Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate
Main Author: | |
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Publication Date: | 2011 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017 |
Summary: | Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2 - vincristine sulphate (4mg/m²), G3 - physiologic solution, G4 - physiologic solution, G5- vincristine sulphate (4mg/m²), and G6 - vincristine sulphate (4mg/m²). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3 - nandrolone decanoate (1.8mg/kg-1), G4 - nandrolone decanoate (10mg/kg-1), G5 - nandrolone decanoate (1.8mg/kg-1), and G6 - nandrolone decanoate (10mg/kg-1). Lipid peroxidation increased with the isolated use of vincristine and nandrolone decanoate, and with vincristine associated to the highest dose of the ester as well. These results suggest that vincristine sulphate and nandrolone decanoate increase free radical production. Therapeutic dose of nandrolone decanoate when associated with vincristine sulphate proved to be beneficial, as it was able to protect the organism from damaging processes involved in free radical production |
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Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoateratanabolic androgenic steroidchemotherapeuticfree radicalsbrainblood serumBrain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2 - vincristine sulphate (4mg/m²), G3 - physiologic solution, G4 - physiologic solution, G5- vincristine sulphate (4mg/m²), and G6 - vincristine sulphate (4mg/m²). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3 - nandrolone decanoate (1.8mg/kg-1), G4 - nandrolone decanoate (10mg/kg-1), G5 - nandrolone decanoate (1.8mg/kg-1), and G6 - nandrolone decanoate (10mg/kg-1). Lipid peroxidation increased with the isolated use of vincristine and nandrolone decanoate, and with vincristine associated to the highest dose of the ester as well. These results suggest that vincristine sulphate and nandrolone decanoate increase free radical production. Therapeutic dose of nandrolone decanoate when associated with vincristine sulphate proved to be beneficial, as it was able to protect the organism from damaging processes involved in free radical productionUniversidade Federal de Minas Gerais, Escola de Veterinária2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.63 n.1 2011reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352011000100017info:eu-repo/semantics/openAccessMartins,D.BLopes,S.T.AMazzanti,C.MSpanevello,RSchmatz,RCorrêa,MStefanello,NSchetinger,M.RMorsch,VVeiga,A.P.Meng2011-04-08T00:00:00Zoai:scielo:S0102-09352011000100017Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2011-04-08T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
title |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
spellingShingle |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate Martins,D.B rat anabolic androgenic steroid chemotherapeutic free radicals brain blood serum |
title_short |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
title_full |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
title_fullStr |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
title_full_unstemmed |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
title_sort |
Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate |
author |
Martins,D.B |
author_facet |
Martins,D.B Lopes,S.T.A Mazzanti,C.M Spanevello,R Schmatz,R Corrêa,M Stefanello,N Schetinger,M.R Morsch,V Veiga,A.P.M |
author_role |
author |
author2 |
Lopes,S.T.A Mazzanti,C.M Spanevello,R Schmatz,R Corrêa,M Stefanello,N Schetinger,M.R Morsch,V Veiga,A.P.M |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Martins,D.B Lopes,S.T.A Mazzanti,C.M Spanevello,R Schmatz,R Corrêa,M Stefanello,N Schetinger,M.R Morsch,V Veiga,A.P.M |
dc.subject.por.fl_str_mv |
rat anabolic androgenic steroid chemotherapeutic free radicals brain blood serum |
topic |
rat anabolic androgenic steroid chemotherapeutic free radicals brain blood serum |
description |
Brain and serum lipid peroxidation was studied in rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were distributed into six groups (n=5). The treatments were applied once a week for two weeks. Sample collection was performed in the third week. Treatments during the first week were: G1 (control) - physiologic solution, G2 - vincristine sulphate (4mg/m²), G3 - physiologic solution, G4 - physiologic solution, G5- vincristine sulphate (4mg/m²), and G6 - vincristine sulphate (4mg/m²). In the second week, they were: G1 (control) - physiologic solution, G2- physiologic solution, G3 - nandrolone decanoate (1.8mg/kg-1), G4 - nandrolone decanoate (10mg/kg-1), G5 - nandrolone decanoate (1.8mg/kg-1), and G6 - nandrolone decanoate (10mg/kg-1). Lipid peroxidation increased with the isolated use of vincristine and nandrolone decanoate, and with vincristine associated to the highest dose of the ester as well. These results suggest that vincristine sulphate and nandrolone decanoate increase free radical production. Therapeutic dose of nandrolone decanoate when associated with vincristine sulphate proved to be beneficial, as it was able to protect the organism from damaging processes involved in free radical production |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000100017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-09352011000100017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais, Escola de Veterinária |
dc.source.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.63 n.1 2011 reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
collection |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) |
repository.name.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br |
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1750220884115718144 |