Antiphospholipid antibodies in HIV-positive patients

Detalhes bibliográficos
Autor(a) principal: Galrão, Liliana
Data de Publicação: 2007
Outros Autores: Brites, Carlos, Atta, Maria Luiza Brito de Sousa, Atta, Ajax Mercês, Lima, Isabella, Gonzalez, Fernanda, Magalhães, Fernanda, Santiago, Mittermayer Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15913
Resumo: Texto completo: acesso restrito. p. 1825-1830
id UFBA-2_a2e79c78a28b6b2e54d0f42d44ad7281
oai_identifier_str oai:repositorio.ufba.br:ri/15913
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Galrão, LilianaBrites, CarlosAtta, Maria Luiza Brito de SousaAtta, Ajax MercêsLima, IsabellaGonzalez, FernandaMagalhães, FernandaSantiago, Mittermayer BarretoGalrão, LilianaBrites, CarlosAtta, Maria Luiza Brito de SousaAtta, Ajax MercêsLima, IsabellaGonzalez, FernandaMagalhães, FernandaSantiago, Mittermayer Barreto2014-09-09T15:08:25Z20070770-3198http://repositorio.ufba.br/ri/handle/ri/15913v. 26, n. 11Texto completo: acesso restrito. p. 1825-1830Antiphospholipid (aPL) antibodies classically have been associated with thrombotic phenomena and abortion in patients with autoimmune diseases. The objective of the present work was to evaluate the frequency of such antibodies in patients infected with HIV and study its association with the presence of clinical manifestations of antiphospholipid syndrome (APS). Using a transversal study, a population of patients diagnosed with HIV, identified through an enzyme-linked immunosorbent assay (ELISA) test and confirmed by Western blotting, aged above 17 years old, was investigated. Through a standard questionnaire, the presence of APS manifestations was investigated, as well as the frequency of rheumatic manifestations. Antibodies against β2 glycoprotein I (anti-β2 GPI) and anticardiolipin (aCL) IgA, IgG, and IgM were investigated by the ELISA method using commercial kits (QUANTA Lite, INOVA Diagnostics). Ninety patients were studied, 47 (52.2%) male and 43 (47.8%) female. Clinical manifestations of APS were detected in 12 patients (13.3%) of the studied population, whereas arthralgia was the most common rheumatic manifestation (38.9%). Of the 90 patients, 40 (44.4%) were reactive for at least one type of aPL antibody (aCL and/or anti-β2 GPI). The frequency of aCL was 17.8%, from which 15 (16.7%) had aCL IgG, 3 (3.3%) IgM, and 1 (1.1%) IgA. The frequency of the anti-β2 GPI antibody was 33.3%, from which 29 (32.2%) were positive for isotype IgA, 4 (4.4%) isotype IgM, and 1 (1.1%) isotype IgG. No association was observed between immunoreactivity for aPL antibodies in general or each isotype in particular and the presence of APS manifestation. In the present study, it was possible to observe a relatively high frequency of aPL antibodies, particularly for isotype IgA anti-β2 GPI in HIV. However, there was no association to APS manifestations, suggesting that such antibodies had no etiopathogenic role in these complications in patients with such retroviral infection.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-13T13:18:11Z No. of bitstreams: 1 art%3A10.1007%2Fs10067-007-0581-6.pdf: 147869 bytes, checksum: a7d5aa6c0ec4e0b53f0fd3ecb3c178cc (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T15:08:25Z (GMT) No. of bitstreams: 1 art%3A10.1007%2Fs10067-007-0581-6.pdf: 147869 bytes, checksum: a7d5aa6c0ec4e0b53f0fd3ecb3c178cc (MD5)Made available in DSpace on 2014-09-09T15:08:25Z (GMT). No. of bitstreams: 1 art%3A10.1007%2Fs10067-007-0581-6.pdf: 147869 bytes, checksum: a7d5aa6c0ec4e0b53f0fd3ecb3c178cc (MD5) Previous issue date: 2007http://dx.doi.org/10.1007/s10067-007-0581-6reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntiphospholipid antibodiesAntiphospholipid syndromeHIVIgAAntiphospholipid antibodies in HIV-positive patientsClinical Rheumatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15913/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52ORIGINALart%3A10.1007%2Fs10067-007-0581-6.pdfart%3A10.1007%2Fs10067-007-0581-6.pdfapplication/pdf147869https://repositorio.ufba.br/bitstream/ri/15913/1/art%253A10.1007%252Fs10067-007-0581-6.pdfa7d5aa6c0ec4e0b53f0fd3ecb3c178ccMD51TEXTart%3A10.1007%2Fs10067-007-0581-6.pdf.txtart%3A10.1007%2Fs10067-007-0581-6.pdf.txtExtracted texttext/plain28790https://repositorio.ufba.br/bitstream/ri/15913/3/art%253A10.1007%252Fs10067-007-0581-6.pdf.txte43bb407efd1d5852eb97501b24d5794MD53ri/159132022-07-05 14:03:32.002oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:32Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Antiphospholipid antibodies in HIV-positive patients
dc.title.alternative.pt_BR.fl_str_mv Clinical Rheumatology
title Antiphospholipid antibodies in HIV-positive patients
spellingShingle Antiphospholipid antibodies in HIV-positive patients
Galrão, Liliana
Antiphospholipid antibodies
Antiphospholipid syndrome
HIV
IgA
title_short Antiphospholipid antibodies in HIV-positive patients
title_full Antiphospholipid antibodies in HIV-positive patients
title_fullStr Antiphospholipid antibodies in HIV-positive patients
title_full_unstemmed Antiphospholipid antibodies in HIV-positive patients
title_sort Antiphospholipid antibodies in HIV-positive patients
author Galrão, Liliana
author_facet Galrão, Liliana
Brites, Carlos
Atta, Maria Luiza Brito de Sousa
Atta, Ajax Mercês
Lima, Isabella
Gonzalez, Fernanda
Magalhães, Fernanda
Santiago, Mittermayer Barreto
author_role author
author2 Brites, Carlos
Atta, Maria Luiza Brito de Sousa
Atta, Ajax Mercês
Lima, Isabella
Gonzalez, Fernanda
Magalhães, Fernanda
Santiago, Mittermayer Barreto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Galrão, Liliana
Brites, Carlos
Atta, Maria Luiza Brito de Sousa
Atta, Ajax Mercês
Lima, Isabella
Gonzalez, Fernanda
Magalhães, Fernanda
Santiago, Mittermayer Barreto
Galrão, Liliana
Brites, Carlos
Atta, Maria Luiza Brito de Sousa
Atta, Ajax Mercês
Lima, Isabella
Gonzalez, Fernanda
Magalhães, Fernanda
Santiago, Mittermayer Barreto
dc.subject.por.fl_str_mv Antiphospholipid antibodies
Antiphospholipid syndrome
HIV
IgA
topic Antiphospholipid antibodies
Antiphospholipid syndrome
HIV
IgA
description Texto completo: acesso restrito. p. 1825-1830
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-09-09T15:08:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15913
dc.identifier.issn.none.fl_str_mv 0770-3198
dc.identifier.number.pt_BR.fl_str_mv v. 26, n. 11
identifier_str_mv 0770-3198
v. 26, n. 11
url http://repositorio.ufba.br/ri/handle/ri/15913
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1007/s10067-007-0581-6
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/15913/2/license.txt
https://repositorio.ufba.br/bitstream/ri/15913/1/art%253A10.1007%252Fs10067-007-0581-6.pdf
https://repositorio.ufba.br/bitstream/ri/15913/3/art%253A10.1007%252Fs10067-007-0581-6.pdf.txt
bitstream.checksum.fl_str_mv ff6eaa8b858ea317fded99f125f5fcd0
a7d5aa6c0ec4e0b53f0fd3ecb3c178cc
e43bb407efd1d5852eb97501b24d5794
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1793970131767918592

Registros relacionados