The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice.
Autor(a) principal: | |
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Data de Publicação: | 1990 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/4783 https://doi.org/10.1016/0300-9629(90)90178-U |
Resumo: | l. CFW mice were fed either on control diet or on iron-deficient diet. 2. After 5 months the mice were infected with CL, Y or YuYu strain of Trypanosoma cruzi. 3. On the fifth day after the infection, the mice on control diet were divided in three groups: one group remained as controls, two groups were injected either with desferrioxamine or iron-dextran. 4. The severity of the disease was evaluated by parasitemia and mortality. 5. The experimental groups were compared with the infected group fed on the control diet. 6. In mice fed on the iron-deficient diet, the disease was more severe for CL strain and less severe for Y and YuYu strains. 7. Treatment with desferrioxamine produced a less severe disease with YuYu strain and no difference with the other strains. 8. On treatment with iron-dextran, the disease became more severe with Y and CL strains; no effect was observed with YuYu strain. 9. These findings may be due to intraspecific differences among the strains. |
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Pedrosa, Maria LúciaSilva, Marcelo EustáquioSilva, Marcio EustáquioSilva, Marcílio Eustáquio de CastroNicoli, Jacques RobertVieira, Enio Carlos2015-03-25T16:09:01Z2015-03-25T16:09:01Z1990PEDROSA, M. L. et al. The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. Comparative Biochemistry And Physiology A, Gran Bretanha, v. 97, n.2, p. 235-243, 1990. Disponível em: <http://www.sciencedirect.com/science/article/pii/030096299090178U>. Acesso em: 20 fev. 2015.1095-6433http://www.repositorio.ufop.br/handle/123456789/4783https://doi.org/10.1016/0300-9629(90)90178-Ul. CFW mice were fed either on control diet or on iron-deficient diet. 2. After 5 months the mice were infected with CL, Y or YuYu strain of Trypanosoma cruzi. 3. On the fifth day after the infection, the mice on control diet were divided in three groups: one group remained as controls, two groups were injected either with desferrioxamine or iron-dextran. 4. The severity of the disease was evaluated by parasitemia and mortality. 5. The experimental groups were compared with the infected group fed on the control diet. 6. In mice fed on the iron-deficient diet, the disease was more severe for CL strain and less severe for Y and YuYu strains. 7. Treatment with desferrioxamine produced a less severe disease with YuYu strain and no difference with the other strains. 8. On treatment with iron-dextran, the disease became more severe with Y and CL strains; no effect was observed with YuYu strain. 9. These findings may be due to intraspecific differences among the strains.The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577130333774.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/4783/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_EffectIronDeficiency.pdfARTIGO_EffectIronDeficiency.pdfapplication/pdf752674http://www.repositorio.ufop.br/bitstream/123456789/4783/1/ARTIGO_EffectIronDeficiency.pdffa512a3e54dbc73c52c99cbcedfbe1edMD51123456789/47832019-06-28 13:44:53.604oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-06-28T17:44:53Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
title |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
spellingShingle |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. Pedrosa, Maria Lúcia |
title_short |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
title_full |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
title_fullStr |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
title_full_unstemmed |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
title_sort |
The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. |
author |
Pedrosa, Maria Lúcia |
author_facet |
Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio Silva, Marcio Eustáquio Silva, Marcílio Eustáquio de Castro Nicoli, Jacques Robert Vieira, Enio Carlos |
author_role |
author |
author2 |
Silva, Marcelo Eustáquio Silva, Marcio Eustáquio Silva, Marcílio Eustáquio de Castro Nicoli, Jacques Robert Vieira, Enio Carlos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio Silva, Marcio Eustáquio Silva, Marcílio Eustáquio de Castro Nicoli, Jacques Robert Vieira, Enio Carlos |
description |
l. CFW mice were fed either on control diet or on iron-deficient diet. 2. After 5 months the mice were infected with CL, Y or YuYu strain of Trypanosoma cruzi. 3. On the fifth day after the infection, the mice on control diet were divided in three groups: one group remained as controls, two groups were injected either with desferrioxamine or iron-dextran. 4. The severity of the disease was evaluated by parasitemia and mortality. 5. The experimental groups were compared with the infected group fed on the control diet. 6. In mice fed on the iron-deficient diet, the disease was more severe for CL strain and less severe for Y and YuYu strains. 7. Treatment with desferrioxamine produced a less severe disease with YuYu strain and no difference with the other strains. 8. On treatment with iron-dextran, the disease became more severe with Y and CL strains; no effect was observed with YuYu strain. 9. These findings may be due to intraspecific differences among the strains. |
publishDate |
1990 |
dc.date.issued.fl_str_mv |
1990 |
dc.date.accessioned.fl_str_mv |
2015-03-25T16:09:01Z |
dc.date.available.fl_str_mv |
2015-03-25T16:09:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEDROSA, M. L. et al. The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. Comparative Biochemistry And Physiology A, Gran Bretanha, v. 97, n.2, p. 235-243, 1990. Disponível em: <http://www.sciencedirect.com/science/article/pii/030096299090178U>. Acesso em: 20 fev. 2015. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/4783 |
dc.identifier.issn.none.fl_str_mv |
1095-6433 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/0300-9629(90)90178-U |
identifier_str_mv |
PEDROSA, M. L. et al. The effect of iron deficiency and iron overload on the evolution of chagas disease produced by three strains of trypanosoma cruzi in CFW mice. Comparative Biochemistry And Physiology A, Gran Bretanha, v. 97, n.2, p. 235-243, 1990. Disponível em: <http://www.sciencedirect.com/science/article/pii/030096299090178U>. Acesso em: 20 fev. 2015. 1095-6433 |
url |
http://www.repositorio.ufop.br/handle/123456789/4783 https://doi.org/10.1016/0300-9629(90)90178-U |
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eng |
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