Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/5180 |
Resumo: | Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies. |
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2014-06-30T12:54:33Z2014-06-30T12:54:33Z2000-11BURBANO, R.R. et al. Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 33, n. 11, p. 1325-1328, nov. 2000. Disponível em: <http://www.scielo.br/pdf/bjmbr/v33n11/3793m.pdf>. Acesso em: 24 fev. 2014. <http://dx.doi.org/10.1590/S0100-879X2000001100010>.1414-431Xhttp://repositorio.ufpa.br/jspui/handle/2011/5180Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies.engTP53Neoplasias da mamaCâncer de mamaHistória familiarMutaçãoGene TP53Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRODRÍGUEZ BURBANO, Rommel MarioMEDEIROS, Arnaldo Correia deMELLO, Adriano Azevedo deLEMOS, José Alexandre Rodrigues deBAHIA, Marcelo de OliveiraCASARTELLI, Cacildainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_InvestigationSingleStrand.pdfArtigo_InvestigationSingleStrand.pdfapplication/pdf141766http://repositorio.ufpa.br/oai/bitstream/2011/5180/1/Artigo_InvestigationSingleStrand.pdfa53d7f58b4ba6cb8ad58015334a939f0MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/5180/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-821936http://repositorio.ufpa.br/oai/bitstream/2011/5180/3/license_text9833653f73f7853880c94a6fead477b1MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823148http://repositorio.ufpa.br/oai/bitstream/2011/5180/4/license_rdf9da0b6dfac957114c6a7714714b86306MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81775http://repositorio.ufpa.br/oai/bitstream/2011/5180/5/license.txta930293e49ae6e6b5c49a341d4a36286MD55TEXTArtigo_InvestigationSingleStrand.pdf.txtArtigo_InvestigationSingleStrand.pdf.txtExtracted texttext/plain13196http://repositorio.ufpa.br/oai/bitstream/2011/5180/6/Artigo_InvestigationSingleStrand.pdf.txtabf8c425fbfc0817efda9f7132bcac64MD562011/51802017-10-16 12:20:42.265oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232017-10-16T15:20:42Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.pt_BR.fl_str_mv |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
title |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
spellingShingle |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer RODRÍGUEZ BURBANO, Rommel Mario TP53 Neoplasias da mama Câncer de mama História familiar Mutação Gene TP53 |
title_short |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
title_full |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
title_fullStr |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
title_full_unstemmed |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
title_sort |
Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer |
author |
RODRÍGUEZ BURBANO, Rommel Mario |
author_facet |
RODRÍGUEZ BURBANO, Rommel Mario MEDEIROS, Arnaldo Correia de MELLO, Adriano Azevedo de LEMOS, José Alexandre Rodrigues de BAHIA, Marcelo de Oliveira CASARTELLI, Cacilda |
author_role |
author |
author2 |
MEDEIROS, Arnaldo Correia de MELLO, Adriano Azevedo de LEMOS, José Alexandre Rodrigues de BAHIA, Marcelo de Oliveira CASARTELLI, Cacilda |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
RODRÍGUEZ BURBANO, Rommel Mario MEDEIROS, Arnaldo Correia de MELLO, Adriano Azevedo de LEMOS, José Alexandre Rodrigues de BAHIA, Marcelo de Oliveira CASARTELLI, Cacilda |
dc.subject.por.fl_str_mv |
TP53 Neoplasias da mama Câncer de mama História familiar Mutação Gene TP53 |
topic |
TP53 Neoplasias da mama Câncer de mama História familiar Mutação Gene TP53 |
description |
Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-11 |
dc.date.accessioned.fl_str_mv |
2014-06-30T12:54:33Z |
dc.date.available.fl_str_mv |
2014-06-30T12:54:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BURBANO, R.R. et al. Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 33, n. 11, p. 1325-1328, nov. 2000. Disponível em: <http://www.scielo.br/pdf/bjmbr/v33n11/3793m.pdf>. Acesso em: 24 fev. 2014. <http://dx.doi.org/10.1590/S0100-879X2000001100010>. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/5180 |
dc.identifier.issn.none.fl_str_mv |
1414-431X |
identifier_str_mv |
BURBANO, R.R. et al. Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 33, n. 11, p. 1325-1328, nov. 2000. Disponível em: <http://www.scielo.br/pdf/bjmbr/v33n11/3793m.pdf>. Acesso em: 24 fev. 2014. <http://dx.doi.org/10.1590/S0100-879X2000001100010>. 1414-431X |
url |
http://repositorio.ufpa.br/jspui/handle/2011/5180 |
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eng |
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eng |
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openAccess |
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