Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil

Detalhes bibliográficos
Autor(a) principal: Santos, Luciane Amorim
Data de Publicação: 2011
Outros Autores: Cunha, Joana Paixao Monteiro, Araujo, Adriano Fernando, Brites, Carlos, Castro, Bernardo Galvão, Alcântara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16675
Resumo: Texto completo: acesso restrito. p. 2066–2072
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spelling Santos, Luciane AmorimCunha, Joana Paixao MonteiroAraujo, Adriano FernandoBrites, CarlosCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorSantos, Luciane AmorimCunha, Joana Paixao MonteiroAraujo, Adriano FernandoBrites, CarlosCastro, Bernardo GalvãoAlcântara, Luiz Carlos Júnior2014-11-28T15:45:58Z20110146-6615http://repositorio.ufba.br/ri/handle/ri/16675v. 83, n. 12Texto completo: acesso restrito. p. 2066–2072The extraordinary genetic diversity and immune evasion of human immunodeficiency virus (HIV) pose significant challenges for vaccine development and antiretroviral therapy efficacy. The objective of this study was to characterize the molecular profile of HIV-1 epidemic in Salvador, Bahia, Brazil, determining the genetic subtypes and the presence of antiretroviral resistance mutations. HIV-1 pol DNA sequences from 57 individuals infected with HIV were obtained by PCR, followed by sequencing. The subtypes were determined by phylogenetic analyses and the intersubtype recombination was investigated by bootscanning. The pol subtypes were compared with gag and env subtypes. Antiretroviral susceptibility was evaluated through the Stanford HIV resistance Database. The subtypes frequencies were: 77.2% of subtype B, 1.8% of subtype F1, and 21.0% of BF recombinant forms. Two intergenic and three intragenic BF recombinant patterns were observed. Six (10.5%) viruses were related to CRF28/CRF29, two were related to CRF12 (3.5%), and one (1.8%) was CRF39. Fourteen (24.6%) strains carried one or more mutations associated with at least intermediate resistance: 24.6% had resistance to nucleoside reverse transcriptase inhibitors, 21.0% to non-nucleoside reverse transcriptase inhibitors, and 7% to protease inhibitors. The substitutions I54V (7.0%), M184V (14.0%), and K103N (10.5%) were the most frequent within each class of drugs. The results show a high diversity of BF genotypes and a lower prevalence of major reverse transcriptase and protease drug resistance mutations in Salvador, compared with other regions of Brazil. These findings may contribute to improve treatment strategies of patients infected with HIV-1 from this Brazilian region.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-18T14:16:33Z No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-28T15:45:58Z (GMT) No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5)Made available in DSpace on 2014-11-28T15:45:58Z (GMT). No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1002/jmv.22170reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1CRFResistanceDetection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast BrazilJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALBernardo Galvao Castro.pdfBernardo Galvao Castro.pdfapplication/pdf175093https://repositorio.ufba.br/bitstream/ri/16675/1/Bernardo%20Galvao%20Castro.pdf7161dacf3400a63091b7578201e1e0d9MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16675/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTBernardo Galvao Castro.pdf.txtBernardo Galvao Castro.pdf.txtExtracted texttext/plain27585https://repositorio.ufba.br/bitstream/ri/16675/3/Bernardo%20Galvao%20Castro.pdf.txta362b7ee01812b4ddedfd0f1fee0af6aMD53ri/166752022-07-05 14:02:57.907oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:57Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
spellingShingle Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
Santos, Luciane Amorim
HIV-1
CRF
Resistance
title_short Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
title_full Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
title_fullStr Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
title_full_unstemmed Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
title_sort Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
author Santos, Luciane Amorim
author_facet Santos, Luciane Amorim
Cunha, Joana Paixao Monteiro
Araujo, Adriano Fernando
Brites, Carlos
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author_role author
author2 Cunha, Joana Paixao Monteiro
Araujo, Adriano Fernando
Brites, Carlos
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Luciane Amorim
Cunha, Joana Paixao Monteiro
Araujo, Adriano Fernando
Brites, Carlos
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
Santos, Luciane Amorim
Cunha, Joana Paixao Monteiro
Araujo, Adriano Fernando
Brites, Carlos
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
dc.subject.por.fl_str_mv HIV-1
CRF
Resistance
topic HIV-1
CRF
Resistance
description Texto completo: acesso restrito. p. 2066–2072
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-11-28T15:45:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16675
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 83, n. 12
identifier_str_mv 0146-6615
v. 83, n. 12
url http://repositorio.ufba.br/ri/handle/ri/16675
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1002/jmv.22170
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
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