Abordagem bayesiana da sensitividade de modelos para o coeficiente de endogamia

• Autor(a) principal: Reis, Ricardo Luis dos
• Data de Publicação: 2009
• Outros Autores: Muniz, Joel Augusto, Silva, Fabyano Fonseca e, Sáfadi, Thelma, Aquino, Luiz Henrique de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFLA
• Texto Completo: http://repositorio.ufla.br/jspui/handle/1/38189
• topic: Fator de Bayes; Desequilíbrio de Hardy-Weinberg; Simulação de dados; Bayes factor; Hardy-Weinberg disequilibrium; Data simulation

The aim of this research is to perform a Bayesian characterization of the Hardy-Weinberg disequilibrium through the Bayes factor. The methodology is tested by using both simulation study and actual data. It was used the following priors for the Bayesian models: Dirichlet (model 1), beta - step uniform function (model 2), uniform - step uniform function (model 3) and independent uniforms for the inbreeding coefficients and allele frequencies (model 4). Metropolis-Hasting algorithms were implemented using the software R to simulate multiple draws from the posterior distribution. Convergence of the Metropolis-Hasting algorithms was assessed by many methods available at R package BOA. Results showed that the model 1 presents the best performance for both simulation study and actual data. The results also showed that the Bayesian approach provides models that are useful for the analysis of the Hardy-Weinberg disequilibrium and inbreeding coefficient.