrhythmiastreadmill performanceGranulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and functionFaseb Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(81)3843.full.pdf(81)3843.full.pdfapplication/pdf1316507https://repositorio.ufba.br/bitstream/ri/6194/1/%2881%293843.full.pdf63c35205e5bb09d4d24366fe35a602bcMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6194/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(81)3843.full.pdf.txt(81)3843.full.pdf.txtExtracted texttext/plain37474https://repositorio.ufba.br/bitstream/ri/6194/3/%2881%293843.full.pdf.txt16debfe8340b1acf859740327a5397dfMD53ri/61942022-07-05 14:03:42.476oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| dc.title.alternative.pt_BR.fl_str_mv |
Faseb Journal |
| title |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| spellingShingle |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function Macambira, Simone Garcia chagasic cardiomyopathy inflammation arrhythmias treadmill performance |
| title_short |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| title_full |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| title_fullStr |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| title_full_unstemmed |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| title_sort |
Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function |
| author |
Macambira, Simone Garcia |
| author_facet |
Macambira, Simone Garcia Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Macambira, Simone Garcia Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Macambira, Simone Garcia Vasconcelos, Juliana Fraga Costa, Claudio R. S. Klein, Wilfried Lima, Ricardo S. Guimarães, Patrícia Vidal, Daniel T. A. Mendez, Lucas C. Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.por.fl_str_mv |
chagasic cardiomyopathy inflammation arrhythmias treadmill performance |
| topic |
chagasic cardiomyopathy inflammation arrhythmias treadmill performance |
| description |
Trabalho completo: acesso restrito, p. 3843-3850 |
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2009 |
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2009-11 |
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2012-06-20T20:38:56Z |
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info:eu-repo/semantics/publishedVersion |
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0892-6638 |
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v. 23, n. 11 |
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0892-6638 v. 23, n. 11 |
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Federation of American Society of Experimental Biology |
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Federation of American Society of Experimental Biology |
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