Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/39984 |
Resumo: | The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas. |
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2022-03-11T15:19:56Z2022-03-11T15:19:56Z201971114315010.1590/1678-4162-1025916784162http://hdl.handle.net/1843/39984The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas.O objetivo deste estudo foi relacionar a concentração sérica de IL-6, IGF-1, leptina e estrogênio em cadelas não castradas com ou sem excesso de peso e carcinomas mamários em estágio inicial. Quarenta e três cadelas foram divididas em quatro grupos, dois grupos sem carcinoma mamário com e sem sobrepeso e dois grupos com carcinoma mamário com e sem sobrepeso. Cadelas com excesso de peso, com ou sem carcinoma mamário, foram estatisticamente diferentes das cadelas quanto ao peso ideal, em relação ao ECC, IMCC e percentuais de gordura corporal (P< 0,0001). Houve correlação positiva entre ECC e IMCC (P<0,0001), ECC e %GC (P<0,0001) e IMCC e %GC (P<0,0001). Uma correlação positiva foi encontrada entre leptina sérica e IL-6 (P= 0,0451) e leptina e IGF-1 (P= 0,05). Foi encontrada correlação positiva (P= 0,0053) entre CEC e leptina na análise dos métodos de avaliação corporal e concentrações séricas, e correlação negativa entre CEC e IL-6 (P= 0,0435). Entre o percentual de gordura e a concentração de leptina, houve correlação positiva (P= 0,0016), assim como encontrada entre o IMCC e a leptina (P= 0,0209). Neste estudo, não foi observada associação entre o excesso de peso e a presença de carcinomas mamários em estágio inicial.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE PATOLOGIAArquivo brasileiro de medicina veterinária e zootecniaCadelaObesidadeSobrepesoCarcinomaGlândula mamáriaEstadioSerum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinomaAvaliação sérica de leptina, il-6, igf-1 e estrogênio em cadelas obesas com estágios iniciais de carcinoma mamárioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/abmvz/a/5bPYL4wK7KVGH8rM7V9qc8v/?lang=enS. V. TeixeiraIstéfani Luciene Dayse da SilvaF. C. NunesCecília Bonolo de CamposM. R. OliveiraGleidice Eunice LavalleGeovanni Dantas Cassaliapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/39984/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINAL2019_Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with.pdf2019_Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with.pdfapplication/pdf354771https://repositorio.ufmg.br/bitstream/1843/39984/2/2019_Serum%20evaluation%20of%20leptin%2c%20IL-6%2c%20IGF-1%20and%20estrogen%20in%20obese%20bitches%20with.pdfe259a0a23df7fb91a8f888cad06d21e2MD521843/399842022-03-11 12:19:56.391oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-11T15:19:56Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
dc.title.alternative.pt_BR.fl_str_mv |
Avaliação sérica de leptina, il-6, igf-1 e estrogênio em cadelas obesas com estágios iniciais de carcinoma mamário |
title |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
spellingShingle |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma S. V. Teixeira Cadela Obesidade Sobrepeso Carcinoma Glândula mamária Estadio |
title_short |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
title_full |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
title_fullStr |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
title_full_unstemmed |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
title_sort |
Serum evaluation of leptin, il-6, igf-1 and estrogen in obese bitches with early stages of mammary carcinoma |
author |
S. V. Teixeira |
author_facet |
S. V. Teixeira Istéfani Luciene Dayse da Silva F. C. Nunes Cecília Bonolo de Campos M. R. Oliveira Gleidice Eunice Lavalle Geovanni Dantas Cassali |
author_role |
author |
author2 |
Istéfani Luciene Dayse da Silva F. C. Nunes Cecília Bonolo de Campos M. R. Oliveira Gleidice Eunice Lavalle Geovanni Dantas Cassali |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
S. V. Teixeira Istéfani Luciene Dayse da Silva F. C. Nunes Cecília Bonolo de Campos M. R. Oliveira Gleidice Eunice Lavalle Geovanni Dantas Cassali |
dc.subject.other.pt_BR.fl_str_mv |
Cadela Obesidade Sobrepeso Carcinoma Glândula mamária Estadio |
topic |
Cadela Obesidade Sobrepeso Carcinoma Glândula mamária Estadio |
description |
The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2022-03-11T15:19:56Z |
dc.date.available.fl_str_mv |
2022-03-11T15:19:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/39984 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/1678-4162-10259 |
dc.identifier.issn.pt_BR.fl_str_mv |
16784162 |
identifier_str_mv |
10.1590/1678-4162-10259 16784162 |
url |
http://hdl.handle.net/1843/39984 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Arquivo brasileiro de medicina veterinária e zootecnia |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE PATOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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