Preliminar analysis of patients with streptococcal tonsillopharyngitis: a comparison of amoxicillin twice a day with amoxicillin three times a day

• Main Author: Rotta Pereira, M. Beatriz
• Publication Date: 2022
• Other Authors: R. Pereira, Manuel, Aguillar, Antonio, Huicho, Luis, Trujillo, Hugo, Cahali, Samir
• Format: Article
• Language: por
• Source: Clinical and Biomedical Research
• Download full: https://seer.ufrgs.br/index.php/hcpa/article/view/125221
• topic: Faringotonsilite estreptocócica; amoxicilina; Streptococus pyogenes; Streptococcal tonsillopharyngitis; amoxicillin; Streptococus pyogenes

OBJECTIVES: To compare the efficacy and tolerance of two posologic amoxicillin schemes in children with tonsillopharyngitis: 45 mg/kg/day in two doses (bid) and 40 mg/kg/day in three doses (tid). MATERIALS AND METHODS: We conducted a multicentric, randomized, single-blinded study, comparing two parallel groups. One hundred and seventy-one ambulatrial patients with ages between 2 and 12 years presenting acute bacterial tonsillopharyngitis were admitted in this study. Patients were evaluated in the selection visit, within threedays of treatment, at the end of treatment and within 28 days after entering the study in order to verify clinical response, possible adverse effects, bacteriological response, and tolerabilty of the medication.RESULTS: The preliminary analysis of the 171 patients, 86 randomized to “treatment A” group and 85 to “treatment B”, indicates that in the final visit, 83 “treatment A” patients (96.5%) and 82 patients (96.5%) ”treatament B” patients presented clinical criteria of cure.CONCLUSION: The present data suggest that the therapeutic scheme of amoxicillin administrated twice daily (bd) is as efficient as the three times per day scheme (tid) for the treatament of these patients, with the possible advantage of a greater adherence of patients to the treatment.